Endothelin neurotransmitter signalling controls zebrafish social behaviour

Abstract The formation of social groups is an adaptive behaviour that can provide protection from predators, improve foraging and facilitate social learning. However, the costs of proximity can include competition for resources, aggression and kleptoparasitism meaning that the decision whether to in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Héctor Carreño Gutiérrez, Sarah Colanesi, Ben Cooper, Florian Reichmann, Andrew M. J. Young, Robert N. Kelsh, William H. J. Norton
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/53e16a7b6f854de5988e0cf8e3e555cd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:53e16a7b6f854de5988e0cf8e3e555cd
record_format	dspace
spelling	oai:doaj.org-article:53e16a7b6f854de5988e0cf8e3e555cd2021-12-02T15:08:46ZEndothelin neurotransmitter signalling controls zebrafish social behaviour10.1038/s41598-019-39907-72045-2322https://doaj.org/article/53e16a7b6f854de5988e0cf8e3e555cd2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-39907-7https://doaj.org/toc/2045-2322Abstract The formation of social groups is an adaptive behaviour that can provide protection from predators, improve foraging and facilitate social learning. However, the costs of proximity can include competition for resources, aggression and kleptoparasitism meaning that the decision whether to interact represents a trade-off. Here we show that zebrafish harbouring a mutation in endothelin receptor aa (ednraa) form less cohesive shoals than wild-types. ednraa −/− mutants exhibit heightened aggression and decreased whole-body cortisol levels suggesting that they are dominant. These behavioural changes correlate with a reduction of parvocellular arginine vasopressin (AVP)-positive neurons in the preoptic area, an increase in the size of magnocellular AVP neurons and a higher concentration of 5-HT and dopamine in the brain. Manipulation of AVP or 5-HT signalling can rescue the shoaling phenotype of ednraa −/− providing an insight into how the brain controls social interactions.Héctor Carreño GutiérrezSarah ColanesiBen CooperFlorian ReichmannAndrew M. J. YoungRobert N. KelshWilliam H. J. NortonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Héctor Carreño Gutiérrez Sarah Colanesi Ben Cooper Florian Reichmann Andrew M. J. Young Robert N. Kelsh William H. J. Norton Endothelin neurotransmitter signalling controls zebrafish social behaviour
description	Abstract The formation of social groups is an adaptive behaviour that can provide protection from predators, improve foraging and facilitate social learning. However, the costs of proximity can include competition for resources, aggression and kleptoparasitism meaning that the decision whether to interact represents a trade-off. Here we show that zebrafish harbouring a mutation in endothelin receptor aa (ednraa) form less cohesive shoals than wild-types. ednraa −/− mutants exhibit heightened aggression and decreased whole-body cortisol levels suggesting that they are dominant. These behavioural changes correlate with a reduction of parvocellular arginine vasopressin (AVP)-positive neurons in the preoptic area, an increase in the size of magnocellular AVP neurons and a higher concentration of 5-HT and dopamine in the brain. Manipulation of AVP or 5-HT signalling can rescue the shoaling phenotype of ednraa −/− providing an insight into how the brain controls social interactions.
format	article
author	Héctor Carreño Gutiérrez Sarah Colanesi Ben Cooper Florian Reichmann Andrew M. J. Young Robert N. Kelsh William H. J. Norton
author_facet	Héctor Carreño Gutiérrez Sarah Colanesi Ben Cooper Florian Reichmann Andrew M. J. Young Robert N. Kelsh William H. J. Norton
author_sort	Héctor Carreño Gutiérrez
title	Endothelin neurotransmitter signalling controls zebrafish social behaviour
title_short	Endothelin neurotransmitter signalling controls zebrafish social behaviour
title_full	Endothelin neurotransmitter signalling controls zebrafish social behaviour
title_fullStr	Endothelin neurotransmitter signalling controls zebrafish social behaviour
title_full_unstemmed	Endothelin neurotransmitter signalling controls zebrafish social behaviour
title_sort	endothelin neurotransmitter signalling controls zebrafish social behaviour
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/53e16a7b6f854de5988e0cf8e3e555cd
work_keys_str_mv	AT hectorcarrenogutierrez endothelinneurotransmittersignallingcontrolszebrafishsocialbehaviour AT sarahcolanesi endothelinneurotransmittersignallingcontrolszebrafishsocialbehaviour AT bencooper endothelinneurotransmittersignallingcontrolszebrafishsocialbehaviour AT florianreichmann endothelinneurotransmittersignallingcontrolszebrafishsocialbehaviour AT andrewmjyoung endothelinneurotransmittersignallingcontrolszebrafishsocialbehaviour AT robertnkelsh endothelinneurotransmittersignallingcontrolszebrafishsocialbehaviour AT williamhjnorton endothelinneurotransmittersignallingcontrolszebrafishsocialbehaviour
_version_	1718387997691346944

Endothelin neurotransmitter signalling controls zebrafish social behaviour

Ejemplares similares