Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect

Yuan Wang,1,2 Yuliang Wang,2 Wenbin Ma,2 Shujun Lu,2 Jinbo Chen,2 Lili Cao1 1Department of Neurology, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 2Department of Neurology, Binzhou Medical University Hospital, Binzhou, People’s Republic of China Purp...

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Autores principales:	Wang Y, Ma W, Lu S, Chen J, Cao L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	cognitive impairment pseudobulbar affect cerebral infarction neuropsychological tests cognitive domain Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/5413fc95463a446aa2f754620232a97a
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spelling	oai:doaj.org-article:5413fc95463a446aa2f754620232a97a2021-12-02T05:30:45ZCorrelation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect1178-2021https://doaj.org/article/5413fc95463a446aa2f754620232a97a2018-03-01T00:00:00Zhttps://www.dovepress.com/correlation-between-cognitive-impairment-during-the-acute-phase-of-fir-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yuan Wang,1,2 Yuliang Wang,2 Wenbin Ma,2 Shujun Lu,2 Jinbo Chen,2 Lili Cao1 1Department of Neurology, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 2Department of Neurology, Binzhou Medical University Hospital, Binzhou, People’s Republic of China Purpose: The relationship between cognitive impairment during the acute phase of first cerebral infarction and the development of long-term pseudobulbar affect (PBA) has not been elucidated. Therefore, in this study, we aimed to determine if cognitive impairment during the acute phase of cerebral infarction will increase the risk of long-term post-infarction PBA.Patients and methods: This was a nested case–control study using a prospective approach. A consecutive multicenter matched 1:1 case–control study of cognitive impairment cases following acute cerebral infarction (N=26) with 26 sex-, education years-, and age-matched controls. Univariate and multivariate conditional logistic regression analyses were performed to study the clinical features and changes in cognitive domain as well as the risk factors for PBA.Results: Long-term PBA was independently predicted by low Montreal cognitive assessment (MoCA) scores at baseline. Multivariable regression models showed that post-infarction low MoCA scores remained independent predictors of long-term PBA (odds ratio [OR]=0.72; 95% confidence interval [CI]=0.54–0.95; P=0.018). Among all cognitive disorders, digit span test (DST) scores (OR=0.39; 95% CI=0.16–0.91, P=0.030), StroopC time (OR=1.15; 95% CI=1.01–1.31; P=0.037), and clock-drawing task (CDT) scores (OR=0.62; 95% CI=0.42–0.90; P=0.013) were found to be the independent risk factors for PBA.Conclusion: Cognitive impairment during the acute phase of cerebral infarction increased the risk of cerebral infarction-induced long-term PBA. Development of PBA was closely associated with executive function, attention, and visuospatial disorder. Keywords: cognitive impairment, pseudobulbar affect, cerebral infarction, neuropsychological tests, cognitive domainWang YWang YMa WLu SChen JCao LDove Medical Pressarticlecognitive impairmentpseudobulbar affectcerebral infarctionneuropsychological testscognitive domainNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 871-877 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	cognitive impairment pseudobulbar affect cerebral infarction neuropsychological tests cognitive domain Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	cognitive impairment pseudobulbar affect cerebral infarction neuropsychological tests cognitive domain Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wang Y Wang Y Ma W Lu S Chen J Cao L Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect
description	Yuan Wang,1,2 Yuliang Wang,2 Wenbin Ma,2 Shujun Lu,2 Jinbo Chen,2 Lili Cao1 1Department of Neurology, Qilu Hospital of Shandong University, Jinan, People’s Republic of China; 2Department of Neurology, Binzhou Medical University Hospital, Binzhou, People’s Republic of China Purpose: The relationship between cognitive impairment during the acute phase of first cerebral infarction and the development of long-term pseudobulbar affect (PBA) has not been elucidated. Therefore, in this study, we aimed to determine if cognitive impairment during the acute phase of cerebral infarction will increase the risk of long-term post-infarction PBA.Patients and methods: This was a nested case–control study using a prospective approach. A consecutive multicenter matched 1:1 case–control study of cognitive impairment cases following acute cerebral infarction (N=26) with 26 sex-, education years-, and age-matched controls. Univariate and multivariate conditional logistic regression analyses were performed to study the clinical features and changes in cognitive domain as well as the risk factors for PBA.Results: Long-term PBA was independently predicted by low Montreal cognitive assessment (MoCA) scores at baseline. Multivariable regression models showed that post-infarction low MoCA scores remained independent predictors of long-term PBA (odds ratio [OR]=0.72; 95% confidence interval [CI]=0.54–0.95; P=0.018). Among all cognitive disorders, digit span test (DST) scores (OR=0.39; 95% CI=0.16–0.91, P=0.030), StroopC time (OR=1.15; 95% CI=1.01–1.31; P=0.037), and clock-drawing task (CDT) scores (OR=0.62; 95% CI=0.42–0.90; P=0.013) were found to be the independent risk factors for PBA.Conclusion: Cognitive impairment during the acute phase of cerebral infarction increased the risk of cerebral infarction-induced long-term PBA. Development of PBA was closely associated with executive function, attention, and visuospatial disorder. Keywords: cognitive impairment, pseudobulbar affect, cerebral infarction, neuropsychological tests, cognitive domain
format	article
author	Wang Y Wang Y Ma W Lu S Chen J Cao L
author_facet	Wang Y Wang Y Ma W Lu S Chen J Cao L
author_sort	Wang Y
title	Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect
title_short	Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect
title_full	Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect
title_fullStr	Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect
title_full_unstemmed	Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect
title_sort	correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/5413fc95463a446aa2f754620232a97a
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Correlation between cognitive impairment during the acute phase of first cerebral infarction and development of long-term pseudobulbar affect

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