Neural correlates of delusional infestation responding to aripiprazole monotherapy: a case report

Laura Ponson,1,2 Frédéric Andersson,1 Wissam El-Hage1,2 1Université François-Rabelais de Tours, Inserm, Imagerie et Cerveau UMR U930, Tours, France, 2CHRU de Tours, Clinique Psychiatrique Universitaire, Tours, France Background: The pathophysiology and...

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Autores principales:	Ponson L, Andersson F, El-Hage W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/53dc66a9647848dea1a1bcc0abdaa91f
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spelling	oai:doaj.org-article:53dc66a9647848dea1a1bcc0abdaa91f2021-12-02T01:19:29ZNeural correlates of delusional infestation responding to aripiprazole monotherapy: a case report1178-2021https://doaj.org/article/53dc66a9647848dea1a1bcc0abdaa91f2015-02-01T00:00:00Zhttp://www.dovepress.com/neural-correlates-of-delusional-infestation-responding-to-aripiprazole-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021 Laura Ponson,1,2 Frédéric Andersson,1 Wissam El-Hage1,2 1Université François-Rabelais de Tours, Inserm, Imagerie et Cerveau UMR U930, Tours, France, 2CHRU de Tours, Clinique Psychiatrique Universitaire, Tours, France Background: The pathophysiology and appropriate pharmacological interventions for delusional infestation remain unknown.Case presentation: Here, we report a case of primary delusional infestation successfully treated with aripiprazole. We performed functional magnetic resonance imaging (fMRI) to investigate brain structures and functional modifications. Before antipsychotic treatment, pre- versus post-treatment fMRI images revealed a marked increase in brain activation in the supplementary motor area (SMA).Conclusion: Our results highlight the efficacy and safety of aripiprazole in the treatment of delusional infestation and the possible role of SMA dysfunction in delusional infestation. Indeed, our results suggest that psychiatric improvement of delusional infestation is associated with normalization of brain activity, particularly in the SMA. Keywords: supplementary motor area, antipsychotics, fMRIPonson LAndersson FEl-Hage WDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 257-261 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ponson L Andersson F El-Hage W Neural correlates of delusional infestation responding to aripiprazole monotherapy: a case report
description	Laura Ponson,1,2 Frédéric Andersson,1 Wissam El-Hage1,2 1Université François-Rabelais de Tours, Inserm, Imagerie et Cerveau UMR U930, Tours, France, 2CHRU de Tours, Clinique Psychiatrique Universitaire, Tours, France Background: The pathophysiology and appropriate pharmacological interventions for delusional infestation remain unknown.Case presentation: Here, we report a case of primary delusional infestation successfully treated with aripiprazole. We performed functional magnetic resonance imaging (fMRI) to investigate brain structures and functional modifications. Before antipsychotic treatment, pre- versus post-treatment fMRI images revealed a marked increase in brain activation in the supplementary motor area (SMA).Conclusion: Our results highlight the efficacy and safety of aripiprazole in the treatment of delusional infestation and the possible role of SMA dysfunction in delusional infestation. Indeed, our results suggest that psychiatric improvement of delusional infestation is associated with normalization of brain activity, particularly in the SMA. Keywords: supplementary motor area, antipsychotics, fMRI
format	article
author	Ponson L Andersson F El-Hage W
author_facet	Ponson L Andersson F El-Hage W
author_sort	Ponson L
title	Neural correlates of delusional infestation responding to aripiprazole monotherapy: a case report
title_short	Neural correlates of delusional infestation responding to aripiprazole monotherapy: a case report
title_full	Neural correlates of delusional infestation responding to aripiprazole monotherapy: a case report
title_fullStr	Neural correlates of delusional infestation responding to aripiprazole monotherapy: a case report
title_full_unstemmed	Neural correlates of delusional infestation responding to aripiprazole monotherapy: a case report
title_sort	neural correlates of delusional infestation responding to aripiprazole monotherapy: a case report
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/53dc66a9647848dea1a1bcc0abdaa91f
work_keys_str_mv	AT ponsonl neuralcorrelatesofdelusionalinfestationrespondingtoaripiprazolemonotherapyacasereport AT anderssonf neuralcorrelatesofdelusionalinfestationrespondingtoaripiprazolemonotherapyacasereport AT elhagew neuralcorrelatesofdelusionalinfestationrespondingtoaripiprazolemonotherapyacasereport
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Neural correlates of delusional infestation responding to aripiprazole monotherapy: a case report

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