Phytochemical profile and nutraceutical value of old and modern common wheat cultivars.

Among health-promoting phytochemicals in whole grains, phenolic compounds have gained attention as they have strong antioxidant properties and can protect against many degenerative diseases. Aim of this study was to profile grain phenolic extracts of one modern and five old common wheat (Triticum ae...

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Autores principales:	Emanuela Leoncini, Cecilia Prata, Marco Malaguti, Ilaria Marotti, Antonio Segura-Carretero, Pietro Catizone, Giovanni Dinelli, Silvana Hrelia
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/54102ef654304eae9f5519acb0bef7ff
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spelling	oai:doaj.org-article:54102ef654304eae9f5519acb0bef7ff2021-11-18T08:13:52ZPhytochemical profile and nutraceutical value of old and modern common wheat cultivars.1932-620310.1371/journal.pone.0045997https://doaj.org/article/54102ef654304eae9f5519acb0bef7ff2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23049918/?tool=EBIhttps://doaj.org/toc/1932-6203Among health-promoting phytochemicals in whole grains, phenolic compounds have gained attention as they have strong antioxidant properties and can protect against many degenerative diseases. Aim of this study was to profile grain phenolic extracts of one modern and five old common wheat (Triticum aestivum L.) varieties and to evaluate their potential antiproliferative or cytoprotective effect in different cell culture systems.Wheat extracts were characterized in terms of antioxidant activity and phenolic composition (HPLC/ESI-TOF-MS profile, polyphenol and flavonoid contents). Results showed that antioxidant activity (FRAP and DPPH) is mostly influenced by flavonoid (both bound and free) content and by the ratio flavonoids/polyphenols. Using a leukemic cell line, HL60, and primary cultures of neonatal rat cardiomyocytes, the potential antiproliferative or cytoprotective effects of different wheat genotypes were evaluated in terms of intracellular reactive oxygen species levels and cell viability. All tested wheat phenolic extracts exerted dose-dependent cytoprotective and antiproliferative effects on cardiomyocytes and HL60 cells, respectively. Due to the peculiar phenolic pattern of each wheat variety, a significant genotype effect was highlighted. On the whole, the most relevant scavenging effect was found for the old variety Verna. No significant differences in terms of anti-proliferative activities among wheat genotypes was observed.Results reported in this study evidenced a correspondence between the in vitro antioxidant activity and potential healthy properties of different extracts. This suggests that an increased intake of wheat grain derived products could represent an effective strategy to achieve both chemoprevention and protection against oxidative stress related diseases.Emanuela LeonciniCecilia PrataMarco MalagutiIlaria MarottiAntonio Segura-CarreteroPietro CatizoneGiovanni DinelliSilvana HreliaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e45997 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emanuela Leoncini Cecilia Prata Marco Malaguti Ilaria Marotti Antonio Segura-Carretero Pietro Catizone Giovanni Dinelli Silvana Hrelia Phytochemical profile and nutraceutical value of old and modern common wheat cultivars.
description	Among health-promoting phytochemicals in whole grains, phenolic compounds have gained attention as they have strong antioxidant properties and can protect against many degenerative diseases. Aim of this study was to profile grain phenolic extracts of one modern and five old common wheat (Triticum aestivum L.) varieties and to evaluate their potential antiproliferative or cytoprotective effect in different cell culture systems.Wheat extracts were characterized in terms of antioxidant activity and phenolic composition (HPLC/ESI-TOF-MS profile, polyphenol and flavonoid contents). Results showed that antioxidant activity (FRAP and DPPH) is mostly influenced by flavonoid (both bound and free) content and by the ratio flavonoids/polyphenols. Using a leukemic cell line, HL60, and primary cultures of neonatal rat cardiomyocytes, the potential antiproliferative or cytoprotective effects of different wheat genotypes were evaluated in terms of intracellular reactive oxygen species levels and cell viability. All tested wheat phenolic extracts exerted dose-dependent cytoprotective and antiproliferative effects on cardiomyocytes and HL60 cells, respectively. Due to the peculiar phenolic pattern of each wheat variety, a significant genotype effect was highlighted. On the whole, the most relevant scavenging effect was found for the old variety Verna. No significant differences in terms of anti-proliferative activities among wheat genotypes was observed.Results reported in this study evidenced a correspondence between the in vitro antioxidant activity and potential healthy properties of different extracts. This suggests that an increased intake of wheat grain derived products could represent an effective strategy to achieve both chemoprevention and protection against oxidative stress related diseases.
format	article
author	Emanuela Leoncini Cecilia Prata Marco Malaguti Ilaria Marotti Antonio Segura-Carretero Pietro Catizone Giovanni Dinelli Silvana Hrelia
author_facet	Emanuela Leoncini Cecilia Prata Marco Malaguti Ilaria Marotti Antonio Segura-Carretero Pietro Catizone Giovanni Dinelli Silvana Hrelia
author_sort	Emanuela Leoncini
title	Phytochemical profile and nutraceutical value of old and modern common wheat cultivars.
title_short	Phytochemical profile and nutraceutical value of old and modern common wheat cultivars.
title_full	Phytochemical profile and nutraceutical value of old and modern common wheat cultivars.
title_fullStr	Phytochemical profile and nutraceutical value of old and modern common wheat cultivars.
title_full_unstemmed	Phytochemical profile and nutraceutical value of old and modern common wheat cultivars.
title_sort	phytochemical profile and nutraceutical value of old and modern common wheat cultivars.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/54102ef654304eae9f5519acb0bef7ff
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Phytochemical profile and nutraceutical value of old and modern common wheat cultivars.

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