Effect of additive particles on mechanical, thermal, and cell functioning properties of poly(methyl methacrylate) cement

Morshed Khandaker,1 Melville B Vaughan,2 Tracy L Morris,3 Jeremiah J White,1 Zhaotong Meng1 1Department of Engineering and Physics, 2Department of Biology, 3Department of Mathematics and Statistics, University of Central Oklahoma, Edmond, OK, USA Abstract: The most common bone cement material use...

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Autores principales:	Khandaker M, Vaughan MB, Morris TL, White JJ, Meng Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5413406d0e934cc2af1a356e3d90c501
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spelling	oai:doaj.org-article:5413406d0e934cc2af1a356e3d90c5012021-12-02T02:32:06ZEffect of additive particles on mechanical, thermal, and cell functioning properties of poly(methyl methacrylate) cement1178-2013https://doaj.org/article/5413406d0e934cc2af1a356e3d90c5012014-05-01T00:00:00Zhttp://www.dovepress.com/effect-of-additive-particles-on-mechanical-thermal-and-cell-functionin-a17013https://doaj.org/toc/1178-2013 Morshed Khandaker,1 Melville B Vaughan,2 Tracy L Morris,3 Jeremiah J White,1 Zhaotong Meng1 1Department of Engineering and Physics, 2Department of Biology, 3Department of Mathematics and Statistics, University of Central Oklahoma, Edmond, OK, USA Abstract: The most common bone cement material used clinically today for orthopedic surgery is poly(methyl methacrylate) (PMMA). Conventional PMMA bone cement has several mechanical, thermal, and biological disadvantages. To overcome these problems, researchers have investigated combinations of PMMA bone cement and several bioactive particles (micrometers to nanometers in size), such as magnesium oxide, hydroxyapatite, chitosan, barium sulfate, and silica. A study comparing the effect of these individual additives on the mechanical, thermal, and cell functional properties of PMMA would be important to enable selection of suitable additives and design improved PMMA cement for orthopedic applications. Therefore, the goal of this study was to determine the effect of inclusion of magnesium oxide, hydroxyapatite, chitosan, barium sulfate, and silica additives in PMMA on the mechanical, thermal, and cell functional performance of PMMA. American Society for Testing and Materials standard three-point bend flexural and fracture tests were conducted to determine the flexural strength, flexural modulus, and fracture toughness of the different PMMA samples. A custom-made temperature measurement system was used to determine maximum curing temperature and the time needed for each PMMA sample to reach its maximum curing temperature. Osteoblast adhesion and proliferation experiments were performed to determine cell viability using the different PMMA cements. We found that flexural strength and fracture toughness were significantly greater for PMMA specimens that incorporated silica than for the other specimens. All additives prolonged the time taken to reach maximum curing temperature and significantly improved cell adhesion of the PMMA samples. The results of this study could be useful for improving the union of implant-PMMA or bone-PMMA interfaces by incorporating nanoparticles into PMMA cement for orthopedic and orthodontic applications. Keywords: poly(methyl methacrylate), magnesium oxide, hydroxyapatite, chitosan, barium sulfate, silica, flexural strength, fracture toughness, curing temperature, cell viabilityKhandaker MVaughan MBMorris TLWhite JJMeng ZDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 2699-2712 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Khandaker M Vaughan MB Morris TL White JJ Meng Z Effect of additive particles on mechanical, thermal, and cell functioning properties of poly(methyl methacrylate) cement
description	Morshed Khandaker,1 Melville B Vaughan,2 Tracy L Morris,3 Jeremiah J White,1 Zhaotong Meng1 1Department of Engineering and Physics, 2Department of Biology, 3Department of Mathematics and Statistics, University of Central Oklahoma, Edmond, OK, USA Abstract: The most common bone cement material used clinically today for orthopedic surgery is poly(methyl methacrylate) (PMMA). Conventional PMMA bone cement has several mechanical, thermal, and biological disadvantages. To overcome these problems, researchers have investigated combinations of PMMA bone cement and several bioactive particles (micrometers to nanometers in size), such as magnesium oxide, hydroxyapatite, chitosan, barium sulfate, and silica. A study comparing the effect of these individual additives on the mechanical, thermal, and cell functional properties of PMMA would be important to enable selection of suitable additives and design improved PMMA cement for orthopedic applications. Therefore, the goal of this study was to determine the effect of inclusion of magnesium oxide, hydroxyapatite, chitosan, barium sulfate, and silica additives in PMMA on the mechanical, thermal, and cell functional performance of PMMA. American Society for Testing and Materials standard three-point bend flexural and fracture tests were conducted to determine the flexural strength, flexural modulus, and fracture toughness of the different PMMA samples. A custom-made temperature measurement system was used to determine maximum curing temperature and the time needed for each PMMA sample to reach its maximum curing temperature. Osteoblast adhesion and proliferation experiments were performed to determine cell viability using the different PMMA cements. We found that flexural strength and fracture toughness were significantly greater for PMMA specimens that incorporated silica than for the other specimens. All additives prolonged the time taken to reach maximum curing temperature and significantly improved cell adhesion of the PMMA samples. The results of this study could be useful for improving the union of implant-PMMA or bone-PMMA interfaces by incorporating nanoparticles into PMMA cement for orthopedic and orthodontic applications. Keywords: poly(methyl methacrylate), magnesium oxide, hydroxyapatite, chitosan, barium sulfate, silica, flexural strength, fracture toughness, curing temperature, cell viability
format	article
author	Khandaker M Vaughan MB Morris TL White JJ Meng Z
author_facet	Khandaker M Vaughan MB Morris TL White JJ Meng Z
author_sort	Khandaker M
title	Effect of additive particles on mechanical, thermal, and cell functioning properties of poly(methyl methacrylate) cement
title_short	Effect of additive particles on mechanical, thermal, and cell functioning properties of poly(methyl methacrylate) cement
title_full	Effect of additive particles on mechanical, thermal, and cell functioning properties of poly(methyl methacrylate) cement
title_fullStr	Effect of additive particles on mechanical, thermal, and cell functioning properties of poly(methyl methacrylate) cement
title_full_unstemmed	Effect of additive particles on mechanical, thermal, and cell functioning properties of poly(methyl methacrylate) cement
title_sort	effect of additive particles on mechanical, thermal, and cell functioning properties of poly(methyl methacrylate) cement
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/5413406d0e934cc2af1a356e3d90c501
work_keys_str_mv	AT khandakerm effectofadditiveparticlesonmechanicalthermalandcellfunctioningpropertiesofpolymethylmethacrylatecement AT vaughanmb effectofadditiveparticlesonmechanicalthermalandcellfunctioningpropertiesofpolymethylmethacrylatecement AT morristl effectofadditiveparticlesonmechanicalthermalandcellfunctioningpropertiesofpolymethylmethacrylatecement AT whitejj effectofadditiveparticlesonmechanicalthermalandcellfunctioningpropertiesofpolymethylmethacrylatecement AT mengz effectofadditiveparticlesonmechanicalthermalandcellfunctioningpropertiesofpolymethylmethacrylatecement
_version_	1718402407899070464

Effect of additive particles on mechanical, thermal, and cell functioning properties of poly(methyl methacrylate) cement

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