STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

Mitophagy plays a critical role in cellular homeostasis, and PINK1/Parkin-mediated mitophagy is the most thoroughly characterized. Here, Xian et al. show that STX17 induces mitophagy via a macroautophagy pathway regulated by Fis1, by a PINK1/Parkin-independent route.

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Autores principales:	Hongxu Xian, Qiaoyun Yang, Lin Xiao, Han-Ming Shen, Yih-Cherng Liou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/541fac42676e41b1a63f6626d9812ae1
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spelling	oai:doaj.org-article:541fac42676e41b1a63f6626d9812ae12021-12-02T14:35:50ZSTX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism10.1038/s41467-019-10096-12041-1723https://doaj.org/article/541fac42676e41b1a63f6626d9812ae12019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10096-1https://doaj.org/toc/2041-1723Mitophagy plays a critical role in cellular homeostasis, and PINK1/Parkin-mediated mitophagy is the most thoroughly characterized. Here, Xian et al. show that STX17 induces mitophagy via a macroautophagy pathway regulated by Fis1, by a PINK1/Parkin-independent route.Hongxu XianQiaoyun YangLin XiaoHan-Ming ShenYih-Cherng LiouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongxu Xian Qiaoyun Yang Lin Xiao Han-Ming Shen Yih-Cherng Liou STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism
description	Mitophagy plays a critical role in cellular homeostasis, and PINK1/Parkin-mediated mitophagy is the most thoroughly characterized. Here, Xian et al. show that STX17 induces mitophagy via a macroautophagy pathway regulated by Fis1, by a PINK1/Parkin-independent route.
format	article
author	Hongxu Xian Qiaoyun Yang Lin Xiao Han-Ming Shen Yih-Cherng Liou
author_facet	Hongxu Xian Qiaoyun Yang Lin Xiao Han-Ming Shen Yih-Cherng Liou
author_sort	Hongxu Xian
title	STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism
title_short	STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism
title_full	STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism
title_fullStr	STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism
title_full_unstemmed	STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism
title_sort	stx17 dynamically regulated by fis1 induces mitophagy via hierarchical macroautophagic mechanism
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/541fac42676e41b1a63f6626d9812ae1
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STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism

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