Extracellular vesicle-derived miR-320a targets ZC3H12B to inhibit tumorigenesis, invasion, and angiogenesis in ovarian cancer

Abstract Extracellular vesicles (EVs) play crucial roles in intercellular communication. miRNAs derived from EVs emerge as promising diagnostic indicators and therapeutic targets in a variety of malignancies. Tremendous studies have revealed the function of miRNAs derived from EVs in tumorigenesis,...

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Autores principales:	Yan Huang, Midie Xu, Chuyu Jing, Xiaohua Wu, Xiaojun Chen, Wei Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Springer 2021
Materias:	Extracellular vesicles miR-320a ZC3H12B Ovarian cancer Tumorigenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/53d18ae368ca4a4bb492d57c4605339b
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spelling	oai:doaj.org-article:53d18ae368ca4a4bb492d57c4605339b2021-11-21T12:42:49ZExtracellular vesicle-derived miR-320a targets ZC3H12B to inhibit tumorigenesis, invasion, and angiogenesis in ovarian cancer10.1007/s12672-021-00437-22730-6011https://doaj.org/article/53d18ae368ca4a4bb492d57c4605339b2021-11-01T00:00:00Zhttps://doi.org/10.1007/s12672-021-00437-2https://doaj.org/toc/2730-6011Abstract Extracellular vesicles (EVs) play crucial roles in intercellular communication. miRNAs derived from EVs emerge as promising diagnostic indicators and therapeutic targets in a variety of malignancies. Tremendous studies have revealed the function of miRNAs derived from EVs in tumorigenesis, metastasis and other aspects. The mechanism of action of EV-derived miRNAs, however, in ovarian cancer remains largely unknown. In this study, EVs were enriched from the ovarian cancer cell lines. EVs as a whole could promote cell proliferation, invasion and new vasculature formation. However, the down-regulated EV-derived miR-320a was demonstrated to potentially suppress tumorigenesis, metastasis and angiogenesis. Moreover, EV-derived miR-320a has been proved to directly regulate a previously unknown target, ZC3H12B. An unreported role of ZC3H12B in promoting ovarian cancer cell proliferation has been elucidated and miR-320a could mediate the expression of ZC3H12B, thereby inhibiting the downstream response. As for the practical clinic values, lower expression of EV-derived miR-320a correlates with shorter survival period, indicating that EV-derived miR-320a may also serve as a prognostic biomarker in ovarian cancer. This research provides new insight into the molecular mechanism of EV-derived miR-320a in ovarian cancer and may provide new therapeutic and prognostic strategies for ovarian cancer treatment.Yan HuangMidie XuChuyu JingXiaohua WuXiaojun ChenWei ZhangSpringerarticleExtracellular vesiclesmiR-320aZC3H12BOvarian cancerTumorigenesisNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENDiscover Oncology, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Extracellular vesicles miR-320a ZC3H12B Ovarian cancer Tumorigenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Extracellular vesicles miR-320a ZC3H12B Ovarian cancer Tumorigenesis Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yan Huang Midie Xu Chuyu Jing Xiaohua Wu Xiaojun Chen Wei Zhang Extracellular vesicle-derived miR-320a targets ZC3H12B to inhibit tumorigenesis, invasion, and angiogenesis in ovarian cancer
description	Abstract Extracellular vesicles (EVs) play crucial roles in intercellular communication. miRNAs derived from EVs emerge as promising diagnostic indicators and therapeutic targets in a variety of malignancies. Tremendous studies have revealed the function of miRNAs derived from EVs in tumorigenesis, metastasis and other aspects. The mechanism of action of EV-derived miRNAs, however, in ovarian cancer remains largely unknown. In this study, EVs were enriched from the ovarian cancer cell lines. EVs as a whole could promote cell proliferation, invasion and new vasculature formation. However, the down-regulated EV-derived miR-320a was demonstrated to potentially suppress tumorigenesis, metastasis and angiogenesis. Moreover, EV-derived miR-320a has been proved to directly regulate a previously unknown target, ZC3H12B. An unreported role of ZC3H12B in promoting ovarian cancer cell proliferation has been elucidated and miR-320a could mediate the expression of ZC3H12B, thereby inhibiting the downstream response. As for the practical clinic values, lower expression of EV-derived miR-320a correlates with shorter survival period, indicating that EV-derived miR-320a may also serve as a prognostic biomarker in ovarian cancer. This research provides new insight into the molecular mechanism of EV-derived miR-320a in ovarian cancer and may provide new therapeutic and prognostic strategies for ovarian cancer treatment.
format	article
author	Yan Huang Midie Xu Chuyu Jing Xiaohua Wu Xiaojun Chen Wei Zhang
author_facet	Yan Huang Midie Xu Chuyu Jing Xiaohua Wu Xiaojun Chen Wei Zhang
author_sort	Yan Huang
title	Extracellular vesicle-derived miR-320a targets ZC3H12B to inhibit tumorigenesis, invasion, and angiogenesis in ovarian cancer
title_short	Extracellular vesicle-derived miR-320a targets ZC3H12B to inhibit tumorigenesis, invasion, and angiogenesis in ovarian cancer
title_full	Extracellular vesicle-derived miR-320a targets ZC3H12B to inhibit tumorigenesis, invasion, and angiogenesis in ovarian cancer
title_fullStr	Extracellular vesicle-derived miR-320a targets ZC3H12B to inhibit tumorigenesis, invasion, and angiogenesis in ovarian cancer
title_full_unstemmed	Extracellular vesicle-derived miR-320a targets ZC3H12B to inhibit tumorigenesis, invasion, and angiogenesis in ovarian cancer
title_sort	extracellular vesicle-derived mir-320a targets zc3h12b to inhibit tumorigenesis, invasion, and angiogenesis in ovarian cancer
publisher	Springer
publishDate	2021
url	https://doaj.org/article/53d18ae368ca4a4bb492d57c4605339b
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Extracellular vesicle-derived miR-320a targets ZC3H12B to inhibit tumorigenesis, invasion, and angiogenesis in ovarian cancer

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