Evaluation of Prognosis and Risk of Death by Neutrophil/Lymphocyte Ratio, C-Reactive Protein/Albumin Ratio and Plasma D-Dimer in Patients with Pulmonary Thromboembolism
Tiantian Shan,* Xinran Li,* Min Yan, Xiangtao Pan Department of Hematology, Taicang Hospital Affiliated to Soochow University, Taicang City, Jiangsu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiangtao Pan Tel +86 1891576...
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Dove Medical Press
2021
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oai:doaj.org-article:53f98a2d858c4ca8920bdc4c3e026d852021-12-02T19:17:36ZEvaluation of Prognosis and Risk of Death by Neutrophil/Lymphocyte Ratio, C-Reactive Protein/Albumin Ratio and Plasma D-Dimer in Patients with Pulmonary Thromboembolism1178-7074https://doaj.org/article/53f98a2d858c4ca8920bdc4c3e026d852021-12-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-prognosis-and-risk-of-death-by-neutrophillymphocyte-rati-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Tiantian Shan,* Xinran Li,* Min Yan, Xiangtao Pan Department of Hematology, Taicang Hospital Affiliated to Soochow University, Taicang City, Jiangsu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiangtao Pan Tel +86 18915768003Email drpanxiangtao@163.comObjective: To investigate the relationship between neutrophil/lymphocyte ratio, C-reactive protein/albumin ratio, plasma D-dimer and prognosis in patients with pulmonary thromboembolism, and to evaluate the risk of death.Methods: We retrospectively analyzed peripheral hematology and coagulation-related indicators of 362 pulmonary thromboembolism patients and 32 normal people, and the differences between the patients and control group and between good and poor prognosis groups were compared. And we analyzed and compared separate detection and combined detection of neutrophil/lymphocyte ratio, C-reactive protein/albumin ratio and D-dimer on the efficiency of risk of death in patients.Results: ① Neutrophil/lymphocyte ratio of pulmonary thromboembolism patients was 8.96± 1.94, significantly higher than that of control group 1.76± 0.53 (t=2.4281, P< 0.05). C-reactive protein/albumin ratio was 2.13± 2.08, significantly higher than 0.03± 0.01 in control group (t=20.7736, P< 0.01). D-dimer was 9.69± 8.61mg/L, significantly higher than 0.20± 0.11mg/L in control group (t=3.0066, P< 0.01). ② Hemoglobin, lymphocyte, albumin and lymphocyte/monocyte ratio in patients with good prognosis were significantly lower than those in poor prognosis group, while white blood cell, C-creative protein, neutrophil, C-reactive protein/albumin ratio, neutrophil/lymphocyte ratio and D-dimer were significantly lower than those in poor prognosis group (P all < 0.05). ③ Regression analysis showed that neutrophil/lymphocyte ratio (P=0.007), C-reactive protein/albumin ratio (P=0.010) and D-dimer (P=0.003) were independent prognostic factors for pulmonary thromboembolism. ④ In assessing the risk of death of patients, D-dimer alone had the highest sensitivity (93.1%), and C-reactive protein/albumin ratio alone had the highest specificity (68.8%). The combined detection of these three indicators had higher sensitivity (86.2%) and higher specificity (67.6%) at the same time. ⑤ The area under receiver operating characteristic curve for combined detection of neutrophil/lymphocyte ratio, C-reactive protein/albumin ratio and D-dimer was the largest (up to 0.821).Conclusion: Patients with pulmonary thromboembolism highly expressed in neutrophil/lymphocyte ratio, C-reactive protein/albumin ratio and D-dimer. The combined detection of these three indicators can improve the assessment efficacy of the risk of death in patients with pulmonary thromboembolism.Keywords: pulmonary thromboembolism, neutrophil to lymphocyte ratio, C-reactive protein/albumin ratio, plasma D-dimer, risk assessment of death, prognosisShan TLi XYan MPan XDove Medical Pressarticlepulmonary thromboembolismneutrophil to lymphocyte ratioc-reactive protein/albumin ratioplasma d-dimerrisk assessment of deathprognosisMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 9219-9225 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
pulmonary thromboembolism neutrophil to lymphocyte ratio c-reactive protein/albumin ratio plasma d-dimer risk assessment of death prognosis Medicine (General) R5-920 |
| spellingShingle |
pulmonary thromboembolism neutrophil to lymphocyte ratio c-reactive protein/albumin ratio plasma d-dimer risk assessment of death prognosis Medicine (General) R5-920 Shan T Li X Yan M Pan X Evaluation of Prognosis and Risk of Death by Neutrophil/Lymphocyte Ratio, C-Reactive Protein/Albumin Ratio and Plasma D-Dimer in Patients with Pulmonary Thromboembolism |
| description |
Tiantian Shan,* Xinran Li,* Min Yan, Xiangtao Pan Department of Hematology, Taicang Hospital Affiliated to Soochow University, Taicang City, Jiangsu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiangtao Pan Tel +86 18915768003Email drpanxiangtao@163.comObjective: To investigate the relationship between neutrophil/lymphocyte ratio, C-reactive protein/albumin ratio, plasma D-dimer and prognosis in patients with pulmonary thromboembolism, and to evaluate the risk of death.Methods: We retrospectively analyzed peripheral hematology and coagulation-related indicators of 362 pulmonary thromboembolism patients and 32 normal people, and the differences between the patients and control group and between good and poor prognosis groups were compared. And we analyzed and compared separate detection and combined detection of neutrophil/lymphocyte ratio, C-reactive protein/albumin ratio and D-dimer on the efficiency of risk of death in patients.Results: ① Neutrophil/lymphocyte ratio of pulmonary thromboembolism patients was 8.96± 1.94, significantly higher than that of control group 1.76± 0.53 (t=2.4281, P< 0.05). C-reactive protein/albumin ratio was 2.13± 2.08, significantly higher than 0.03± 0.01 in control group (t=20.7736, P< 0.01). D-dimer was 9.69± 8.61mg/L, significantly higher than 0.20± 0.11mg/L in control group (t=3.0066, P< 0.01). ② Hemoglobin, lymphocyte, albumin and lymphocyte/monocyte ratio in patients with good prognosis were significantly lower than those in poor prognosis group, while white blood cell, C-creative protein, neutrophil, C-reactive protein/albumin ratio, neutrophil/lymphocyte ratio and D-dimer were significantly lower than those in poor prognosis group (P all < 0.05). ③ Regression analysis showed that neutrophil/lymphocyte ratio (P=0.007), C-reactive protein/albumin ratio (P=0.010) and D-dimer (P=0.003) were independent prognostic factors for pulmonary thromboembolism. ④ In assessing the risk of death of patients, D-dimer alone had the highest sensitivity (93.1%), and C-reactive protein/albumin ratio alone had the highest specificity (68.8%). The combined detection of these three indicators had higher sensitivity (86.2%) and higher specificity (67.6%) at the same time. ⑤ The area under receiver operating characteristic curve for combined detection of neutrophil/lymphocyte ratio, C-reactive protein/albumin ratio and D-dimer was the largest (up to 0.821).Conclusion: Patients with pulmonary thromboembolism highly expressed in neutrophil/lymphocyte ratio, C-reactive protein/albumin ratio and D-dimer. The combined detection of these three indicators can improve the assessment efficacy of the risk of death in patients with pulmonary thromboembolism.Keywords: pulmonary thromboembolism, neutrophil to lymphocyte ratio, C-reactive protein/albumin ratio, plasma D-dimer, risk assessment of death, prognosis |
| format |
article |
| author |
Shan T Li X Yan M Pan X |
| author_facet |
Shan T Li X Yan M Pan X |
| author_sort |
Shan T |
| title |
Evaluation of Prognosis and Risk of Death by Neutrophil/Lymphocyte Ratio, C-Reactive Protein/Albumin Ratio and Plasma D-Dimer in Patients with Pulmonary Thromboembolism |
| title_short |
Evaluation of Prognosis and Risk of Death by Neutrophil/Lymphocyte Ratio, C-Reactive Protein/Albumin Ratio and Plasma D-Dimer in Patients with Pulmonary Thromboembolism |
| title_full |
Evaluation of Prognosis and Risk of Death by Neutrophil/Lymphocyte Ratio, C-Reactive Protein/Albumin Ratio and Plasma D-Dimer in Patients with Pulmonary Thromboembolism |
| title_fullStr |
Evaluation of Prognosis and Risk of Death by Neutrophil/Lymphocyte Ratio, C-Reactive Protein/Albumin Ratio and Plasma D-Dimer in Patients with Pulmonary Thromboembolism |
| title_full_unstemmed |
Evaluation of Prognosis and Risk of Death by Neutrophil/Lymphocyte Ratio, C-Reactive Protein/Albumin Ratio and Plasma D-Dimer in Patients with Pulmonary Thromboembolism |
| title_sort |
evaluation of prognosis and risk of death by neutrophil/lymphocyte ratio, c-reactive protein/albumin ratio and plasma d-dimer in patients with pulmonary thromboembolism |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/53f98a2d858c4ca8920bdc4c3e026d85 |
| work_keys_str_mv |
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