Abnormal brain connectivity patterns in adults with ADHD: a coherence study.

Studies based on functional magnetic resonance imaging (fMRI) during the resting state have shown decreased functional connectivity between the dorsal anterior cingulate cortex (dACC) and regions of the Default Mode Network (DMN) in adult patients with Attention-Deficit/Hyperactivity Disorder (ADHD)...

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Autores principales:	João Ricardo Sato, Marcelo Queiroz Hoexter, Xavier Francisco Castellanos, Luis A Rohde
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5418d9c6436e4ce391e2f8bf02d725b6
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spelling	oai:doaj.org-article:5418d9c6436e4ce391e2f8bf02d725b62021-11-18T08:13:55ZAbnormal brain connectivity patterns in adults with ADHD: a coherence study.1932-620310.1371/journal.pone.0045671https://doaj.org/article/5418d9c6436e4ce391e2f8bf02d725b62012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23049834/?tool=EBIhttps://doaj.org/toc/1932-6203Studies based on functional magnetic resonance imaging (fMRI) during the resting state have shown decreased functional connectivity between the dorsal anterior cingulate cortex (dACC) and regions of the Default Mode Network (DMN) in adult patients with Attention-Deficit/Hyperactivity Disorder (ADHD) relative to subjects with typical development (TD). Most studies used Pearson correlation coefficients among the BOLD signals from different brain regions to quantify functional connectivity. Since the Pearson correlation analysis only provides a limited description of functional connectivity, we investigated functional connectivity between the dACC and the posterior cingulate cortex (PCC) in three groups (adult patients with ADHD, n=21; TD age-matched subjects, n=21; young TD subjects, n=21) using a more comprehensive analytical approach - unsupervised machine learning using a one-class support vector machine (OC-SVM) that quantifies an abnormality index for each individual. The median abnormality index for patients with ADHD was greater than for TD age-matched subjects (p=0.014); the ADHD and young TD indices did not differ significantly (p=0.480); the median abnormality index of young TD was greater than that of TD age-matched subjects (p=0.016). Low frequencies below 0.05 Hz and around 0.20 Hz were the most relevant for discriminating between ADHD patients and TD age-matched controls and between the older and younger TD subjects. In addition, we validated our approach using the fMRI data of children publicly released by the ADHD-200 Competition, obtaining similar results. Our findings suggest that the abnormal coherence patterns observed in patients with ADHD in this study resemble the patterns observed in young typically developing subjects, which reinforces the hypothesis that ADHD is associated with brain maturation deficits.João Ricardo SatoMarcelo Queiroz HoexterXavier Francisco CastellanosLuis A RohdePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 9, p e45671 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q João Ricardo Sato Marcelo Queiroz Hoexter Xavier Francisco Castellanos Luis A Rohde Abnormal brain connectivity patterns in adults with ADHD: a coherence study.
description	Studies based on functional magnetic resonance imaging (fMRI) during the resting state have shown decreased functional connectivity between the dorsal anterior cingulate cortex (dACC) and regions of the Default Mode Network (DMN) in adult patients with Attention-Deficit/Hyperactivity Disorder (ADHD) relative to subjects with typical development (TD). Most studies used Pearson correlation coefficients among the BOLD signals from different brain regions to quantify functional connectivity. Since the Pearson correlation analysis only provides a limited description of functional connectivity, we investigated functional connectivity between the dACC and the posterior cingulate cortex (PCC) in three groups (adult patients with ADHD, n=21; TD age-matched subjects, n=21; young TD subjects, n=21) using a more comprehensive analytical approach - unsupervised machine learning using a one-class support vector machine (OC-SVM) that quantifies an abnormality index for each individual. The median abnormality index for patients with ADHD was greater than for TD age-matched subjects (p=0.014); the ADHD and young TD indices did not differ significantly (p=0.480); the median abnormality index of young TD was greater than that of TD age-matched subjects (p=0.016). Low frequencies below 0.05 Hz and around 0.20 Hz were the most relevant for discriminating between ADHD patients and TD age-matched controls and between the older and younger TD subjects. In addition, we validated our approach using the fMRI data of children publicly released by the ADHD-200 Competition, obtaining similar results. Our findings suggest that the abnormal coherence patterns observed in patients with ADHD in this study resemble the patterns observed in young typically developing subjects, which reinforces the hypothesis that ADHD is associated with brain maturation deficits.
format	article
author	João Ricardo Sato Marcelo Queiroz Hoexter Xavier Francisco Castellanos Luis A Rohde
author_facet	João Ricardo Sato Marcelo Queiroz Hoexter Xavier Francisco Castellanos Luis A Rohde
author_sort	João Ricardo Sato
title	Abnormal brain connectivity patterns in adults with ADHD: a coherence study.
title_short	Abnormal brain connectivity patterns in adults with ADHD: a coherence study.
title_full	Abnormal brain connectivity patterns in adults with ADHD: a coherence study.
title_fullStr	Abnormal brain connectivity patterns in adults with ADHD: a coherence study.
title_full_unstemmed	Abnormal brain connectivity patterns in adults with ADHD: a coherence study.
title_sort	abnormal brain connectivity patterns in adults with adhd: a coherence study.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/5418d9c6436e4ce391e2f8bf02d725b6
work_keys_str_mv	AT joaoricardosato abnormalbrainconnectivitypatternsinadultswithadhdacoherencestudy AT marceloqueirozhoexter abnormalbrainconnectivitypatternsinadultswithadhdacoherencestudy AT xavierfranciscocastellanos abnormalbrainconnectivitypatternsinadultswithadhdacoherencestudy AT luisarohde abnormalbrainconnectivitypatternsinadultswithadhdacoherencestudy
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Abnormal brain connectivity patterns in adults with ADHD: a coherence study.

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