A systematic review of modeling and simulation approaches in designing targeted treatment technologies for Leukemia Cancer in low and middle income countries

Virtual experimentation is a widely used approach for predicting systems behaviour especially in situations where resources for physical experiments are very limited. For example, targeted treatment inside the human body is particularly challenging, and as such, modeling and simulation is utilised t...

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Autores principales:	Henry Fenekansi Kiwumulo, Haruna Muwonge, Charles Ibingira, John Baptist Kirabira, Robert Tamale. Ssekitoleko
Formato:	article
Lenguaje:	EN
Publicado:	AIMS Press 2021
Materias:	modeling and simulation lmics leukemia treatment targeted drug delivery nanomedicine magnetic strength Biotechnology TP248.13-248.65 Mathematics QA1-939
Acceso en línea:	https://doaj.org/article/541a7fd5556d43728614f244586a9e1e
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spelling	oai:doaj.org-article:541a7fd5556d43728614f244586a9e1e2021-11-24T00:57:38ZA systematic review of modeling and simulation approaches in designing targeted treatment technologies for Leukemia Cancer in low and middle income countries10.3934/mbe.20214041551-0018https://doaj.org/article/541a7fd5556d43728614f244586a9e1e2021-09-01T00:00:00Zhttps://www.aimspress.com/article/doi/10.3934/mbe.2021404?viewType=HTMLhttps://doaj.org/toc/1551-0018Virtual experimentation is a widely used approach for predicting systems behaviour especially in situations where resources for physical experiments are very limited. For example, targeted treatment inside the human body is particularly challenging, and as such, modeling and simulation is utilised to aid planning before a specific treatment is administered. In such approaches, precise treatment, as it is the case in radiotherapy, is used to administer a maximum dose to the infected regions while minimizing the effect on normal tissue. Complicated cancers such as leukemia present even greater challenges due to their presentation in liquid form and not being localised in one area. As such, science has led to the development of targeted drug delivery, where the infected cells can be specifically targeted anywhere in the body. Despite the great prospects and advances of these modeling and simulation tools in the design and delivery of targeted drugs, their use by Low and Middle Income Countries (LMICs) researchers and clinicians is still very limited. This paper therefore reviews the modeling and simulation approaches for leukemia treatment using nanoparticles as an example for virtual experimentation. A systematic review from various databases was carried out for studies that involved cancer treatment approaches through modeling and simulation with emphasis to data collected from LMICs. Results indicated that whereas there is an increasing trend in the use of modeling and simulation approaches, their uptake in LMICs is still limited. According to the review data collected, there is a clear need to employ these tools as key approaches for the planning of targeted drug treatment approaches.Henry Fenekansi KiwumuloHaruna MuwongeCharles Ibingira John Baptist KirabiraRobert Tamale. SsekitolekoAIMS Pressarticlemodeling and simulationlmicsleukemia treatmenttargeted drug deliverynanomedicinemagnetic strengthBiotechnologyTP248.13-248.65MathematicsQA1-939ENMathematical Biosciences and Engineering, Vol 18, Iss 6, Pp 8149-8173 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	modeling and simulation lmics leukemia treatment targeted drug delivery nanomedicine magnetic strength Biotechnology TP248.13-248.65 Mathematics QA1-939
spellingShingle	modeling and simulation lmics leukemia treatment targeted drug delivery nanomedicine magnetic strength Biotechnology TP248.13-248.65 Mathematics QA1-939 Henry Fenekansi Kiwumulo Haruna Muwonge Charles Ibingira John Baptist Kirabira Robert Tamale. Ssekitoleko A systematic review of modeling and simulation approaches in designing targeted treatment technologies for Leukemia Cancer in low and middle income countries
description	Virtual experimentation is a widely used approach for predicting systems behaviour especially in situations where resources for physical experiments are very limited. For example, targeted treatment inside the human body is particularly challenging, and as such, modeling and simulation is utilised to aid planning before a specific treatment is administered. In such approaches, precise treatment, as it is the case in radiotherapy, is used to administer a maximum dose to the infected regions while minimizing the effect on normal tissue. Complicated cancers such as leukemia present even greater challenges due to their presentation in liquid form and not being localised in one area. As such, science has led to the development of targeted drug delivery, where the infected cells can be specifically targeted anywhere in the body. Despite the great prospects and advances of these modeling and simulation tools in the design and delivery of targeted drugs, their use by Low and Middle Income Countries (LMICs) researchers and clinicians is still very limited. This paper therefore reviews the modeling and simulation approaches for leukemia treatment using nanoparticles as an example for virtual experimentation. A systematic review from various databases was carried out for studies that involved cancer treatment approaches through modeling and simulation with emphasis to data collected from LMICs. Results indicated that whereas there is an increasing trend in the use of modeling and simulation approaches, their uptake in LMICs is still limited. According to the review data collected, there is a clear need to employ these tools as key approaches for the planning of targeted drug treatment approaches.
format	article
author	Henry Fenekansi Kiwumulo Haruna Muwonge Charles Ibingira John Baptist Kirabira Robert Tamale. Ssekitoleko
author_facet	Henry Fenekansi Kiwumulo Haruna Muwonge Charles Ibingira John Baptist Kirabira Robert Tamale. Ssekitoleko
author_sort	Henry Fenekansi Kiwumulo
title	A systematic review of modeling and simulation approaches in designing targeted treatment technologies for Leukemia Cancer in low and middle income countries
title_short	A systematic review of modeling and simulation approaches in designing targeted treatment technologies for Leukemia Cancer in low and middle income countries
title_full	A systematic review of modeling and simulation approaches in designing targeted treatment technologies for Leukemia Cancer in low and middle income countries
title_fullStr	A systematic review of modeling and simulation approaches in designing targeted treatment technologies for Leukemia Cancer in low and middle income countries
title_full_unstemmed	A systematic review of modeling and simulation approaches in designing targeted treatment technologies for Leukemia Cancer in low and middle income countries
title_sort	systematic review of modeling and simulation approaches in designing targeted treatment technologies for leukemia cancer in low and middle income countries
publisher	AIMS Press
publishDate	2021
url	https://doaj.org/article/541a7fd5556d43728614f244586a9e1e
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A systematic review of modeling and simulation approaches in designing targeted treatment technologies for Leukemia Cancer in low and middle income countries

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