Microarray analysis reveals ONC201 mediated differential mechanisms of CHOP gene regulation in metastatic and nonmetastatic colorectal cancer cells

Microarray analysis reveals ONC201 mediated differential mechanisms of CHOP gene regulation in metastatic and nonmetastatic colorectal cancer cells

Abstract The imipramine ONC201 has antiproliferative effects in several cancer cell types and activates integrated stress response pathway associated with the induction of Damage Inducible Transcript 3 (DDIT3, also known as C/EBP homologous protein or CHOP). We investigated the signaling pathways th...

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Autores principales: Ashraf Al Madhoun, Dania Haddad, Mustafa Al Tarrah, Sindhu Jacob, Waleed Al-Ali, Rasheeba Nizam, Lavina Miranda, Fatema Al-Rashed, Sardar Sindhu, Rasheed Ahmad, Milad S. Bitar, Fahd Al-Mulla
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/53e9a71543dd4eab8fa13a04b1da0202
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