Real time in-vivo miniature endoscopic surveillance system for imaging of nasopharynx

Objective: To test the feasibility of a real time miniature endoscope system for imaging the nasopharynx. Study design: Preclinical assessment on skull model and cadaver. Methods: A 3.5 mm miniature endoscope was fabricated and the image capture of the nasopharynx was investigated by positioning the...

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Autores principales:	Chwee Ming Lim, Gangodu Nagaraja Rao, Hongliang Ren
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2020
Materias:	Nasopharyngeal carcinoma In vivo miniature endoscope Imaging Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/53fae96f86184a6e8bd03f8be820f337
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spelling	oai:doaj.org-article:53fae96f86184a6e8bd03f8be820f3372021-12-02T17:35:06ZReal time in-vivo miniature endoscopic surveillance system for imaging of nasopharynx2095-881110.1016/j.wjorl.2020.02.004https://doaj.org/article/53fae96f86184a6e8bd03f8be820f3372020-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881120300251https://doaj.org/toc/2095-8811Objective: To test the feasibility of a real time miniature endoscope system for imaging the nasopharynx. Study design: Preclinical assessment on skull model and cadaver. Methods: A 3.5 mm miniature endoscope was fabricated and the image capture of the nasopharynx was investigated by positioning the miniature camera system at the posterior free edge of the vomer bone. Wireless real time transmission of the images and quality was tested in a skull model. Next, three nasopharyngeal surveillance miniature camera system were developed for possible clinical translation. Two prototypes were anchored on the nasal septum and the last prototype was designed using a patient self-administered surveillance process. These prototypes were tested for feasibility on both the phantom skull and cadaveric model. Risk assessments were also performed to assess risk, safety and validate the reliability of the material utilized for clinical translation. Results: Insertion and anchorage of the miniature surveillance endoscope prototypes at the vomer bone were feasible on all 3 prototypes. The quality of captured images was reasonable and miniaturized camera was responsive to pan at different angles so that the entire nasopharynx may be surveyed. Risk assessments on the material such as pull out test, breaking force analysis, finite element test and tensile strength test were reliable for possible clinical translation. Conclusions: Real time miniature endoscope system for surveillance of nasopharyngeal cancer is feasible. Clinical translation of this technology was possible but requires further refinement in enhancing image quality and wireless transmission of the captured images.Chwee Ming LimGangodu Nagaraja RaoHongliang RenKeAi Communications Co., Ltd.articleNasopharyngeal carcinomaIn vivo miniature endoscopeImagingOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 6, Iss 1, Pp 4-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nasopharyngeal carcinoma In vivo miniature endoscope Imaging Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Nasopharyngeal carcinoma In vivo miniature endoscope Imaging Otorhinolaryngology RF1-547 Surgery RD1-811 Chwee Ming Lim Gangodu Nagaraja Rao Hongliang Ren Real time in-vivo miniature endoscopic surveillance system for imaging of nasopharynx
description	Objective: To test the feasibility of a real time miniature endoscope system for imaging the nasopharynx. Study design: Preclinical assessment on skull model and cadaver. Methods: A 3.5 mm miniature endoscope was fabricated and the image capture of the nasopharynx was investigated by positioning the miniature camera system at the posterior free edge of the vomer bone. Wireless real time transmission of the images and quality was tested in a skull model. Next, three nasopharyngeal surveillance miniature camera system were developed for possible clinical translation. Two prototypes were anchored on the nasal septum and the last prototype was designed using a patient self-administered surveillance process. These prototypes were tested for feasibility on both the phantom skull and cadaveric model. Risk assessments were also performed to assess risk, safety and validate the reliability of the material utilized for clinical translation. Results: Insertion and anchorage of the miniature surveillance endoscope prototypes at the vomer bone were feasible on all 3 prototypes. The quality of captured images was reasonable and miniaturized camera was responsive to pan at different angles so that the entire nasopharynx may be surveyed. Risk assessments on the material such as pull out test, breaking force analysis, finite element test and tensile strength test were reliable for possible clinical translation. Conclusions: Real time miniature endoscope system for surveillance of nasopharyngeal cancer is feasible. Clinical translation of this technology was possible but requires further refinement in enhancing image quality and wireless transmission of the captured images.
format	article
author	Chwee Ming Lim Gangodu Nagaraja Rao Hongliang Ren
author_facet	Chwee Ming Lim Gangodu Nagaraja Rao Hongliang Ren
author_sort	Chwee Ming Lim
title	Real time in-vivo miniature endoscopic surveillance system for imaging of nasopharynx
title_short	Real time in-vivo miniature endoscopic surveillance system for imaging of nasopharynx
title_full	Real time in-vivo miniature endoscopic surveillance system for imaging of nasopharynx
title_fullStr	Real time in-vivo miniature endoscopic surveillance system for imaging of nasopharynx
title_full_unstemmed	Real time in-vivo miniature endoscopic surveillance system for imaging of nasopharynx
title_sort	real time in-vivo miniature endoscopic surveillance system for imaging of nasopharynx
publisher	KeAi Communications Co., Ltd.
publishDate	2020
url	https://doaj.org/article/53fae96f86184a6e8bd03f8be820f337
work_keys_str_mv	AT chweeminglim realtimeinvivominiatureendoscopicsurveillancesystemforimagingofnasopharynx AT gangodunagarajarao realtimeinvivominiatureendoscopicsurveillancesystemforimagingofnasopharynx AT hongliangren realtimeinvivominiatureendoscopicsurveillancesystemforimagingofnasopharynx
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Real time in-vivo miniature endoscopic surveillance system for imaging of nasopharynx

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