Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons

Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons

Rab3-interacting molecules (RIMs) are a key component of the presynaptic active zone that regulate neurotransmitter release. Here, the authors show that RIM1 also has postsynaptic function to organize NMDA receptors and synaptic response.

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Autores principales: Jiejie Wang, Xinyou Lv, Yu Wu, Tao Xu, Mingfei Jiao, Risheng Yang, Xia Li, Ming Chen, Yinggang Yan, Changwan Chen, Weifan Dong, Wei Yang, Min Zhuo, Tao Chen, Jianhong Luo, Shuang Qiu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/53f95c46d3ad4568a76275b5b8ee1546
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spelling oai:doaj.org-article:53f95c46d3ad4568a76275b5b8ee15462021-12-02T16:49:51ZPostsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons10.1038/s41467-018-04672-02041-1723https://doaj.org/article/53f95c46d3ad4568a76275b5b8ee15462018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04672-0https://doaj.org/toc/2041-1723Rab3-interacting molecules (RIMs) are a key component of the presynaptic active zone that regulate neurotransmitter release. Here, the authors show that RIM1 also has postsynaptic function to organize NMDA receptors and synaptic response.Jiejie WangXinyou LvYu WuTao XuMingfei JiaoRisheng YangXia LiMing ChenYinggang YanChangwan ChenWeifan DongWei YangMin ZhuoTao ChenJianhong LuoShuang QiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jiejie Wang
Xinyou Lv
Yu Wu
Tao Xu
Mingfei Jiao
Risheng Yang
Xia Li
Ming Chen
Yinggang Yan
Changwan Chen
Weifan Dong
Wei Yang
Min Zhuo
Tao Chen
Jianhong Luo
Shuang Qiu
Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons
description Rab3-interacting molecules (RIMs) are a key component of the presynaptic active zone that regulate neurotransmitter release. Here, the authors show that RIM1 also has postsynaptic function to organize NMDA receptors and synaptic response.
format article
author Jiejie Wang
Xinyou Lv
Yu Wu
Tao Xu
Mingfei Jiao
Risheng Yang
Xia Li
Ming Chen
Yinggang Yan
Changwan Chen
Weifan Dong
Wei Yang
Min Zhuo
Tao Chen
Jianhong Luo
Shuang Qiu
author_facet Jiejie Wang
Xinyou Lv
Yu Wu
Tao Xu
Mingfei Jiao
Risheng Yang
Xia Li
Ming Chen
Yinggang Yan
Changwan Chen
Weifan Dong
Wei Yang
Min Zhuo
Tao Chen
Jianhong Luo
Shuang Qiu
author_sort Jiejie Wang
title Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons
title_short Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons
title_full Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons
title_fullStr Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons
title_full_unstemmed Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons
title_sort postsynaptic rim1 modulates synaptic function by facilitating membrane delivery of recycling nmdars in hippocampal neurons
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/53f95c46d3ad4568a76275b5b8ee1546
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