Increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study

Abstract Major depressive disorder (MDD) in the elderly is a risk factor for dementia, but the precise biological basis remains unknown, hampering the search for novel biomarkers and treatments. In this study, we performed metabolomics analysis of cerebrospinal fluid (CSF) from cognitively intact el...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kenji Hashimoto, Tamaki Ishima, Yasunori Sato, Davide Bruno, Jay Nierenberg, Charles R. Marmar, Henrik Zetterberg, Kaj Blennow, Nunzio Pomara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/53d83cccda604487839d56a1663021fc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:53d83cccda604487839d56a1663021fc
record_format	dspace
spelling	oai:doaj.org-article:53d83cccda604487839d56a1663021fc2021-12-02T12:32:12ZIncreased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study10.1038/s41598-017-03836-02045-2322https://doaj.org/article/53d83cccda604487839d56a1663021fc2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03836-0https://doaj.org/toc/2045-2322Abstract Major depressive disorder (MDD) in the elderly is a risk factor for dementia, but the precise biological basis remains unknown, hampering the search for novel biomarkers and treatments. In this study, we performed metabolomics analysis of cerebrospinal fluid (CSF) from cognitively intact elderly patients (N = 28) with MDD and age- and gender-matched healthy controls (N = 18). The CSF levels of 177 substances were measured, while 288 substances were below the detection limit. Only ascorbic acid was significantly different, with higher levels in the MDD group at baseline. There were no correlations between CSF ascorbic acid levels and clinical variables in MDD patients at baseline. At the 3-year follow-up, there was no difference of CSF ascorbic acid levels between the two groups. There was a negative correlation between CSF ascorbic acid and CSF amyloid-β42 levels in all subjects. However, there were no correlations between ascorbic acid and other biomarkers (e.g., amyloid-β40, total and phosphorylated tau protein). This preliminary study suggests that abnormalities in the transport and/or release of ascorbic acid might play a role in the pathogenesis of late-life depression.Kenji HashimotoTamaki IshimaYasunori SatoDavide BrunoJay NierenbergCharles R. MarmarHenrik ZetterbergKaj BlennowNunzio PomaraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kenji Hashimoto Tamaki Ishima Yasunori Sato Davide Bruno Jay Nierenberg Charles R. Marmar Henrik Zetterberg Kaj Blennow Nunzio Pomara Increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study
description	Abstract Major depressive disorder (MDD) in the elderly is a risk factor for dementia, but the precise biological basis remains unknown, hampering the search for novel biomarkers and treatments. In this study, we performed metabolomics analysis of cerebrospinal fluid (CSF) from cognitively intact elderly patients (N = 28) with MDD and age- and gender-matched healthy controls (N = 18). The CSF levels of 177 substances were measured, while 288 substances were below the detection limit. Only ascorbic acid was significantly different, with higher levels in the MDD group at baseline. There were no correlations between CSF ascorbic acid levels and clinical variables in MDD patients at baseline. At the 3-year follow-up, there was no difference of CSF ascorbic acid levels between the two groups. There was a negative correlation between CSF ascorbic acid and CSF amyloid-β42 levels in all subjects. However, there were no correlations between ascorbic acid and other biomarkers (e.g., amyloid-β40, total and phosphorylated tau protein). This preliminary study suggests that abnormalities in the transport and/or release of ascorbic acid might play a role in the pathogenesis of late-life depression.
format	article
author	Kenji Hashimoto Tamaki Ishima Yasunori Sato Davide Bruno Jay Nierenberg Charles R. Marmar Henrik Zetterberg Kaj Blennow Nunzio Pomara
author_facet	Kenji Hashimoto Tamaki Ishima Yasunori Sato Davide Bruno Jay Nierenberg Charles R. Marmar Henrik Zetterberg Kaj Blennow Nunzio Pomara
author_sort	Kenji Hashimoto
title	Increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study
title_short	Increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study
title_full	Increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study
title_fullStr	Increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study
title_full_unstemmed	Increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study
title_sort	increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/53d83cccda604487839d56a1663021fc
work_keys_str_mv	AT kenjihashimoto increasedlevelsofascorbicacidinthecerebrospinalfluidofcognitivelyintactelderlypatientswithmajordepressionapreliminarystudy AT tamakiishima increasedlevelsofascorbicacidinthecerebrospinalfluidofcognitivelyintactelderlypatientswithmajordepressionapreliminarystudy AT yasunorisato increasedlevelsofascorbicacidinthecerebrospinalfluidofcognitivelyintactelderlypatientswithmajordepressionapreliminarystudy AT davidebruno increasedlevelsofascorbicacidinthecerebrospinalfluidofcognitivelyintactelderlypatientswithmajordepressionapreliminarystudy AT jaynierenberg increasedlevelsofascorbicacidinthecerebrospinalfluidofcognitivelyintactelderlypatientswithmajordepressionapreliminarystudy AT charlesrmarmar increasedlevelsofascorbicacidinthecerebrospinalfluidofcognitivelyintactelderlypatientswithmajordepressionapreliminarystudy AT henrikzetterberg increasedlevelsofascorbicacidinthecerebrospinalfluidofcognitivelyintactelderlypatientswithmajordepressionapreliminarystudy AT kajblennow increasedlevelsofascorbicacidinthecerebrospinalfluidofcognitivelyintactelderlypatientswithmajordepressionapreliminarystudy AT nunziopomara increasedlevelsofascorbicacidinthecerebrospinalfluidofcognitivelyintactelderlypatientswithmajordepressionapreliminarystudy
_version_	1718394155749605376

Increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study

Ejemplares similares