Korsakoff’s syndrome: a critical review

Korsakoff’s syndrome: a critical review

Nicolaas JM Arts,1,2 Serge JW Walvoort,1 Roy PC Kessels1,3,4 1Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, 2Neuropsychiatry Center Thalamus, Institution for Integrated Mental Health Care Pro Persona, Wolfheze, 3Depart...

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Autores principales: Arts NJM, Walvoort SJW, Kessels RPC
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
Korsakoff’s Syndrome
Alcohol Amnestic Disorder
Wernicke Encephalopathy
Thiamine Deficiency
Ethanol Neurotoxicity
Thalamus
Memory
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/540152734c164b6da3a406552b46fe22
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spelling oai:doaj.org-article:540152734c164b6da3a406552b46fe222021-12-02T00:37:41ZKorsakoff’s syndrome: a critical review1178-2021https://doaj.org/article/540152734c164b6da3a406552b46fe222017-11-01T00:00:00Zhttps://www.dovepress.com/korsakoffs-syndrome-a-critical-review-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Nicolaas JM Arts,1,2 Serge JW Walvoort,1 Roy PC Kessels1,3,4 1Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, 2Neuropsychiatry Center Thalamus, Institution for Integrated Mental Health Care Pro Persona, Wolfheze, 3Department of Neuropsychology and Rehabilitation Psychology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, 4Department of Medical Psychology, Radboud University Medical Center, Nijmegen, the Netherlands Abstract: In this review, we present a survey on Korsakoff’s syndrome (KS), a residual syndrome in patients who suffered from a Wernicke encephalopathy (WE) that is predominantly characterized by global amnesia, and in more severe cases also by cognitive and behavioral dysfunction. We describe the history of KS and its definition, its epidemiology, and the lack of consensus criteria for its diagnosis. The cognitive and behavioral symptoms of KS, which include anterograde and retrograde amnesia, executive dysfunction, confabulation, apathy, as well as affective and social-cognitive impairments, are discussed. Moreover, recent insights into the underlying neurocognitive mechanisms of these symptoms are presented. In addition, the evidence so far on the etiology of KS is examined, highlighting the role of thiamine and alcohol and discussing the continuity hypothesis. Furthermore, the neuropathology of KS is reviewed, focusing on abnormalities in the diencephalon, including the mammillary bodies and thalamic nuclei. Pharmacological treatment options and nonpharmacological interventions, such as those based on cognitive rehabilitation, are discussed. Our review shows that thiamine deficiency (TD) is a crucial factor in the etiology of KS. Although alcohol abuse is by far the most important context in which TD occurs, there is no convincing evidence for an essential contribution of ethanol neurotoxicity (EN) to the development of WE or to the progression of WE to KS. Future research on the postmortem histopathological analysis of brain tissues of KS patients is crucial for the advancement of our knowledge of KS, especially for associating its symptoms with lesions in various thalamic nuclei. A necessary requirement for the advancement of studies on KS is the broad acceptance of a comprehensive definition and definite diagnostic criteria. Therefore, in this review, we propose such a definition of KS and draft outlines for prospective diagnostic criteria. Keywords: Korsakoff’s syndrome, alcohol amnestic disorder, Wernicke encephalopathy, thiamine deficiency, ethanol neurotoxicity, thalamus, memory, executive function, historyArts NJMWalvoort SJWKessels RPCDove Medical PressarticleKorsakoff’s SyndromeAlcohol Amnestic DisorderWernicke EncephalopathyThiamine DeficiencyEthanol NeurotoxicityThalamusMemoryNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2875-2890 (2017)
institution DOAJ
collection DOAJ
language EN
topic Korsakoff’s Syndrome
Alcohol Amnestic Disorder
Wernicke Encephalopathy
Thiamine Deficiency
Ethanol Neurotoxicity
Thalamus
Memory
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Korsakoff’s Syndrome
Alcohol Amnestic Disorder
Wernicke Encephalopathy
Thiamine Deficiency
Ethanol Neurotoxicity
Thalamus
Memory
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Arts NJM
Walvoort SJW
Kessels RPC
Korsakoff’s syndrome: a critical review
description Nicolaas JM Arts,1,2 Serge JW Walvoort,1 Roy PC Kessels1,3,4 1Centre of Excellence for Korsakoff and Alcohol-Related Cognitive Disorders, Vincent van Gogh Institute for Psychiatry, Venray, 2Neuropsychiatry Center Thalamus, Institution for Integrated Mental Health Care Pro Persona, Wolfheze, 3Department of Neuropsychology and Rehabilitation Psychology, Donders Institute for Brain, Cognition and Behaviour, Radboud University, 4Department of Medical Psychology, Radboud University Medical Center, Nijmegen, the Netherlands Abstract: In this review, we present a survey on Korsakoff’s syndrome (KS), a residual syndrome in patients who suffered from a Wernicke encephalopathy (WE) that is predominantly characterized by global amnesia, and in more severe cases also by cognitive and behavioral dysfunction. We describe the history of KS and its definition, its epidemiology, and the lack of consensus criteria for its diagnosis. The cognitive and behavioral symptoms of KS, which include anterograde and retrograde amnesia, executive dysfunction, confabulation, apathy, as well as affective and social-cognitive impairments, are discussed. Moreover, recent insights into the underlying neurocognitive mechanisms of these symptoms are presented. In addition, the evidence so far on the etiology of KS is examined, highlighting the role of thiamine and alcohol and discussing the continuity hypothesis. Furthermore, the neuropathology of KS is reviewed, focusing on abnormalities in the diencephalon, including the mammillary bodies and thalamic nuclei. Pharmacological treatment options and nonpharmacological interventions, such as those based on cognitive rehabilitation, are discussed. Our review shows that thiamine deficiency (TD) is a crucial factor in the etiology of KS. Although alcohol abuse is by far the most important context in which TD occurs, there is no convincing evidence for an essential contribution of ethanol neurotoxicity (EN) to the development of WE or to the progression of WE to KS. Future research on the postmortem histopathological analysis of brain tissues of KS patients is crucial for the advancement of our knowledge of KS, especially for associating its symptoms with lesions in various thalamic nuclei. A necessary requirement for the advancement of studies on KS is the broad acceptance of a comprehensive definition and definite diagnostic criteria. Therefore, in this review, we propose such a definition of KS and draft outlines for prospective diagnostic criteria. Keywords: Korsakoff’s syndrome, alcohol amnestic disorder, Wernicke encephalopathy, thiamine deficiency, ethanol neurotoxicity, thalamus, memory, executive function, history
format article
author Arts NJM
Walvoort SJW
Kessels RPC
author_facet Arts NJM
Walvoort SJW
Kessels RPC
author_sort Arts NJM
title Korsakoff’s syndrome: a critical review
title_short Korsakoff’s syndrome: a critical review
title_full Korsakoff’s syndrome: a critical review
title_fullStr Korsakoff’s syndrome: a critical review
title_full_unstemmed Korsakoff’s syndrome: a critical review
title_sort korsakoff’s syndrome: a critical review
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/540152734c164b6da3a406552b46fe22
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AT walvoortsjw korsakoffrsquossyndromeacriticalreview
AT kesselsrpc korsakoffrsquossyndromeacriticalreview
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