Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A

Yogesh Dwivedi, Ghanshyam N PandeyPsychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USAAbstract: Mood disorders are among the most prevalent and recurrent forms of psychiatric illnesses. In the last decade, there has bee...

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Autores principales:	Yogesh Dwivedi, Ghanshyam N Pandey
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/53d843867aab41bd9cda2eef77a2bfd7
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spelling	oai:doaj.org-article:53d843867aab41bd9cda2eef77a2bfd72021-12-02T02:57:03ZAdenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A1176-63281178-2021https://doaj.org/article/53d843867aab41bd9cda2eef77a2bfd72008-03-01T00:00:00Zhttp://www.dovepress.com/adenylyl-cyclase-cyclicamp-signaling-in-mood-disorders-role-of-the-cru-a1004https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Yogesh Dwivedi, Ghanshyam N PandeyPsychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USAAbstract: Mood disorders are among the most prevalent and recurrent forms of psychiatric illnesses. In the last decade, there has been increased understanding of the biological basis of mood disorders. In fact, novel mechanistic concepts of the neurobiology of unipolar and bipolar disorders are evolving based on recent pre-clinical and clinical studies, most of which now focus on the role of signal transduction mechanisms in these psychiatric illnesses. Particular investigative emphasis has been given to the role of phosphorylating enzymes, which are crucial in regulating gene expression and neuronal and synaptic plasticity. Among the most important phosphorylating enzyme is protein kinase A (PKA), a component of adenylyl cyclase&minus;cyclic adenosine monophosphate (AC&minus;cAMP) signaling system. In this review, we critically and comprehensively discuss the role of various components of AC&minus;cAMP signaling in mood disorders, with a special focus on PKA, because of the interesting observation that have been made about its involvement in unipolar and bipolar disorders. We also discuss the functional significance of the findings regarding PKA by discussing the role of important PKA substrates, namely, Rap-1, cyclicAMP-response element binding protein, and brain-derived neurotrophic factor. These studies suggest the interesting possibility that PKA and related signaling molecules may serve as important neurobiological factors in mood disorders and may be relevant in target-specific therapeutic interventions for these disorders.Keywords: protein kinase A, bipolar disorder, unipolar depression, CREB, BDNF, Rap-1 Yogesh DwivediGhanshyam N PandeyDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 1, Pp 161-176 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yogesh Dwivedi Ghanshyam N Pandey Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A
description	Yogesh Dwivedi, Ghanshyam N PandeyPsychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USAAbstract: Mood disorders are among the most prevalent and recurrent forms of psychiatric illnesses. In the last decade, there has been increased understanding of the biological basis of mood disorders. In fact, novel mechanistic concepts of the neurobiology of unipolar and bipolar disorders are evolving based on recent pre-clinical and clinical studies, most of which now focus on the role of signal transduction mechanisms in these psychiatric illnesses. Particular investigative emphasis has been given to the role of phosphorylating enzymes, which are crucial in regulating gene expression and neuronal and synaptic plasticity. Among the most important phosphorylating enzyme is protein kinase A (PKA), a component of adenylyl cyclase&minus;cyclic adenosine monophosphate (AC&minus;cAMP) signaling system. In this review, we critically and comprehensively discuss the role of various components of AC&minus;cAMP signaling in mood disorders, with a special focus on PKA, because of the interesting observation that have been made about its involvement in unipolar and bipolar disorders. We also discuss the functional significance of the findings regarding PKA by discussing the role of important PKA substrates, namely, Rap-1, cyclicAMP-response element binding protein, and brain-derived neurotrophic factor. These studies suggest the interesting possibility that PKA and related signaling molecules may serve as important neurobiological factors in mood disorders and may be relevant in target-specific therapeutic interventions for these disorders.Keywords: protein kinase A, bipolar disorder, unipolar depression, CREB, BDNF, Rap-1
format	article
author	Yogesh Dwivedi Ghanshyam N Pandey
author_facet	Yogesh Dwivedi Ghanshyam N Pandey
author_sort	Yogesh Dwivedi
title	Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A
title_short	Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A
title_full	Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A
title_fullStr	Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A
title_full_unstemmed	Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A
title_sort	adenylyl cyclase-cyclicamp signaling in mood disorders: role of the crucial phosphorylating enzyme protein kinase a
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/53d843867aab41bd9cda2eef77a2bfd7
work_keys_str_mv	AT yogeshdwivedi adenylylcyclasecyclicampsignalinginmooddisordersroleofthecrucialphosphorylatingenzymeproteinkinasea AT ghanshyamnpandey adenylylcyclasecyclicampsignalinginmooddisordersroleofthecrucialphosphorylatingenzymeproteinkinasea
_version_	1718402041759399936

Adenylyl cyclase-cyclicAMP signaling in mood disorders: Role of the crucial phosphorylating enzyme protein kinase A

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