Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes

Some individuals present with multiple synchronous colorectal tumours, but the genetic understanding of this is unclear. Here, the authors use a sequencing strategy to show that the synchronous tumours are genetically independent and the patients harbour rare germline damaging mutations in genes ass...

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Autores principales:	Matteo Cereda, Gennaro Gambardella, Lorena Benedetti, Fabio Iannelli, Dominic Patel, Gianluca Basso, Rosalinda F. Guerra, Thanos P. Mourikis, Ignazio Puccio, Shruti Sinha, Luigi Laghi, Jo Spencer, Manuel Rodriguez-Justo, Francesca D. Ciccarelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53dd8c3165584a758cf01d490afce229
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spelling	oai:doaj.org-article:53dd8c3165584a758cf01d490afce2292021-12-02T16:49:57ZPatients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes10.1038/ncomms120722041-1723https://doaj.org/article/53dd8c3165584a758cf01d490afce2292016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12072https://doaj.org/toc/2041-1723Some individuals present with multiple synchronous colorectal tumours, but the genetic understanding of this is unclear. Here, the authors use a sequencing strategy to show that the synchronous tumours are genetically independent and the patients harbour rare germline damaging mutations in genes associated with the immune system.Matteo CeredaGennaro GambardellaLorena BenedettiFabio IannelliDominic PatelGianluca BassoRosalinda F. GuerraThanos P. MourikisIgnazio PuccioShruti SinhaLuigi LaghiJo SpencerManuel Rodriguez-JustoFrancesca D. CiccarelliNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matteo Cereda Gennaro Gambardella Lorena Benedetti Fabio Iannelli Dominic Patel Gianluca Basso Rosalinda F. Guerra Thanos P. Mourikis Ignazio Puccio Shruti Sinha Luigi Laghi Jo Spencer Manuel Rodriguez-Justo Francesca D. Ciccarelli Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes
description	Some individuals present with multiple synchronous colorectal tumours, but the genetic understanding of this is unclear. Here, the authors use a sequencing strategy to show that the synchronous tumours are genetically independent and the patients harbour rare germline damaging mutations in genes associated with the immune system.
format	article
author	Matteo Cereda Gennaro Gambardella Lorena Benedetti Fabio Iannelli Dominic Patel Gianluca Basso Rosalinda F. Guerra Thanos P. Mourikis Ignazio Puccio Shruti Sinha Luigi Laghi Jo Spencer Manuel Rodriguez-Justo Francesca D. Ciccarelli
author_facet	Matteo Cereda Gennaro Gambardella Lorena Benedetti Fabio Iannelli Dominic Patel Gianluca Basso Rosalinda F. Guerra Thanos P. Mourikis Ignazio Puccio Shruti Sinha Luigi Laghi Jo Spencer Manuel Rodriguez-Justo Francesca D. Ciccarelli
author_sort	Matteo Cereda
title	Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes
title_short	Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes
title_full	Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes
title_fullStr	Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes
title_full_unstemmed	Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes
title_sort	patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/53dd8c3165584a758cf01d490afce229
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Patients with genetically heterogeneous synchronous colorectal cancer carry rare damaging germline mutations in immune-related genes

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