Molecular architecture of a cylindrical self-assembly at human centrosomes

Molecular architecture of a cylindrical self-assembly at human centrosomes

The centrosome is a membraneless organelle composed of two centrioles and an amorphous pericentriolar material but the overall centrosome organizations remains unknown. Here authors show that two scaffold proteins, Cep63 and Cep152, self-assemble into a higher-order cylindrical architecture capable...

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Autores principales: Tae-Sung Kim, Liang Zhang, Jong Il Ahn, Lingjun Meng, Yang Chen, Eunhye Lee, Jeong Kyu Bang, Jung Mi Lim, Rodolfo Ghirlando, Lixin Fan, Yun-Xing Wang, Bo Yeon Kim, Jung-Eun Park, Kyung S. Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/5400f07be0494a47a4919ee1084eef02
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spelling oai:doaj.org-article:5400f07be0494a47a4919ee1084eef022021-12-02T16:57:11ZMolecular architecture of a cylindrical self-assembly at human centrosomes10.1038/s41467-019-08838-22041-1723https://doaj.org/article/5400f07be0494a47a4919ee1084eef022019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08838-2https://doaj.org/toc/2041-1723The centrosome is a membraneless organelle composed of two centrioles and an amorphous pericentriolar material but the overall centrosome organizations remains unknown. Here authors show that two scaffold proteins, Cep63 and Cep152, self-assemble into a higher-order cylindrical architecture capable of recruiting downstream components, including Plk4.Tae-Sung KimLiang ZhangJong Il AhnLingjun MengYang ChenEunhye LeeJeong Kyu BangJung Mi LimRodolfo GhirlandoLixin FanYun-Xing WangBo Yeon KimJung-Eun ParkKyung S. LeeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tae-Sung Kim
Liang Zhang
Jong Il Ahn
Lingjun Meng
Yang Chen
Eunhye Lee
Jeong Kyu Bang
Jung Mi Lim
Rodolfo Ghirlando
Lixin Fan
Yun-Xing Wang
Bo Yeon Kim
Jung-Eun Park
Kyung S. Lee
Molecular architecture of a cylindrical self-assembly at human centrosomes
description The centrosome is a membraneless organelle composed of two centrioles and an amorphous pericentriolar material but the overall centrosome organizations remains unknown. Here authors show that two scaffold proteins, Cep63 and Cep152, self-assemble into a higher-order cylindrical architecture capable of recruiting downstream components, including Plk4.
format article
author Tae-Sung Kim
Liang Zhang
Jong Il Ahn
Lingjun Meng
Yang Chen
Eunhye Lee
Jeong Kyu Bang
Jung Mi Lim
Rodolfo Ghirlando
Lixin Fan
Yun-Xing Wang
Bo Yeon Kim
Jung-Eun Park
Kyung S. Lee
author_facet Tae-Sung Kim
Liang Zhang
Jong Il Ahn
Lingjun Meng
Yang Chen
Eunhye Lee
Jeong Kyu Bang
Jung Mi Lim
Rodolfo Ghirlando
Lixin Fan
Yun-Xing Wang
Bo Yeon Kim
Jung-Eun Park
Kyung S. Lee
author_sort Tae-Sung Kim
title Molecular architecture of a cylindrical self-assembly at human centrosomes
title_short Molecular architecture of a cylindrical self-assembly at human centrosomes
title_full Molecular architecture of a cylindrical self-assembly at human centrosomes
title_fullStr Molecular architecture of a cylindrical self-assembly at human centrosomes
title_full_unstemmed Molecular architecture of a cylindrical self-assembly at human centrosomes
title_sort molecular architecture of a cylindrical self-assembly at human centrosomes
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/5400f07be0494a47a4919ee1084eef02
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AT jongilahn moleculararchitectureofacylindricalselfassemblyathumancentrosomes
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AT yangchen moleculararchitectureofacylindricalselfassemblyathumancentrosomes
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