Short H2A histone variants are expressed in cancer

Short H2A variants are testis-specific histones that destabilize nucleosomes during spermatogenesis. In this study, the authors show that these variants are expressed in an array of different cancers and identify splicing changes associated with nucleosome instability in these malignancies.

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Autores principales: Guo-Liang Chew, Marie Bleakley, Robert K. Bradley, Harmit S. Malik, Steven Henikoff, Antoine Molaro, Jay Sarthy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/53d7c5a963ab49e9ab627725b16041d3
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