Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area

Purpose. We examined the relationships between pattern electroretinogram and optical coherence tomography derived optic nerve head measurements, after controlling for disc area. Methods. Thirty-two eyes from 20 subjects with preperimetric glaucoma underwent pattern electroretinogram and optical cohe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Andrew Tirsi, Vasiliki Gliagias, Julie Moehringer, Derek Orshan, Sofia Tello, Peter Derr, Sung Chul Park, Stephen A Obstbaum, Celso Tello
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/53e1a424306f4dd2b468a46640e44ea0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:53e1a424306f4dd2b468a46640e44ea0
record_format	dspace
spelling	oai:doaj.org-article:53e1a424306f4dd2b468a46640e44ea02021-11-29T00:57:14ZPattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area2090-005810.1155/2021/8025337https://doaj.org/article/53e1a424306f4dd2b468a46640e44ea02021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8025337https://doaj.org/toc/2090-0058Purpose. We examined the relationships between pattern electroretinogram and optical coherence tomography derived optic nerve head measurements, after controlling for disc area. Methods. Thirty-two eyes from 20 subjects with preperimetric glaucoma underwent pattern electroretinogram and optical coherence tomography. Pattern electroretinogram parameters (Magnitude, MagnitudeD, and MagnitudeD/Magnitude ratio) and optic nerve head measurements (rim area, average cup to disc ratio, vertical cup to disc ratio, cup volume, retinal nerve fiber layer thickness sectors, and Bruch’s membrane opening-minimum rim width thickness sectors) were analyzed after controlling for disc area. Results. Magnitude and MagnitudeD were significantly associated with rim area (r ≥ 0.503, p≤0.004). All pattern electroretinogram parameters significantly correlated with Bruch’s membrane opening-minimum rim width sectors—temporal superior and nasal inferior (r = 0.400, p=0.039)—and retinal nerve fiber layer sectors—superior, nasal superior, and inferior (r ≥ 0.428, p≤0.026). Magnitude and MagnitudeD explained an additional 26.8% and 25.2% of variance in rim area (B = 0.174 (95% CI: 0.065, 0.283), p=0.003, and B = 0.160 (95% CI: 0.056, 0.265), p=0.004), respectively. MagnitudeD and MagnitudeD/Magnitude ratio explained an additional 13.4% and 12.8% of the variance in Bruch’s membrane opening-minimum rim width global (B = 38.921 [95% CI: 3.872, 73.970], p=0.031, and B = 129.024 (95% CI: 9.589, 248.460), p=0.035), respectively. All Bruch’s membrane opening-minimum rim width sectors and retinal nerve fiber layer sectors (nasal superior, nasal inferior, and inferior) were significantly correlated with rim area (r ≥ 0.389, p≤0.045). Conclusion. PERG abnormalities can predict rim area loss in preperimetric glaucoma after controlling for disc area. We recommend controlling for disc area to increase diagnostic accuracy in early glaucoma.Andrew TirsiVasiliki GliagiasJulie MoehringerDerek OrshanSofia TelloPeter DerrSung Chul ParkStephen A ObstbaumCelso TelloHindawi LimitedarticleOphthalmologyRE1-994ENJournal of Ophthalmology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Andrew Tirsi Vasiliki Gliagias Julie Moehringer Derek Orshan Sofia Tello Peter Derr Sung Chul Park Stephen A Obstbaum Celso Tello Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area
description	Purpose. We examined the relationships between pattern electroretinogram and optical coherence tomography derived optic nerve head measurements, after controlling for disc area. Methods. Thirty-two eyes from 20 subjects with preperimetric glaucoma underwent pattern electroretinogram and optical coherence tomography. Pattern electroretinogram parameters (Magnitude, MagnitudeD, and MagnitudeD/Magnitude ratio) and optic nerve head measurements (rim area, average cup to disc ratio, vertical cup to disc ratio, cup volume, retinal nerve fiber layer thickness sectors, and Bruch’s membrane opening-minimum rim width thickness sectors) were analyzed after controlling for disc area. Results. Magnitude and MagnitudeD were significantly associated with rim area (r ≥ 0.503, p≤0.004). All pattern electroretinogram parameters significantly correlated with Bruch’s membrane opening-minimum rim width sectors—temporal superior and nasal inferior (r = 0.400, p=0.039)—and retinal nerve fiber layer sectors—superior, nasal superior, and inferior (r ≥ 0.428, p≤0.026). Magnitude and MagnitudeD explained an additional 26.8% and 25.2% of variance in rim area (B = 0.174 (95% CI: 0.065, 0.283), p=0.003, and B = 0.160 (95% CI: 0.056, 0.265), p=0.004), respectively. MagnitudeD and MagnitudeD/Magnitude ratio explained an additional 13.4% and 12.8% of the variance in Bruch’s membrane opening-minimum rim width global (B = 38.921 [95% CI: 3.872, 73.970], p=0.031, and B = 129.024 (95% CI: 9.589, 248.460), p=0.035), respectively. All Bruch’s membrane opening-minimum rim width sectors and retinal nerve fiber layer sectors (nasal superior, nasal inferior, and inferior) were significantly correlated with rim area (r ≥ 0.389, p≤0.045). Conclusion. PERG abnormalities can predict rim area loss in preperimetric glaucoma after controlling for disc area. We recommend controlling for disc area to increase diagnostic accuracy in early glaucoma.
format	article
author	Andrew Tirsi Vasiliki Gliagias Julie Moehringer Derek Orshan Sofia Tello Peter Derr Sung Chul Park Stephen A Obstbaum Celso Tello
author_facet	Andrew Tirsi Vasiliki Gliagias Julie Moehringer Derek Orshan Sofia Tello Peter Derr Sung Chul Park Stephen A Obstbaum Celso Tello
author_sort	Andrew Tirsi
title	Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area
title_short	Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area
title_full	Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area
title_fullStr	Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area
title_full_unstemmed	Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area
title_sort	pattern electroretinogram parameters are associated with optic nerve morphology in preperimetric glaucoma after adjusting for disc area
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/53e1a424306f4dd2b468a46640e44ea0
work_keys_str_mv	AT andrewtirsi patternelectroretinogramparametersareassociatedwithopticnervemorphologyinpreperimetricglaucomaafteradjustingfordiscarea AT vasilikigliagias patternelectroretinogramparametersareassociatedwithopticnervemorphologyinpreperimetricglaucomaafteradjustingfordiscarea AT juliemoehringer patternelectroretinogramparametersareassociatedwithopticnervemorphologyinpreperimetricglaucomaafteradjustingfordiscarea AT derekorshan patternelectroretinogramparametersareassociatedwithopticnervemorphologyinpreperimetricglaucomaafteradjustingfordiscarea AT sofiatello patternelectroretinogramparametersareassociatedwithopticnervemorphologyinpreperimetricglaucomaafteradjustingfordiscarea AT peterderr patternelectroretinogramparametersareassociatedwithopticnervemorphologyinpreperimetricglaucomaafteradjustingfordiscarea AT sungchulpark patternelectroretinogramparametersareassociatedwithopticnervemorphologyinpreperimetricglaucomaafteradjustingfordiscarea AT stephenaobstbaum patternelectroretinogramparametersareassociatedwithopticnervemorphologyinpreperimetricglaucomaafteradjustingfordiscarea AT celsotello patternelectroretinogramparametersareassociatedwithopticnervemorphologyinpreperimetricglaucomaafteradjustingfordiscarea
_version_	1718407643519778816

Pattern Electroretinogram Parameters Are Associated with Optic Nerve Morphology in Preperimetric Glaucoma after Adjusting for Disc Area

Ejemplares similares