Efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysis

Abstract Taxanes are chemotherapeutic agents commonly used to treat several cancers. However, the effects of taxanes on advanced gastric cancer (AGC) are still not clear, especially when used as a first-line treatment. This systematic review and meta-analysis aims to investigate the efficacy and saf...

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Autores principales:	Jinxin Shi, Peng Gao, Yongxi Song, Xiaowan Chen, Yuan Li, Changwang Zhang, Hongchi Wang, Zhenning Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/53f8d5fc975a404cb5f89ca423feb58b
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spelling	oai:doaj.org-article:53f8d5fc975a404cb5f89ca423feb58b2021-12-02T16:06:19ZEfficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysis10.1038/s41598-017-05464-02045-2322https://doaj.org/article/53f8d5fc975a404cb5f89ca423feb58b2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05464-0https://doaj.org/toc/2045-2322Abstract Taxanes are chemotherapeutic agents commonly used to treat several cancers. However, the effects of taxanes on advanced gastric cancer (AGC) are still not clear, especially when used as a first-line treatment. This systematic review and meta-analysis aims to investigate the efficacy and safety of taxanes as a first-line treatment of AGC. The quality of our included studies was assessed using the Cochrane risk of bias tool for RCTs and NOS scale for nRCTs, and the data of the included studies was of satisfactory quality to analyze. The outcomes included overall survival (OS), progression-free survival (PFS), overall response rate (ORR), and toxicity. Taxanes significantly improved OS (HR = 0.84, 95% CI 0.76–0.92, P = 0.0004) and had a slight effect on ORR (RR = 1.23, 95% CI 1.00–1.51, P = 0.05). However, taxanes may also increase the risks of neutropenia and leucopenia, similar to effects observed in other conventional chemotherapeutic treatments such as oxaliplatin and epirubicin. Therefore, patient characteristics including concomitant diseases, physical condition, and prior therapies should be considered before selecting taxane-based treatments for AGC.Jinxin ShiPeng GaoYongxi SongXiaowan ChenYuan LiChangwang ZhangHongchi WangZhenning WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jinxin Shi Peng Gao Yongxi Song Xiaowan Chen Yuan Li Changwang Zhang Hongchi Wang Zhenning Wang Efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysis
description	Abstract Taxanes are chemotherapeutic agents commonly used to treat several cancers. However, the effects of taxanes on advanced gastric cancer (AGC) are still not clear, especially when used as a first-line treatment. This systematic review and meta-analysis aims to investigate the efficacy and safety of taxanes as a first-line treatment of AGC. The quality of our included studies was assessed using the Cochrane risk of bias tool for RCTs and NOS scale for nRCTs, and the data of the included studies was of satisfactory quality to analyze. The outcomes included overall survival (OS), progression-free survival (PFS), overall response rate (ORR), and toxicity. Taxanes significantly improved OS (HR = 0.84, 95% CI 0.76–0.92, P = 0.0004) and had a slight effect on ORR (RR = 1.23, 95% CI 1.00–1.51, P = 0.05). However, taxanes may also increase the risks of neutropenia and leucopenia, similar to effects observed in other conventional chemotherapeutic treatments such as oxaliplatin and epirubicin. Therefore, patient characteristics including concomitant diseases, physical condition, and prior therapies should be considered before selecting taxane-based treatments for AGC.
format	article
author	Jinxin Shi Peng Gao Yongxi Song Xiaowan Chen Yuan Li Changwang Zhang Hongchi Wang Zhenning Wang
author_facet	Jinxin Shi Peng Gao Yongxi Song Xiaowan Chen Yuan Li Changwang Zhang Hongchi Wang Zhenning Wang
author_sort	Jinxin Shi
title	Efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysis
title_short	Efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysis
title_full	Efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysis
title_fullStr	Efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysis
title_full_unstemmed	Efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysis
title_sort	efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: a systematic review and meta-analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/53f8d5fc975a404cb5f89ca423feb58b
work_keys_str_mv	AT jinxinshi efficacyandsafetyoftaxanebasedsystemicchemotherapyofadvancedgastriccancerasystematicreviewandmetaanalysis AT penggao efficacyandsafetyoftaxanebasedsystemicchemotherapyofadvancedgastriccancerasystematicreviewandmetaanalysis AT yongxisong efficacyandsafetyoftaxanebasedsystemicchemotherapyofadvancedgastriccancerasystematicreviewandmetaanalysis AT xiaowanchen efficacyandsafetyoftaxanebasedsystemicchemotherapyofadvancedgastriccancerasystematicreviewandmetaanalysis AT yuanli efficacyandsafetyoftaxanebasedsystemicchemotherapyofadvancedgastriccancerasystematicreviewandmetaanalysis AT changwangzhang efficacyandsafetyoftaxanebasedsystemicchemotherapyofadvancedgastriccancerasystematicreviewandmetaanalysis AT hongchiwang efficacyandsafetyoftaxanebasedsystemicchemotherapyofadvancedgastriccancerasystematicreviewandmetaanalysis AT zhenningwang efficacyandsafetyoftaxanebasedsystemicchemotherapyofadvancedgastriccancerasystematicreviewandmetaanalysis
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Efficacy and safety of taxane-based systemic chemotherapy of advanced gastric cancer: A systematic review and meta-analysis

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