Short H2A histone variants are expressed in cancer

Short H2A variants are testis-specific histones that destabilize nucleosomes during spermatogenesis. In this study, the authors show that these variants are expressed in an array of different cancers and identify splicing changes associated with nucleosome instability in these malignancies.

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Autores principales:	Guo-Liang Chew, Marie Bleakley, Robert K. Bradley, Harmit S. Malik, Steven Henikoff, Antoine Molaro, Jay Sarthy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53d7c5a963ab49e9ab627725b16041d3
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spelling	oai:doaj.org-article:53d7c5a963ab49e9ab627725b16041d32021-12-02T10:49:08ZShort H2A histone variants are expressed in cancer10.1038/s41467-020-20707-x2041-1723https://doaj.org/article/53d7c5a963ab49e9ab627725b16041d32021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20707-xhttps://doaj.org/toc/2041-1723Short H2A variants are testis-specific histones that destabilize nucleosomes during spermatogenesis. In this study, the authors show that these variants are expressed in an array of different cancers and identify splicing changes associated with nucleosome instability in these malignancies.Guo-Liang ChewMarie BleakleyRobert K. BradleyHarmit S. MalikSteven HenikoffAntoine MolaroJay SarthyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guo-Liang Chew Marie Bleakley Robert K. Bradley Harmit S. Malik Steven Henikoff Antoine Molaro Jay Sarthy Short H2A histone variants are expressed in cancer
description	Short H2A variants are testis-specific histones that destabilize nucleosomes during spermatogenesis. In this study, the authors show that these variants are expressed in an array of different cancers and identify splicing changes associated with nucleosome instability in these malignancies.
format	article
author	Guo-Liang Chew Marie Bleakley Robert K. Bradley Harmit S. Malik Steven Henikoff Antoine Molaro Jay Sarthy
author_facet	Guo-Liang Chew Marie Bleakley Robert K. Bradley Harmit S. Malik Steven Henikoff Antoine Molaro Jay Sarthy
author_sort	Guo-Liang Chew
title	Short H2A histone variants are expressed in cancer
title_short	Short H2A histone variants are expressed in cancer
title_full	Short H2A histone variants are expressed in cancer
title_fullStr	Short H2A histone variants are expressed in cancer
title_full_unstemmed	Short H2A histone variants are expressed in cancer
title_sort	short h2a histone variants are expressed in cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/53d7c5a963ab49e9ab627725b16041d3
work_keys_str_mv	AT guoliangchew shorth2ahistonevariantsareexpressedincancer AT mariebleakley shorth2ahistonevariantsareexpressedincancer AT robertkbradley shorth2ahistonevariantsareexpressedincancer AT harmitsmalik shorth2ahistonevariantsareexpressedincancer AT stevenhenikoff shorth2ahistonevariantsareexpressedincancer AT antoinemolaro shorth2ahistonevariantsareexpressedincancer AT jaysarthy shorth2ahistonevariantsareexpressedincancer
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Short H2A histone variants are expressed in cancer

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