LIVE ATTENUATED VACCINES FOR THE IMMUNOPROPHYLAXIS

The review focuses on the history of the production of live antiviral vaccines and their use for the prevention of infectious diseases. It was noted that before the beginning of the 20th century, only three live vaccines were developed and put into practice — against smallpox, rabies, plague. The di...

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Autor principal:	O. A. Shamsutdinova
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2017
Materias:	monovaccines associated vaccines live vaccines incidence vaccine strains poliomyelitis measles rubella mumps vaccine prophylaxis Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/53e1df8ec355427ca1ecba37ed111e36
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spelling	oai:doaj.org-article:53e1df8ec355427ca1ecba37ed111e362021-11-22T07:09:48ZLIVE ATTENUATED VACCINES FOR THE IMMUNOPROPHYLAXIS2220-76192313-739810.15789/2220-7619-2017-2-107-116https://doaj.org/article/53e1df8ec355427ca1ecba37ed111e362017-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/510https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398The review focuses on the history of the production of live antiviral vaccines and their use for the prevention of infectious diseases. It was noted that before the beginning of the 20th century, only three live vaccines were developed and put into practice — against smallpox, rabies, plague. The discovery of D. Enders, T.H. Weller and F.Ch. Robins of the ability of the polio virus, and then of a number of other viruses, to reproduce in vitro in cell cultures of various types, greatly expanded the studies on the production of attenuated strains of viruses for live vaccines. The historical stages of obtaining and introducing live vaccines for the prevention of smallpox, poliomyelitis, measles, rubella, and mumps are highlighted. Arguments in favor of the use of associated vaccine preparations for the prevention of viral infections are presented. Various variants of the strategy and tactics of using live vaccines, which are used for specific prevention of viral infections in different countries, are described. The review provides information on technological methods for obtaining antiviral vaccines. The publications testifying to the development of specific reactions in immunized vaccine strains of measles, mumps, poliomyelitis and rubella viruses, such as aseptic meningitis (vaccine strains of mumps virus), acute arthritis (vaccine rubella virus strains), temperature reactions, rash (vaccine strains of the virus Measles), vaccine-associated paralytic poliomyelitis (VAPP) vaccine vaccine poliovirus. It is particularly noted that the long experience of vaccine prevention both in Russia and abroad convincingly shows that the risk of developing post-vaccination complications is incommensurably lower than the risk of causing harm to health from the corresponding infections. It is concluded that despite introduction of new third and fourth generation vaccines into practice, live attenuated vaccines do not lose their significance and are used in vaccine-preventable infections as the most effective immunobiological drugs.O. A. ShamsutdinovaSankt-Peterburg : NIIÈM imeni Pasteraarticlemonovaccinesassociated vaccineslive vaccinesincidencevaccine strainspoliomyelitismeaslesrubellamumpsvaccine prophylaxisInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 7, Iss 2, Pp 107-116 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	monovaccines associated vaccines live vaccines incidence vaccine strains poliomyelitis measles rubella mumps vaccine prophylaxis Infectious and parasitic diseases RC109-216
spellingShingle	monovaccines associated vaccines live vaccines incidence vaccine strains poliomyelitis measles rubella mumps vaccine prophylaxis Infectious and parasitic diseases RC109-216 O. A. Shamsutdinova LIVE ATTENUATED VACCINES FOR THE IMMUNOPROPHYLAXIS
description	The review focuses on the history of the production of live antiviral vaccines and their use for the prevention of infectious diseases. It was noted that before the beginning of the 20th century, only three live vaccines were developed and put into practice — against smallpox, rabies, plague. The discovery of D. Enders, T.H. Weller and F.Ch. Robins of the ability of the polio virus, and then of a number of other viruses, to reproduce in vitro in cell cultures of various types, greatly expanded the studies on the production of attenuated strains of viruses for live vaccines. The historical stages of obtaining and introducing live vaccines for the prevention of smallpox, poliomyelitis, measles, rubella, and mumps are highlighted. Arguments in favor of the use of associated vaccine preparations for the prevention of viral infections are presented. Various variants of the strategy and tactics of using live vaccines, which are used for specific prevention of viral infections in different countries, are described. The review provides information on technological methods for obtaining antiviral vaccines. The publications testifying to the development of specific reactions in immunized vaccine strains of measles, mumps, poliomyelitis and rubella viruses, such as aseptic meningitis (vaccine strains of mumps virus), acute arthritis (vaccine rubella virus strains), temperature reactions, rash (vaccine strains of the virus Measles), vaccine-associated paralytic poliomyelitis (VAPP) vaccine vaccine poliovirus. It is particularly noted that the long experience of vaccine prevention both in Russia and abroad convincingly shows that the risk of developing post-vaccination complications is incommensurably lower than the risk of causing harm to health from the corresponding infections. It is concluded that despite introduction of new third and fourth generation vaccines into practice, live attenuated vaccines do not lose their significance and are used in vaccine-preventable infections as the most effective immunobiological drugs.
format	article
author	O. A. Shamsutdinova
author_facet	O. A. Shamsutdinova
author_sort	O. A. Shamsutdinova
title	LIVE ATTENUATED VACCINES FOR THE IMMUNOPROPHYLAXIS
title_short	LIVE ATTENUATED VACCINES FOR THE IMMUNOPROPHYLAXIS
title_full	LIVE ATTENUATED VACCINES FOR THE IMMUNOPROPHYLAXIS
title_fullStr	LIVE ATTENUATED VACCINES FOR THE IMMUNOPROPHYLAXIS
title_full_unstemmed	LIVE ATTENUATED VACCINES FOR THE IMMUNOPROPHYLAXIS
title_sort	live attenuated vaccines for the immunoprophylaxis
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2017
url	https://doaj.org/article/53e1df8ec355427ca1ecba37ed111e36
work_keys_str_mv	AT oashamsutdinova liveattenuatedvaccinesfortheimmunoprophylaxis
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LIVE ATTENUATED VACCINES FOR THE IMMUNOPROPHYLAXIS

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