Gender differences in relation to hyperuricemia and nonalcoholic fatty liver disease among Type 2 diabetics in Telangana, India

Background: Scarcity of data in relationship between hyperuricemia and nonalcoholic fatty liver disease (NAFLD) in Type 2 diabetics (T2DM), particularly in terms of gender differences. Hence, the study was aimed to investigate the gender difference in association between hyperuricemia, and NAFLD in...

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Autores principales:	Usha Sree Puneem, Subburaya Mudaliyar Rajendran Ramakrishnan, Vasudeva Murthy Sindgi, Vanitha Rani Nagasubramanian
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Serum uric acid NAFLD Type-2 diabetes Gender difference Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/53e2812fa811429187a63f0be5e113a6
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spelling	oai:doaj.org-article:53e2812fa811429187a63f0be5e113a62021-11-04T04:30:33ZGender differences in relation to hyperuricemia and nonalcoholic fatty liver disease among Type 2 diabetics in Telangana, India2213-398410.1016/j.cegh.2021.100879https://doaj.org/article/53e2812fa811429187a63f0be5e113a62021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213398421001871https://doaj.org/toc/2213-3984Background: Scarcity of data in relationship between hyperuricemia and nonalcoholic fatty liver disease (NAFLD) in Type 2 diabetics (T2DM), particularly in terms of gender differences. Hence, the study was aimed to investigate the gender difference in association between hyperuricemia, and NAFLD in the Indian population. Methodology: A cross-sectional study was conducted with 134 Indian adults, of which 93 males and 41were females. Among them hyperurecemics are 66 (71%) males and 26 (63%) are females. The sample was collected at the department of gastroenterology. The student t-test was applied to assess the risk of hyper and non-hyperuricemia among the NAFLD in Type-2 diabetics. Pearson correlation was used to assess link between serum uric acid and other biochemical parameters. Results: The BMI, SGOT, ALP and LDL levels are significantly elevated in hyperuricemia male subjects (P < 0.05). Triglyceride levels had a weak negative correlation with serum uric acid (SUA) levels, which was significant in male NAFLD subjects (P 0.01). The overall prevalence of hyperuricemia was more in males as compared with females (P < 0.05). Conclusion: Our results reveal that the dyslipidemia is more closely associated with hyperuricemia in men than women with NAFLD. Total cholesterol and Triglycerides showed significant weak negative correlation with SUA in males. Further longitudinal studies are required to prove these findings.Usha Sree PuneemSubburaya Mudaliyar Rajendran RamakrishnanVasudeva Murthy SindgiVanitha Rani NagasubramanianElsevierarticleSerum uric acidNAFLDType-2 diabetesGender differencePublic aspects of medicineRA1-1270ENClinical Epidemiology and Global Health, Vol 12, Iss , Pp 100879- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Serum uric acid NAFLD Type-2 diabetes Gender difference Public aspects of medicine RA1-1270
spellingShingle	Serum uric acid NAFLD Type-2 diabetes Gender difference Public aspects of medicine RA1-1270 Usha Sree Puneem Subburaya Mudaliyar Rajendran Ramakrishnan Vasudeva Murthy Sindgi Vanitha Rani Nagasubramanian Gender differences in relation to hyperuricemia and nonalcoholic fatty liver disease among Type 2 diabetics in Telangana, India
description	Background: Scarcity of data in relationship between hyperuricemia and nonalcoholic fatty liver disease (NAFLD) in Type 2 diabetics (T2DM), particularly in terms of gender differences. Hence, the study was aimed to investigate the gender difference in association between hyperuricemia, and NAFLD in the Indian population. Methodology: A cross-sectional study was conducted with 134 Indian adults, of which 93 males and 41were females. Among them hyperurecemics are 66 (71%) males and 26 (63%) are females. The sample was collected at the department of gastroenterology. The student t-test was applied to assess the risk of hyper and non-hyperuricemia among the NAFLD in Type-2 diabetics. Pearson correlation was used to assess link between serum uric acid and other biochemical parameters. Results: The BMI, SGOT, ALP and LDL levels are significantly elevated in hyperuricemia male subjects (P < 0.05). Triglyceride levels had a weak negative correlation with serum uric acid (SUA) levels, which was significant in male NAFLD subjects (P 0.01). The overall prevalence of hyperuricemia was more in males as compared with females (P < 0.05). Conclusion: Our results reveal that the dyslipidemia is more closely associated with hyperuricemia in men than women with NAFLD. Total cholesterol and Triglycerides showed significant weak negative correlation with SUA in males. Further longitudinal studies are required to prove these findings.
format	article
author	Usha Sree Puneem Subburaya Mudaliyar Rajendran Ramakrishnan Vasudeva Murthy Sindgi Vanitha Rani Nagasubramanian
author_facet	Usha Sree Puneem Subburaya Mudaliyar Rajendran Ramakrishnan Vasudeva Murthy Sindgi Vanitha Rani Nagasubramanian
author_sort	Usha Sree Puneem
title	Gender differences in relation to hyperuricemia and nonalcoholic fatty liver disease among Type 2 diabetics in Telangana, India
title_short	Gender differences in relation to hyperuricemia and nonalcoholic fatty liver disease among Type 2 diabetics in Telangana, India
title_full	Gender differences in relation to hyperuricemia and nonalcoholic fatty liver disease among Type 2 diabetics in Telangana, India
title_fullStr	Gender differences in relation to hyperuricemia and nonalcoholic fatty liver disease among Type 2 diabetics in Telangana, India
title_full_unstemmed	Gender differences in relation to hyperuricemia and nonalcoholic fatty liver disease among Type 2 diabetics in Telangana, India
title_sort	gender differences in relation to hyperuricemia and nonalcoholic fatty liver disease among type 2 diabetics in telangana, india
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/53e2812fa811429187a63f0be5e113a6
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Gender differences in relation to hyperuricemia and nonalcoholic fatty liver disease among Type 2 diabetics in Telangana, India

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