Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis

Satoshi Ueda,1 Takeshi Sakayori,1 Ataru Omori,2 Hajime Fukuta,3 Takashi Kobayashi,3 Kousuke Ishizaka,1 Tomoyuki Saijo,4 Yoshiro Okubo1 1Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan; 2Tamachuo Hospital, Tokyo, Japan; 3Kurumegaoka Hospital, Tokyo, Japan; 4Saijo Clinic, Tokyo, Ja...

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Autores principales:	Ueda S, Sakayori T, Omori A, Fukuta H, Kobayashi T, Ishizaka K, Saijo T, Okubo Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	neuroleptic-induced deficit syndrome (NIDS) bipolar disorder psychosis atypical antipsychotics electroconvulsive therapy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5404f37f745945cb83d82c0428467c22
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spelling	oai:doaj.org-article:5404f37f745945cb83d82c0428467c222021-12-02T02:16:33ZNeuroleptic-induced deficit syndrome in bipolar disorder with psychosis1178-2021https://doaj.org/article/5404f37f745945cb83d82c0428467c222016-02-01T00:00:00Zhttps://www.dovepress.com/neuroleptic-induced-deficit-syndrome-in-bipolar-disorder-with-psychosi-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Satoshi Ueda,1 Takeshi Sakayori,1 Ataru Omori,2 Hajime Fukuta,3 Takashi Kobayashi,3 Kousuke Ishizaka,1 Tomoyuki Saijo,4 Yoshiro Okubo1 1Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan; 2Tamachuo Hospital, Tokyo, Japan; 3Kurumegaoka Hospital, Tokyo, Japan; 4Saijo Clinic, Tokyo, Japan Abstract: Neuroleptics can induce not only physical adverse effects but also mental effects that produce deficit status in thought, affect, cognition, and behavior. This condition is known as neuroleptic-induced deficit syndrome (NIDS), which includes apathy, lack of initiative, anhedonia, indifference, blunted affect, and reduced insight into disease. Although this old concept now appears almost forgotten, neuroleptics, whether typical or atypical, can make depression or bipolar disorder resemble other more refractory conditions, readily leading to mistaken diagnosis and inappropriate treatment. The authors describe three cases of NIDS superimposed on depressive phase in bipolar disorder with psychosis, where the attending psychiatrist’s failure to recognize NIDS prevented patients from receiving effective treatment and achieving remission. All cases achieved remission after reduction of neuroleptics and intensive therapy, including electroconvulsive therapy, for bipolar depression. The concept of NIDS was originally introduced for schizophrenia, and it has rarely been highlighted in other diseases. In recent years, however, atypical antipsychotics are being more often administered to patients with bipolar disorder. Psychiatrists, therefore, should also remember and exercise caution regarding NIDS in the pharmacotherapy of bipolar disorder with and without psychosis. The authors believe that the concept of NIDS needs to be reappraised in current psychiatry. Keywords: neuroleptic-induced deficit syndrome (NIDS), bipolar disorder, psychosis, atypical antipsychotics, electroconvulsive therapyUeda SSakayori TOmori AFukuta HKobayashi TIshizaka KSaijo TOkubo YDove Medical Pressarticleneuroleptic-induced deficit syndrome (NIDS)bipolar disorderpsychosisatypical antipsychoticselectroconvulsive therapyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 265-268 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	neuroleptic-induced deficit syndrome (NIDS) bipolar disorder psychosis atypical antipsychotics electroconvulsive therapy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	neuroleptic-induced deficit syndrome (NIDS) bipolar disorder psychosis atypical antipsychotics electroconvulsive therapy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ueda S Sakayori T Omori A Fukuta H Kobayashi T Ishizaka K Saijo T Okubo Y Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis
description	Satoshi Ueda,1 Takeshi Sakayori,1 Ataru Omori,2 Hajime Fukuta,3 Takashi Kobayashi,3 Kousuke Ishizaka,1 Tomoyuki Saijo,4 Yoshiro Okubo1 1Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan; 2Tamachuo Hospital, Tokyo, Japan; 3Kurumegaoka Hospital, Tokyo, Japan; 4Saijo Clinic, Tokyo, Japan Abstract: Neuroleptics can induce not only physical adverse effects but also mental effects that produce deficit status in thought, affect, cognition, and behavior. This condition is known as neuroleptic-induced deficit syndrome (NIDS), which includes apathy, lack of initiative, anhedonia, indifference, blunted affect, and reduced insight into disease. Although this old concept now appears almost forgotten, neuroleptics, whether typical or atypical, can make depression or bipolar disorder resemble other more refractory conditions, readily leading to mistaken diagnosis and inappropriate treatment. The authors describe three cases of NIDS superimposed on depressive phase in bipolar disorder with psychosis, where the attending psychiatrist’s failure to recognize NIDS prevented patients from receiving effective treatment and achieving remission. All cases achieved remission after reduction of neuroleptics and intensive therapy, including electroconvulsive therapy, for bipolar depression. The concept of NIDS was originally introduced for schizophrenia, and it has rarely been highlighted in other diseases. In recent years, however, atypical antipsychotics are being more often administered to patients with bipolar disorder. Psychiatrists, therefore, should also remember and exercise caution regarding NIDS in the pharmacotherapy of bipolar disorder with and without psychosis. The authors believe that the concept of NIDS needs to be reappraised in current psychiatry. Keywords: neuroleptic-induced deficit syndrome (NIDS), bipolar disorder, psychosis, atypical antipsychotics, electroconvulsive therapy
format	article
author	Ueda S Sakayori T Omori A Fukuta H Kobayashi T Ishizaka K Saijo T Okubo Y
author_facet	Ueda S Sakayori T Omori A Fukuta H Kobayashi T Ishizaka K Saijo T Okubo Y
author_sort	Ueda S
title	Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis
title_short	Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis
title_full	Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis
title_fullStr	Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis
title_full_unstemmed	Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis
title_sort	neuroleptic-induced deficit syndrome in bipolar disorder with psychosis
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/5404f37f745945cb83d82c0428467c22
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_version_	1718402595248144384

Neuroleptic-induced deficit syndrome in bipolar disorder with psychosis

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