Clinical characteristics and factors associated with triple therapy use in newly diagnosed patients with COPD

Abstract There is limited information about the initiation of triple therapy (TT) in patients with chronic obstructive pulmonary disease (COPD) in primary care. This was an observational, population-based study in patients identified from a primary care electronic medical records database in Catalon...

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Autores principales:	Mònica Monteagudo, Miriam Barrecheguren, Iryna Solntseva, Nafeesa Dhalwani, Alison Booth, Alexa Nuñez, Dimitra Lambrelli, Marc Miravitlles
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/53f3eceade6c4e54a4020da3b4fd6f5a
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spelling	oai:doaj.org-article:53f3eceade6c4e54a4020da3b4fd6f5a2021-12-02T16:36:11ZClinical characteristics and factors associated with triple therapy use in newly diagnosed patients with COPD10.1038/s41533-021-00227-x2055-1010https://doaj.org/article/53f3eceade6c4e54a4020da3b4fd6f5a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41533-021-00227-xhttps://doaj.org/toc/2055-1010Abstract There is limited information about the initiation of triple therapy (TT) in patients with chronic obstructive pulmonary disease (COPD) in primary care. This was an observational, population-based study in patients identified from a primary care electronic medical records database in Catalonia from 2011 to 2015 aimed to identify the use of TT in patients with newly diagnosed COPD. A total of 69,668 newly diagnosed patients were identified of whom 11,524 (16.5%) initiated TT, of whom 8626 initiated TT at or immediately after COPD diagnosis. Among them, 72.3% were GOLD A/B, 14.6% were frequent exacerbators, and 7.1% had asthma–COPD overlap (ACO). Variables associated with TT initiation were: male sex, older age, previous exacerbations, ACO, a previous treatment regimen containing an inhaled corticosteroid, previous pneumonia, and history of lung cancer. A significant number of COPD patients in Primary Care initiated TT shortly after or even before an established COPD diagnosis.Mònica MonteagudoMiriam BarrechegurenIryna SolntsevaNafeesa DhalwaniAlison BoothAlexa NuñezDimitra LambrelliMarc MiravitllesNature PortfolioarticleDiseases of the respiratory systemRC705-779ENnpj Primary Care Respiratory Medicine, Vol 31, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the respiratory system RC705-779
spellingShingle	Diseases of the respiratory system RC705-779 Mònica Monteagudo Miriam Barrecheguren Iryna Solntseva Nafeesa Dhalwani Alison Booth Alexa Nuñez Dimitra Lambrelli Marc Miravitlles Clinical characteristics and factors associated with triple therapy use in newly diagnosed patients with COPD
description	Abstract There is limited information about the initiation of triple therapy (TT) in patients with chronic obstructive pulmonary disease (COPD) in primary care. This was an observational, population-based study in patients identified from a primary care electronic medical records database in Catalonia from 2011 to 2015 aimed to identify the use of TT in patients with newly diagnosed COPD. A total of 69,668 newly diagnosed patients were identified of whom 11,524 (16.5%) initiated TT, of whom 8626 initiated TT at or immediately after COPD diagnosis. Among them, 72.3% were GOLD A/B, 14.6% were frequent exacerbators, and 7.1% had asthma–COPD overlap (ACO). Variables associated with TT initiation were: male sex, older age, previous exacerbations, ACO, a previous treatment regimen containing an inhaled corticosteroid, previous pneumonia, and history of lung cancer. A significant number of COPD patients in Primary Care initiated TT shortly after or even before an established COPD diagnosis.
format	article
author	Mònica Monteagudo Miriam Barrecheguren Iryna Solntseva Nafeesa Dhalwani Alison Booth Alexa Nuñez Dimitra Lambrelli Marc Miravitlles
author_facet	Mònica Monteagudo Miriam Barrecheguren Iryna Solntseva Nafeesa Dhalwani Alison Booth Alexa Nuñez Dimitra Lambrelli Marc Miravitlles
author_sort	Mònica Monteagudo
title	Clinical characteristics and factors associated with triple therapy use in newly diagnosed patients with COPD
title_short	Clinical characteristics and factors associated with triple therapy use in newly diagnosed patients with COPD
title_full	Clinical characteristics and factors associated with triple therapy use in newly diagnosed patients with COPD
title_fullStr	Clinical characteristics and factors associated with triple therapy use in newly diagnosed patients with COPD
title_full_unstemmed	Clinical characteristics and factors associated with triple therapy use in newly diagnosed patients with COPD
title_sort	clinical characteristics and factors associated with triple therapy use in newly diagnosed patients with copd
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/53f3eceade6c4e54a4020da3b4fd6f5a
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Clinical characteristics and factors associated with triple therapy use in newly diagnosed patients with COPD

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