Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery

Qi Tan1, Weidong Liu1,2, Chenyu Guo1, Guangxi Zhai11Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan; 2Department of Pharmacy, Linyi People&#39;s Hospital Affiliated to Shandong University, Linyi, People&#39;s Republic of ChinaBackground: The purpose of th...

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Autores principales:	Tan Q, Liu WD, Guo CY, Zhai GX
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/53f6078eb8d8464b8215eaa01c1ea273
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spelling	oai:doaj.org-article:53f6078eb8d8464b8215eaa01c1ea2732021-12-02T02:28:08ZPreparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery1176-91141178-2013https://doaj.org/article/53f6078eb8d8464b8215eaa01c1ea2732011-08-01T00:00:00Zhttp://www.dovepress.com/preparation-and-evaluation-of-quercetin-loaded-lecithin-chitosan-nanop-a8054https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Qi Tan1, Weidong Liu1,2, Chenyu Guo1, Guangxi Zhai11Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan; 2Department of Pharmacy, Linyi People&#39;s Hospital Affiliated to Shandong University, Linyi, People&#39;s Republic of ChinaBackground: The purpose of this study was to investigate lecithin-chitosan nanoparticles as a topical delivery system for quercetin.Methods: Tocopheryl propylene glycol succinate was chosen to be the surfactant for the nanosystem. The mean particle size of the nanoparticles was 95.3 nm, and the entrapment efficiency and drug loading for quercetin were 48.5% and 2.45%, respectively. Topical delivery in vitro and in vivo of the quercetin-loaded nanoparticles was evaluated using quercetin propylene glycol solution as the control.Results: Compared with quercetin solution, the quercetin-loaded nanoparticles showed higher permeation ability, and significantly increased accumulation of quercetin in the skin, especially in the epidermis. Microstructure observation of the skin surface after administration indicated that the interaction between ingredients of the nanoparticles and the skin surface markedly changed the morphology of the stratum corneum and disrupted the corneocyte layers, thus facilitating the permeation and accumulation of quercetin in skin.Conclusion: Lecithin-chitosan nanoparticles are a promising carrier for topical delivery of quercetin.Keywords: quercetin, tocopheryl polyethylene glycol succinate, lecithin, chitosan, nanoparticles, topical deliveryTan QLiu WDGuo CYZhai GXDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 1621-1630 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Tan Q Liu WD Guo CY Zhai GX Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery
description	Qi Tan1, Weidong Liu1,2, Chenyu Guo1, Guangxi Zhai11Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan; 2Department of Pharmacy, Linyi People&#39;s Hospital Affiliated to Shandong University, Linyi, People&#39;s Republic of ChinaBackground: The purpose of this study was to investigate lecithin-chitosan nanoparticles as a topical delivery system for quercetin.Methods: Tocopheryl propylene glycol succinate was chosen to be the surfactant for the nanosystem. The mean particle size of the nanoparticles was 95.3 nm, and the entrapment efficiency and drug loading for quercetin were 48.5% and 2.45%, respectively. Topical delivery in vitro and in vivo of the quercetin-loaded nanoparticles was evaluated using quercetin propylene glycol solution as the control.Results: Compared with quercetin solution, the quercetin-loaded nanoparticles showed higher permeation ability, and significantly increased accumulation of quercetin in the skin, especially in the epidermis. Microstructure observation of the skin surface after administration indicated that the interaction between ingredients of the nanoparticles and the skin surface markedly changed the morphology of the stratum corneum and disrupted the corneocyte layers, thus facilitating the permeation and accumulation of quercetin in skin.Conclusion: Lecithin-chitosan nanoparticles are a promising carrier for topical delivery of quercetin.Keywords: quercetin, tocopheryl polyethylene glycol succinate, lecithin, chitosan, nanoparticles, topical delivery
format	article
author	Tan Q Liu WD Guo CY Zhai GX
author_facet	Tan Q Liu WD Guo CY Zhai GX
author_sort	Tan Q
title	Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery
title_short	Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery
title_full	Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery
title_fullStr	Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery
title_full_unstemmed	Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery
title_sort	preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/53f6078eb8d8464b8215eaa01c1ea273
work_keys_str_mv	AT tanq preparationandevaluationofquercetinloadedlecithinchitosannanoparticlesfortopicaldelivery AT liuwd preparationandevaluationofquercetinloadedlecithinchitosannanoparticlesfortopicaldelivery AT guocy preparationandevaluationofquercetinloadedlecithinchitosannanoparticlesfortopicaldelivery AT zhaigx preparationandevaluationofquercetinloadedlecithinchitosannanoparticlesfortopicaldelivery
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Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery

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