DNA damage checkpoint and repair: From the budding yeast Saccharomyces cerevisiae to the pathogenic fungus Candida albicans

Cells are constantly challenged by internal or external genotoxic assaults, which may induce a high frequency of DNA lesions, leading to genome instability. Accumulation of damaged DNA is severe or even lethal to cells and can result in abnormal proliferation that can cause cancer in multicellular o...

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Autores principales:	Shuangyan Yao, Yuting Feng, Yan Zhang, Jinrong Feng
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	DNA damage response DNA damage checkpoint DNA damage repair Candida albicans Pathogenicity Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/541f12c6e8e6440d9629da705c28f370
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spelling	oai:doaj.org-article:541f12c6e8e6440d9629da705c28f3702021-12-04T04:33:34ZDNA damage checkpoint and repair: From the budding yeast Saccharomyces cerevisiae to the pathogenic fungus Candida albicans2001-037010.1016/j.csbj.2021.11.033https://doaj.org/article/541f12c6e8e6440d9629da705c28f3702021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2001037021004980https://doaj.org/toc/2001-0370Cells are constantly challenged by internal or external genotoxic assaults, which may induce a high frequency of DNA lesions, leading to genome instability. Accumulation of damaged DNA is severe or even lethal to cells and can result in abnormal proliferation that can cause cancer in multicellular organisms, aging or cell death. Eukaryotic cells have evolved a comprehensive defence system termed the DNA damage response (DDR) to monitor and remove lesions in their DNA. The DDR has been extensively studied in the budding yeast Saccharomyces cerevisiae. Emerging evidence indicates that DDR genes in the pathogenic fungus Candida albicans show functional consistency with their orthologs in S. cerevisiae, but may act through distinct mechanisms. In particular, the DDR in C. albicans appears critical for resisting DNA damage stress induced by reactive oxygen species (ROS) produced from immune cells, and this plays a vital role in pathogenicity. Therefore, DDR genes could be considered as potential targets for clinical therapies. This review summarizes the identified DNA damage checkpoint and repair genes in C. albicans based on their orthologs in S. cerevisiae, and discusses their contribution to pathogenicity in C. albicans.Shuangyan YaoYuting FengYan ZhangJinrong FengElsevierarticleDNA damage responseDNA damage checkpointDNA damage repairCandida albicansPathogenicityBiotechnologyTP248.13-248.65ENComputational and Structural Biotechnology Journal, Vol 19, Iss , Pp 6343-6354 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DNA damage response DNA damage checkpoint DNA damage repair Candida albicans Pathogenicity Biotechnology TP248.13-248.65
spellingShingle	DNA damage response DNA damage checkpoint DNA damage repair Candida albicans Pathogenicity Biotechnology TP248.13-248.65 Shuangyan Yao Yuting Feng Yan Zhang Jinrong Feng DNA damage checkpoint and repair: From the budding yeast Saccharomyces cerevisiae to the pathogenic fungus Candida albicans
description	Cells are constantly challenged by internal or external genotoxic assaults, which may induce a high frequency of DNA lesions, leading to genome instability. Accumulation of damaged DNA is severe or even lethal to cells and can result in abnormal proliferation that can cause cancer in multicellular organisms, aging or cell death. Eukaryotic cells have evolved a comprehensive defence system termed the DNA damage response (DDR) to monitor and remove lesions in their DNA. The DDR has been extensively studied in the budding yeast Saccharomyces cerevisiae. Emerging evidence indicates that DDR genes in the pathogenic fungus Candida albicans show functional consistency with their orthologs in S. cerevisiae, but may act through distinct mechanisms. In particular, the DDR in C. albicans appears critical for resisting DNA damage stress induced by reactive oxygen species (ROS) produced from immune cells, and this plays a vital role in pathogenicity. Therefore, DDR genes could be considered as potential targets for clinical therapies. This review summarizes the identified DNA damage checkpoint and repair genes in C. albicans based on their orthologs in S. cerevisiae, and discusses their contribution to pathogenicity in C. albicans.
format	article
author	Shuangyan Yao Yuting Feng Yan Zhang Jinrong Feng
author_facet	Shuangyan Yao Yuting Feng Yan Zhang Jinrong Feng
author_sort	Shuangyan Yao
title	DNA damage checkpoint and repair: From the budding yeast Saccharomyces cerevisiae to the pathogenic fungus Candida albicans
title_short	DNA damage checkpoint and repair: From the budding yeast Saccharomyces cerevisiae to the pathogenic fungus Candida albicans
title_full	DNA damage checkpoint and repair: From the budding yeast Saccharomyces cerevisiae to the pathogenic fungus Candida albicans
title_fullStr	DNA damage checkpoint and repair: From the budding yeast Saccharomyces cerevisiae to the pathogenic fungus Candida albicans
title_full_unstemmed	DNA damage checkpoint and repair: From the budding yeast Saccharomyces cerevisiae to the pathogenic fungus Candida albicans
title_sort	dna damage checkpoint and repair: from the budding yeast saccharomyces cerevisiae to the pathogenic fungus candida albicans
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/541f12c6e8e6440d9629da705c28f370
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DNA damage checkpoint and repair: From the budding yeast Saccharomyces cerevisiae to the pathogenic fungus Candida albicans

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