Short H2A histone variants are expressed in cancer

Short H2A histone variants are expressed in cancer

Short H2A variants are testis-specific histones that destabilize nucleosomes during spermatogenesis. In this study, the authors show that these variants are expressed in an array of different cancers and identify splicing changes associated with nucleosome instability in these malignancies.

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Auteurs principaux: Guo-Liang Chew, Marie Bleakley, Robert K. Bradley, Harmit S. Malik, Steven Henikoff, Antoine Molaro, Jay Sarthy
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Science
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Accès en ligne:https://doaj.org/article/53d7c5a963ab49e9ab627725b16041d3
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id oai:doaj.org-article:53d7c5a963ab49e9ab627725b16041d3
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spelling oai:doaj.org-article:53d7c5a963ab49e9ab627725b16041d32021-12-02T10:49:08ZShort H2A histone variants are expressed in cancer10.1038/s41467-020-20707-x2041-1723https://doaj.org/article/53d7c5a963ab49e9ab627725b16041d32021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20707-xhttps://doaj.org/toc/2041-1723Short H2A variants are testis-specific histones that destabilize nucleosomes during spermatogenesis. In this study, the authors show that these variants are expressed in an array of different cancers and identify splicing changes associated with nucleosome instability in these malignancies.Guo-Liang ChewMarie BleakleyRobert K. BradleyHarmit S. MalikSteven HenikoffAntoine MolaroJay SarthyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Guo-Liang Chew
Marie Bleakley
Robert K. Bradley
Harmit S. Malik
Steven Henikoff
Antoine Molaro
Jay Sarthy
Short H2A histone variants are expressed in cancer
description Short H2A variants are testis-specific histones that destabilize nucleosomes during spermatogenesis. In this study, the authors show that these variants are expressed in an array of different cancers and identify splicing changes associated with nucleosome instability in these malignancies.
format article
author Guo-Liang Chew
Marie Bleakley
Robert K. Bradley
Harmit S. Malik
Steven Henikoff
Antoine Molaro
Jay Sarthy
author_facet Guo-Liang Chew
Marie Bleakley
Robert K. Bradley
Harmit S. Malik
Steven Henikoff
Antoine Molaro
Jay Sarthy
author_sort Guo-Liang Chew
title Short H2A histone variants are expressed in cancer
title_short Short H2A histone variants are expressed in cancer
title_full Short H2A histone variants are expressed in cancer
title_fullStr Short H2A histone variants are expressed in cancer
title_full_unstemmed Short H2A histone variants are expressed in cancer
title_sort short h2a histone variants are expressed in cancer
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/53d7c5a963ab49e9ab627725b16041d3
work_keys_str_mv AT guoliangchew shorth2ahistonevariantsareexpressedincancer
AT mariebleakley shorth2ahistonevariantsareexpressedincancer
AT robertkbradley shorth2ahistonevariantsareexpressedincancer
AT harmitsmalik shorth2ahistonevariantsareexpressedincancer
AT stevenhenikoff shorth2ahistonevariantsareexpressedincancer
AT antoinemolaro shorth2ahistonevariantsareexpressedincancer
AT jaysarthy shorth2ahistonevariantsareexpressedincancer
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