Aortic Stiffness: Epidemiology, Risk Factors, and Relevant Biomarkers

Aortic stiffness (AoS) is a maladaptive response to hemodynamic stress and both modifiable and non-modifiable risk factors, and elevated AoS increases afterload for the heart. AoS is a non-invasive marker of cardiovascular health and metabolic dysfunction. Implementing AoS as a diagnostic tool is ch...

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Autores principales:	Rebecca Angoff, Ramya C. Mosarla, Connie W. Tsao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	aortic stiffness pulse wave velocity cardiovascular health risk factors biomarkers Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/53f6e25be87b48b3b43302dd683e7a9d
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spelling	oai:doaj.org-article:53f6e25be87b48b3b43302dd683e7a9d2021-11-08T06:29:21ZAortic Stiffness: Epidemiology, Risk Factors, and Relevant Biomarkers2297-055X10.3389/fcvm.2021.709396https://doaj.org/article/53f6e25be87b48b3b43302dd683e7a9d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.709396/fullhttps://doaj.org/toc/2297-055XAortic stiffness (AoS) is a maladaptive response to hemodynamic stress and both modifiable and non-modifiable risk factors, and elevated AoS increases afterload for the heart. AoS is a non-invasive marker of cardiovascular health and metabolic dysfunction. Implementing AoS as a diagnostic tool is challenging as it increases with age and varies amongst races. AoS is associated with lifestyle factors such as alcohol and smoking, as well as hypertension and comorbid conditions including metabolic syndrome and its components. Multiple studies have investigated various biomarkers associated with increased AoS, and this area is of particular interest given that these markers can highlight pathophysiologic pathways and specific therapeutic targets in the future. These biomarkers include those involved in the inflammatory cascade, anti-aging genes, and the renin-angiotensin aldosterone system. In the future, targeting AoS rather than blood pressure itself may be the key to improving vascular health and outcomes. In this review, we will discuss the current understanding of AoS, measurement of AoS and the challenges in interpretation, associated biomarkers, and possible therapeutic avenues for modulation of AoS.Rebecca AngoffRamya C. MosarlaConnie W. TsaoFrontiers Media S.A.articleaortic stiffnesspulse wave velocitycardiovascular healthrisk factorsbiomarkersDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aortic stiffness pulse wave velocity cardiovascular health risk factors biomarkers Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	aortic stiffness pulse wave velocity cardiovascular health risk factors biomarkers Diseases of the circulatory (Cardiovascular) system RC666-701 Rebecca Angoff Ramya C. Mosarla Connie W. Tsao Aortic Stiffness: Epidemiology, Risk Factors, and Relevant Biomarkers
description	Aortic stiffness (AoS) is a maladaptive response to hemodynamic stress and both modifiable and non-modifiable risk factors, and elevated AoS increases afterload for the heart. AoS is a non-invasive marker of cardiovascular health and metabolic dysfunction. Implementing AoS as a diagnostic tool is challenging as it increases with age and varies amongst races. AoS is associated with lifestyle factors such as alcohol and smoking, as well as hypertension and comorbid conditions including metabolic syndrome and its components. Multiple studies have investigated various biomarkers associated with increased AoS, and this area is of particular interest given that these markers can highlight pathophysiologic pathways and specific therapeutic targets in the future. These biomarkers include those involved in the inflammatory cascade, anti-aging genes, and the renin-angiotensin aldosterone system. In the future, targeting AoS rather than blood pressure itself may be the key to improving vascular health and outcomes. In this review, we will discuss the current understanding of AoS, measurement of AoS and the challenges in interpretation, associated biomarkers, and possible therapeutic avenues for modulation of AoS.
format	article
author	Rebecca Angoff Ramya C. Mosarla Connie W. Tsao
author_facet	Rebecca Angoff Ramya C. Mosarla Connie W. Tsao
author_sort	Rebecca Angoff
title	Aortic Stiffness: Epidemiology, Risk Factors, and Relevant Biomarkers
title_short	Aortic Stiffness: Epidemiology, Risk Factors, and Relevant Biomarkers
title_full	Aortic Stiffness: Epidemiology, Risk Factors, and Relevant Biomarkers
title_fullStr	Aortic Stiffness: Epidemiology, Risk Factors, and Relevant Biomarkers
title_full_unstemmed	Aortic Stiffness: Epidemiology, Risk Factors, and Relevant Biomarkers
title_sort	aortic stiffness: epidemiology, risk factors, and relevant biomarkers
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/53f6e25be87b48b3b43302dd683e7a9d
work_keys_str_mv	AT rebeccaangoff aorticstiffnessepidemiologyriskfactorsandrelevantbiomarkers AT ramyacmosarla aorticstiffnessepidemiologyriskfactorsandrelevantbiomarkers AT conniewtsao aorticstiffnessepidemiologyriskfactorsandrelevantbiomarkers
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Aortic Stiffness: Epidemiology, Risk Factors, and Relevant Biomarkers

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