Identification of LIG1 and LIG3 as prognostic biomarkers in breast cancer

DNA ligase (LIG) plays a key role in connecting the 3′-OH end of a DNA strand to the 5′-P end of another DNA strand, resulting in the formation of a phosphodiester bond. It has been reported that LIGs (including LIG1, LIG3 and LIG4) play important roles in the occurrence and progression of many canc...

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Autores principales:	Sun Lin, Liu Xinyu, Song Siqi, Feng Lingjun, Shi Chunying, Sun Zhipeng, Chen Bo, Hou Haiqing
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	lig breast cancer biomarker prognosis Medicine R
Acceso en línea:	https://doaj.org/article/540d63d489a941909d329243aec6c2a6
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spelling	oai:doaj.org-article:540d63d489a941909d329243aec6c2a62021-12-05T14:10:55ZIdentification of LIG1 and LIG3 as prognostic biomarkers in breast cancer2391-546310.1515/med-2021-0388https://doaj.org/article/540d63d489a941909d329243aec6c2a62021-11-01T00:00:00Zhttps://doi.org/10.1515/med-2021-0388https://doaj.org/toc/2391-5463DNA ligase (LIG) plays a key role in connecting the 3′-OH end of a DNA strand to the 5′-P end of another DNA strand, resulting in the formation of a phosphodiester bond. It has been reported that LIGs (including LIG1, LIG3 and LIG4) play important roles in the occurrence and progression of many cancers. However, the role of LIGs in breast cancer (BC) is still unclear. In this study, we aim to reveal the expression level, function, and prognostic value of LIGs in BC. Bioinformatic tools were used to study the expression level, potential function and prognostic value of LIG1 and LIG3 in BC patients. ENCORI was used to predict microRNAs (miRNAs) that regulate LIG1 and LIG3 and established a valuable miRNA–mRNA regulation network for BC. We found that the expression of LIG1 and LIG3 was upregulated in BC and predicted high relapse-free survival (RFS) in BC patients. Functional annotation analysis was performed to reveal the role of LIG1 and LIG3 in BC. In addition, hsa-miR-22-3p was identified to be potentially involved in the regulation of LIG3. We suggest that LIG1 and LIG3 are novel valuable prognostic biomarkers for BC and has-miRNA-22-3p may be a potential therapeutic target for BC.Sun LinLiu XinyuSong SiqiFeng LingjunShi ChunyingSun ZhipengChen BoHou HaiqingDe Gruyterarticleligbreast cancerbiomarkerprognosisMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 1705-1717 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lig breast cancer biomarker prognosis Medicine R
spellingShingle	lig breast cancer biomarker prognosis Medicine R Sun Lin Liu Xinyu Song Siqi Feng Lingjun Shi Chunying Sun Zhipeng Chen Bo Hou Haiqing Identification of LIG1 and LIG3 as prognostic biomarkers in breast cancer
description	DNA ligase (LIG) plays a key role in connecting the 3′-OH end of a DNA strand to the 5′-P end of another DNA strand, resulting in the formation of a phosphodiester bond. It has been reported that LIGs (including LIG1, LIG3 and LIG4) play important roles in the occurrence and progression of many cancers. However, the role of LIGs in breast cancer (BC) is still unclear. In this study, we aim to reveal the expression level, function, and prognostic value of LIGs in BC. Bioinformatic tools were used to study the expression level, potential function and prognostic value of LIG1 and LIG3 in BC patients. ENCORI was used to predict microRNAs (miRNAs) that regulate LIG1 and LIG3 and established a valuable miRNA–mRNA regulation network for BC. We found that the expression of LIG1 and LIG3 was upregulated in BC and predicted high relapse-free survival (RFS) in BC patients. Functional annotation analysis was performed to reveal the role of LIG1 and LIG3 in BC. In addition, hsa-miR-22-3p was identified to be potentially involved in the regulation of LIG3. We suggest that LIG1 and LIG3 are novel valuable prognostic biomarkers for BC and has-miRNA-22-3p may be a potential therapeutic target for BC.
format	article
author	Sun Lin Liu Xinyu Song Siqi Feng Lingjun Shi Chunying Sun Zhipeng Chen Bo Hou Haiqing
author_facet	Sun Lin Liu Xinyu Song Siqi Feng Lingjun Shi Chunying Sun Zhipeng Chen Bo Hou Haiqing
author_sort	Sun Lin
title	Identification of LIG1 and LIG3 as prognostic biomarkers in breast cancer
title_short	Identification of LIG1 and LIG3 as prognostic biomarkers in breast cancer
title_full	Identification of LIG1 and LIG3 as prognostic biomarkers in breast cancer
title_fullStr	Identification of LIG1 and LIG3 as prognostic biomarkers in breast cancer
title_full_unstemmed	Identification of LIG1 and LIG3 as prognostic biomarkers in breast cancer
title_sort	identification of lig1 and lig3 as prognostic biomarkers in breast cancer
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/540d63d489a941909d329243aec6c2a6
work_keys_str_mv	AT sunlin identificationoflig1andlig3asprognosticbiomarkersinbreastcancer AT liuxinyu identificationoflig1andlig3asprognosticbiomarkersinbreastcancer AT songsiqi identificationoflig1andlig3asprognosticbiomarkersinbreastcancer AT fenglingjun identificationoflig1andlig3asprognosticbiomarkersinbreastcancer AT shichunying identificationoflig1andlig3asprognosticbiomarkersinbreastcancer AT sunzhipeng identificationoflig1andlig3asprognosticbiomarkersinbreastcancer AT chenbo identificationoflig1andlig3asprognosticbiomarkersinbreastcancer AT houhaiqing identificationoflig1andlig3asprognosticbiomarkersinbreastcancer
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Identification of LIG1 and LIG3 as prognostic biomarkers in breast cancer

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