Combination of Porous Silk Fibroin Substrate and Gold Nanocracks as a Novel SERS Platform for a High-Sensitivity Biosensor

Novel concepts for developing a surface-enhanced Raman scattering (SERS) sensor based on biocompatible materials offer great potential in versatile applications, including wearable and in vivo monitoring of target analytes. Here, we report a highly sensitive SERS sensor consisting of a biocompatible...

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Autores principales:	Ji Hyeon Choi, Munsik Choi, Taeyoung Kang, Tien Son Ho, Seung Ho Choi, Kyung Min Byun
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	silk fibroin porous gold nanocracks surface-enhanced Raman scattering sensitive overlap integral Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/53df50f9e19f43e5980ac5ff5cafc688
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spelling	oai:doaj.org-article:53df50f9e19f43e5980ac5ff5cafc6882021-11-25T16:55:25ZCombination of Porous Silk Fibroin Substrate and Gold Nanocracks as a Novel SERS Platform for a High-Sensitivity Biosensor10.3390/bios111104412079-6374https://doaj.org/article/53df50f9e19f43e5980ac5ff5cafc6882021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6374/11/11/441https://doaj.org/toc/2079-6374Novel concepts for developing a surface-enhanced Raman scattering (SERS) sensor based on biocompatible materials offer great potential in versatile applications, including wearable and in vivo monitoring of target analytes. Here, we report a highly sensitive SERS sensor consisting of a biocompatible silk fibroin substrate with a high porosity and gold nanocracks. Our silk-based SERS detection takes advantage of strong local field enhancement in the nanoscale crack regions induced by gold nanostructures evaporated on a porous silk substrate. The SERS performance of the proposed sensor is evaluated in terms of detection limit, sensitivity, and linearity. Compared to the performance of a counterpart SERS sensor with a thin gold film, SERS results using 4-ABT analytes present that a significant improvement in the detection limit and sensitivity by more than 4 times, and a good linearity and a wide dynamic range is achieved. More interestingly, overlap is integral, and a quantitative measure of the local field enhancement is highly consistent with the experimental SERS enhancement.Ji Hyeon ChoiMunsik ChoiTaeyoung KangTien Son HoSeung Ho ChoiKyung Min ByunMDPI AGarticlesilk fibroinporousgold nanocrackssurface-enhanced Raman scatteringsensitiveoverlap integralBiotechnologyTP248.13-248.65ENBiosensors, Vol 11, Iss 441, p 441 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	silk fibroin porous gold nanocracks surface-enhanced Raman scattering sensitive overlap integral Biotechnology TP248.13-248.65
spellingShingle	silk fibroin porous gold nanocracks surface-enhanced Raman scattering sensitive overlap integral Biotechnology TP248.13-248.65 Ji Hyeon Choi Munsik Choi Taeyoung Kang Tien Son Ho Seung Ho Choi Kyung Min Byun Combination of Porous Silk Fibroin Substrate and Gold Nanocracks as a Novel SERS Platform for a High-Sensitivity Biosensor
description	Novel concepts for developing a surface-enhanced Raman scattering (SERS) sensor based on biocompatible materials offer great potential in versatile applications, including wearable and in vivo monitoring of target analytes. Here, we report a highly sensitive SERS sensor consisting of a biocompatible silk fibroin substrate with a high porosity and gold nanocracks. Our silk-based SERS detection takes advantage of strong local field enhancement in the nanoscale crack regions induced by gold nanostructures evaporated on a porous silk substrate. The SERS performance of the proposed sensor is evaluated in terms of detection limit, sensitivity, and linearity. Compared to the performance of a counterpart SERS sensor with a thin gold film, SERS results using 4-ABT analytes present that a significant improvement in the detection limit and sensitivity by more than 4 times, and a good linearity and a wide dynamic range is achieved. More interestingly, overlap is integral, and a quantitative measure of the local field enhancement is highly consistent with the experimental SERS enhancement.
format	article
author	Ji Hyeon Choi Munsik Choi Taeyoung Kang Tien Son Ho Seung Ho Choi Kyung Min Byun
author_facet	Ji Hyeon Choi Munsik Choi Taeyoung Kang Tien Son Ho Seung Ho Choi Kyung Min Byun
author_sort	Ji Hyeon Choi
title	Combination of Porous Silk Fibroin Substrate and Gold Nanocracks as a Novel SERS Platform for a High-Sensitivity Biosensor
title_short	Combination of Porous Silk Fibroin Substrate and Gold Nanocracks as a Novel SERS Platform for a High-Sensitivity Biosensor
title_full	Combination of Porous Silk Fibroin Substrate and Gold Nanocracks as a Novel SERS Platform for a High-Sensitivity Biosensor
title_fullStr	Combination of Porous Silk Fibroin Substrate and Gold Nanocracks as a Novel SERS Platform for a High-Sensitivity Biosensor
title_full_unstemmed	Combination of Porous Silk Fibroin Substrate and Gold Nanocracks as a Novel SERS Platform for a High-Sensitivity Biosensor
title_sort	combination of porous silk fibroin substrate and gold nanocracks as a novel sers platform for a high-sensitivity biosensor
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/53df50f9e19f43e5980ac5ff5cafc688
work_keys_str_mv	AT jihyeonchoi combinationofporoussilkfibroinsubstrateandgoldnanocracksasanovelsersplatformforahighsensitivitybiosensor AT munsikchoi combinationofporoussilkfibroinsubstrateandgoldnanocracksasanovelsersplatformforahighsensitivitybiosensor AT taeyoungkang combinationofporoussilkfibroinsubstrateandgoldnanocracksasanovelsersplatformforahighsensitivitybiosensor AT tiensonho combinationofporoussilkfibroinsubstrateandgoldnanocracksasanovelsersplatformforahighsensitivitybiosensor AT seunghochoi combinationofporoussilkfibroinsubstrateandgoldnanocracksasanovelsersplatformforahighsensitivitybiosensor AT kyungminbyun combinationofporoussilkfibroinsubstrateandgoldnanocracksasanovelsersplatformforahighsensitivitybiosensor
_version_	1718412836431986688

Combination of Porous Silk Fibroin Substrate and Gold Nanocracks as a Novel SERS Platform for a High-Sensitivity Biosensor

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