Antimalarial activity of primaquine operates via a two-step biochemical relay

Primaquine (PQ) is a widely used anti-malaria drug, but its mechanism of action is unclear. Here, Camarda et al. show that PQ’s activity against liver and sexual Plasmodium stages depends on generation of hydroxylated-PQ metabolites (OH-PQm), which, undergoing further reactions, results in productio...

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Autores principales:	Grazia Camarda, Piyaporn Jirawatcharadech, Richard S. Priestley, Ahmed Saif, Sandra March, Michael H. L. Wong, Suet Leung, Alex B. Miller, David A. Baker, Pietro Alano, Mark J. I. Paine, Sangeeta N. Bhatia, Paul M. O’Neill, Stephen A. Ward, Giancarlo A. Biagini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/53df786506df4fffaf54431621d57eba
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spelling	oai:doaj.org-article:53df786506df4fffaf54431621d57eba2021-12-02T16:58:28ZAntimalarial activity of primaquine operates via a two-step biochemical relay10.1038/s41467-019-11239-02041-1723https://doaj.org/article/53df786506df4fffaf54431621d57eba2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11239-0https://doaj.org/toc/2041-1723Primaquine (PQ) is a widely used anti-malaria drug, but its mechanism of action is unclear. Here, Camarda et al. show that PQ’s activity against liver and sexual Plasmodium stages depends on generation of hydroxylated-PQ metabolites (OH-PQm), which, undergoing further reactions, results in production of H2O2.Grazia CamardaPiyaporn JirawatcharadechRichard S. PriestleyAhmed SaifSandra MarchMichael H. L. WongSuet LeungAlex B. MillerDavid A. BakerPietro AlanoMark J. I. PaineSangeeta N. BhatiaPaul M. O’NeillStephen A. WardGiancarlo A. BiaginiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Grazia Camarda Piyaporn Jirawatcharadech Richard S. Priestley Ahmed Saif Sandra March Michael H. L. Wong Suet Leung Alex B. Miller David A. Baker Pietro Alano Mark J. I. Paine Sangeeta N. Bhatia Paul M. O’Neill Stephen A. Ward Giancarlo A. Biagini Antimalarial activity of primaquine operates via a two-step biochemical relay
description	Primaquine (PQ) is a widely used anti-malaria drug, but its mechanism of action is unclear. Here, Camarda et al. show that PQ’s activity against liver and sexual Plasmodium stages depends on generation of hydroxylated-PQ metabolites (OH-PQm), which, undergoing further reactions, results in production of H2O2.
format	article
author	Grazia Camarda Piyaporn Jirawatcharadech Richard S. Priestley Ahmed Saif Sandra March Michael H. L. Wong Suet Leung Alex B. Miller David A. Baker Pietro Alano Mark J. I. Paine Sangeeta N. Bhatia Paul M. O’Neill Stephen A. Ward Giancarlo A. Biagini
author_facet	Grazia Camarda Piyaporn Jirawatcharadech Richard S. Priestley Ahmed Saif Sandra March Michael H. L. Wong Suet Leung Alex B. Miller David A. Baker Pietro Alano Mark J. I. Paine Sangeeta N. Bhatia Paul M. O’Neill Stephen A. Ward Giancarlo A. Biagini
author_sort	Grazia Camarda
title	Antimalarial activity of primaquine operates via a two-step biochemical relay
title_short	Antimalarial activity of primaquine operates via a two-step biochemical relay
title_full	Antimalarial activity of primaquine operates via a two-step biochemical relay
title_fullStr	Antimalarial activity of primaquine operates via a two-step biochemical relay
title_full_unstemmed	Antimalarial activity of primaquine operates via a two-step biochemical relay
title_sort	antimalarial activity of primaquine operates via a two-step biochemical relay
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/53df786506df4fffaf54431621d57eba
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Antimalarial activity of primaquine operates via a two-step biochemical relay

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