Residential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis.

<h4>Context</h4>Studies from different geographical regions have assessed the relations between indoor dampness and mold problems and the risk of asthma, but the evidence has been inconclusive.<h4>Objective</h4>To assess the relations between indicators of indoor dampness and...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Reginald Quansah, Maritta S Jaakkola, Timo T Hugg, Sirpa A M Heikkinen, Jouni J K Jaakkola
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/54122355a878443da51bb15e7c1bb21d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:54122355a878443da51bb15e7c1bb21d
record_format	dspace
spelling	oai:doaj.org-article:54122355a878443da51bb15e7c1bb21d2021-11-18T08:09:50ZResidential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis.1932-620310.1371/journal.pone.0047526https://doaj.org/article/54122355a878443da51bb15e7c1bb21d2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23144822/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Context</h4>Studies from different geographical regions have assessed the relations between indoor dampness and mold problems and the risk of asthma, but the evidence has been inconclusive.<h4>Objective</h4>To assess the relations between indicators of indoor dampness and mold problems and the risk of developing new asthma, and to investigate whether such relations differ according to the type of exposure.<h4>Data sources</h4>A systematic literature search of PubMed database from 1990 through March 2012 and the reference lists of recent reviews and of relevant articles identified in our search.<h4>Study selection</h4>Cohort/longitudinal and incident case-control studies assessing the relation between mold/dampness and new asthma were included.<h4>Data extraction</h4>Three authors independently evaluated eligible articles and extracted relevant information using a structured form.<h4>Synthesis</h4>SIXTEEN STUDIES WERE INCLUDED: 11 cohort and 5 incident case-control studies. The summary effect estimates (EE) based on the highest and lowest estimates for the relation between any exposure and onset of asthma were for the highest estimates 1.48 (95% confidence interval [CI] 1.23-1.78, random-effects model, Q-statistic 38.75 (16), P = 0.001) ; and for the lowest estimates: 1.27 (95% CI 1.06-1.53, random-effects model, Q-statistic 38.12 (16), P = 0.000) [corrected].The summary effect estimates were significantly elevated for dampness (fixed-effects model: EE 1.33, 95% CI 1.12-1.56, Q-statistic 8.22 (9), P = 0.413), visible mold (random-effects model; EE 1.29, 95% CI 1.04-1.60, 30.30 (12), P = 0.001), and mold odor (random-effects model; EE 1.73, 95% CI 1.19-2.50, Q-statistics 14.85 (8), P = 0.038), but not for water damage (fixed-effects model; EE 1.12, 95% CI 0.98-1.27). Heterogeneity was observed in the study-specific effect estimates.<h4>Conclusion</h4>The evidence indicates that dampness and molds in the home are determinants of developing asthma. The association of the presence of visible mold and especially mold odor to the risk of asthma points towards mold-related causal agents.Reginald QuansahMaritta S JaakkolaTimo T HuggSirpa A M HeikkinenJouni J K JaakkolaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e47526 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Reginald Quansah Maritta S Jaakkola Timo T Hugg Sirpa A M Heikkinen Jouni J K Jaakkola Residential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis.
description	<h4>Context</h4>Studies from different geographical regions have assessed the relations between indoor dampness and mold problems and the risk of asthma, but the evidence has been inconclusive.<h4>Objective</h4>To assess the relations between indicators of indoor dampness and mold problems and the risk of developing new asthma, and to investigate whether such relations differ according to the type of exposure.<h4>Data sources</h4>A systematic literature search of PubMed database from 1990 through March 2012 and the reference lists of recent reviews and of relevant articles identified in our search.<h4>Study selection</h4>Cohort/longitudinal and incident case-control studies assessing the relation between mold/dampness and new asthma were included.<h4>Data extraction</h4>Three authors independently evaluated eligible articles and extracted relevant information using a structured form.<h4>Synthesis</h4>SIXTEEN STUDIES WERE INCLUDED: 11 cohort and 5 incident case-control studies. The summary effect estimates (EE) based on the highest and lowest estimates for the relation between any exposure and onset of asthma were for the highest estimates 1.48 (95% confidence interval [CI] 1.23-1.78, random-effects model, Q-statistic 38.75 (16), P = 0.001) ; and for the lowest estimates: 1.27 (95% CI 1.06-1.53, random-effects model, Q-statistic 38.12 (16), P = 0.000) [corrected].The summary effect estimates were significantly elevated for dampness (fixed-effects model: EE 1.33, 95% CI 1.12-1.56, Q-statistic 8.22 (9), P = 0.413), visible mold (random-effects model; EE 1.29, 95% CI 1.04-1.60, 30.30 (12), P = 0.001), and mold odor (random-effects model; EE 1.73, 95% CI 1.19-2.50, Q-statistics 14.85 (8), P = 0.038), but not for water damage (fixed-effects model; EE 1.12, 95% CI 0.98-1.27). Heterogeneity was observed in the study-specific effect estimates.<h4>Conclusion</h4>The evidence indicates that dampness and molds in the home are determinants of developing asthma. The association of the presence of visible mold and especially mold odor to the risk of asthma points towards mold-related causal agents.
format	article
author	Reginald Quansah Maritta S Jaakkola Timo T Hugg Sirpa A M Heikkinen Jouni J K Jaakkola
author_facet	Reginald Quansah Maritta S Jaakkola Timo T Hugg Sirpa A M Heikkinen Jouni J K Jaakkola
author_sort	Reginald Quansah
title	Residential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis.
title_short	Residential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis.
title_full	Residential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis.
title_fullStr	Residential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis.
title_full_unstemmed	Residential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis.
title_sort	residential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/54122355a878443da51bb15e7c1bb21d
work_keys_str_mv	AT reginaldquansah residentialdampnessandmoldsandtheriskofdevelopingasthmaasystematicreviewandmetaanalysis AT marittasjaakkola residentialdampnessandmoldsandtheriskofdevelopingasthmaasystematicreviewandmetaanalysis AT timothugg residentialdampnessandmoldsandtheriskofdevelopingasthmaasystematicreviewandmetaanalysis AT sirpaamheikkinen residentialdampnessandmoldsandtheriskofdevelopingasthmaasystematicreviewandmetaanalysis AT jounijkjaakkola residentialdampnessandmoldsandtheriskofdevelopingasthmaasystematicreviewandmetaanalysis
_version_	1718422105862701056

Residential dampness and molds and the risk of developing asthma: a systematic review and meta-analysis.

Ejemplares similares