Association of SNPs of CD40 gene with multiple sclerosis in Russians.
Multiple sclerosis (MS) is a serious, incurable neurological disease. In 2009, the ANZgene studies detected the suggestive association of located upstream of CD40 gene in chromosome 20q13 (p = 1.3×10(-7)). Identification of the causal variant(s) in the CD40 locus leads to a better understanding of t...
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oai:doaj.org-article:5420b759ae6745f08f4391af5e65c07c2021-11-18T07:48:38ZAssociation of SNPs of CD40 gene with multiple sclerosis in Russians.1932-620310.1371/journal.pone.0061032https://doaj.org/article/5420b759ae6745f08f4391af5e65c07c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23613777/?tool=EBIhttps://doaj.org/toc/1932-6203Multiple sclerosis (MS) is a serious, incurable neurological disease. In 2009, the ANZgene studies detected the suggestive association of located upstream of CD40 gene in chromosome 20q13 (p = 1.3×10(-7)). Identification of the causal variant(s) in the CD40 locus leads to a better understanding of the mechanism underlying the development of autoimmune pathologies. We determined the genotypes of rs6074022, rs1883832, rs1535045, and rs11086996 in patients with MS (n = 1684) and in the control group (n = 879). Two SNPs were significantly associated with MS: rs6074022 (additive model C allele OR = 1.27, 95% CI = [1.12-1.45], p = 3×10(-4)) and rs1883832 (additive model T allele OR = 1.20, 95% CI = [1.05-1.38], p = 7×10(-3)). In the meta-analysis of our results and the results of four previous studies, we obtain the association p-value of 2.34×10(-12), which confirmed the association between MS and rs6074022 at a genome-wide significant level. Next, we demonstrated that the model including rs6074022 only sufficiently described the association. From our analysis, we can speculate that the association between rs1883832 and MS was induced by LD, whereas rs6074022 was a marker in stronger LD with the functional variant or was the functional variant itself. Our results indicated that the functional variants were located in the upstream region of the gene CD40 and were in higher LD with rs6074022 than LD with rs1883832.Ekaterina Alekseevna SokolovaNadezhda Alekseevna MalkovaDenis Sergeevich KorobkoAleksey Sergeevich RozhdestvenskiiAnastasia Vladimirovna KakulyaElena Vladimirovna KhanokhRoman Andreevich DelovFedor Alekseevich PlatonovTatyana Yegorovna PopovaElena Gennadievna Aref' evaNatalia Nikolaevna ZagorskayaValentina Mikhailovna AlifirovaMarina Andreevna TitovaInna Vadimovna SmaginaSvetlana Alksandrovna El' chaninovaAnna Valentinovna PopovtsevaValery Pavlovich PuzyrevOlga Georgievna KulakovaEkaterina Yur'evna TsarevaOlga Olegovna FavorovaSergei Gennadievich ShchurNatalia Yurievna LashchNatalia Fyodorovna PopovaEkaterina Valerievna PopovaEvgenii Ivanovich GusevAleksey Nikolaevich BoykoYurii Sergeevich AulchenkoMaxim Leonidovich FilipenkoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e61032 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Ekaterina Alekseevna Sokolova Nadezhda Alekseevna Malkova Denis Sergeevich Korobko Aleksey Sergeevich Rozhdestvenskii Anastasia Vladimirovna Kakulya Elena Vladimirovna Khanokh Roman Andreevich Delov Fedor Alekseevich Platonov Tatyana Yegorovna Popova Elena Gennadievna Aref' eva Natalia Nikolaevna Zagorskaya Valentina Mikhailovna Alifirova Marina Andreevna Titova Inna Vadimovna Smagina Svetlana Alksandrovna El' chaninova Anna Valentinovna Popovtseva Valery Pavlovich Puzyrev Olga Georgievna Kulakova Ekaterina Yur'evna Tsareva Olga Olegovna Favorova Sergei Gennadievich Shchur Natalia Yurievna Lashch Natalia Fyodorovna Popova Ekaterina Valerievna Popova Evgenii Ivanovich Gusev Aleksey Nikolaevich Boyko Yurii Sergeevich Aulchenko Maxim Leonidovich Filipenko Association of SNPs of CD40 gene with multiple sclerosis in Russians. |
| description |
Multiple sclerosis (MS) is a serious, incurable neurological disease. In 2009, the ANZgene studies detected the suggestive association of located upstream of CD40 gene in chromosome 20q13 (p = 1.3×10(-7)). Identification of the causal variant(s) in the CD40 locus leads to a better understanding of the mechanism underlying the development of autoimmune pathologies. We determined the genotypes of rs6074022, rs1883832, rs1535045, and rs11086996 in patients with MS (n = 1684) and in the control group (n = 879). Two SNPs were significantly associated with MS: rs6074022 (additive model C allele OR = 1.27, 95% CI = [1.12-1.45], p = 3×10(-4)) and rs1883832 (additive model T allele OR = 1.20, 95% CI = [1.05-1.38], p = 7×10(-3)). In the meta-analysis of our results and the results of four previous studies, we obtain the association p-value of 2.34×10(-12), which confirmed the association between MS and rs6074022 at a genome-wide significant level. Next, we demonstrated that the model including rs6074022 only sufficiently described the association. From our analysis, we can speculate that the association between rs1883832 and MS was induced by LD, whereas rs6074022 was a marker in stronger LD with the functional variant or was the functional variant itself. Our results indicated that the functional variants were located in the upstream region of the gene CD40 and were in higher LD with rs6074022 than LD with rs1883832. |
| format |
article |
| author |
Ekaterina Alekseevna Sokolova Nadezhda Alekseevna Malkova Denis Sergeevich Korobko Aleksey Sergeevich Rozhdestvenskii Anastasia Vladimirovna Kakulya Elena Vladimirovna Khanokh Roman Andreevich Delov Fedor Alekseevich Platonov Tatyana Yegorovna Popova Elena Gennadievna Aref' eva Natalia Nikolaevna Zagorskaya Valentina Mikhailovna Alifirova Marina Andreevna Titova Inna Vadimovna Smagina Svetlana Alksandrovna El' chaninova Anna Valentinovna Popovtseva Valery Pavlovich Puzyrev Olga Georgievna Kulakova Ekaterina Yur'evna Tsareva Olga Olegovna Favorova Sergei Gennadievich Shchur Natalia Yurievna Lashch Natalia Fyodorovna Popova Ekaterina Valerievna Popova Evgenii Ivanovich Gusev Aleksey Nikolaevich Boyko Yurii Sergeevich Aulchenko Maxim Leonidovich Filipenko |
| author_facet |
Ekaterina Alekseevna Sokolova Nadezhda Alekseevna Malkova Denis Sergeevich Korobko Aleksey Sergeevich Rozhdestvenskii Anastasia Vladimirovna Kakulya Elena Vladimirovna Khanokh Roman Andreevich Delov Fedor Alekseevich Platonov Tatyana Yegorovna Popova Elena Gennadievna Aref' eva Natalia Nikolaevna Zagorskaya Valentina Mikhailovna Alifirova Marina Andreevna Titova Inna Vadimovna Smagina Svetlana Alksandrovna El' chaninova Anna Valentinovna Popovtseva Valery Pavlovich Puzyrev Olga Georgievna Kulakova Ekaterina Yur'evna Tsareva Olga Olegovna Favorova Sergei Gennadievich Shchur Natalia Yurievna Lashch Natalia Fyodorovna Popova Ekaterina Valerievna Popova Evgenii Ivanovich Gusev Aleksey Nikolaevich Boyko Yurii Sergeevich Aulchenko Maxim Leonidovich Filipenko |
| author_sort |
Ekaterina Alekseevna Sokolova |
| title |
Association of SNPs of CD40 gene with multiple sclerosis in Russians. |
| title_short |
Association of SNPs of CD40 gene with multiple sclerosis in Russians. |
| title_full |
Association of SNPs of CD40 gene with multiple sclerosis in Russians. |
| title_fullStr |
Association of SNPs of CD40 gene with multiple sclerosis in Russians. |
| title_full_unstemmed |
Association of SNPs of CD40 gene with multiple sclerosis in Russians. |
| title_sort |
association of snps of cd40 gene with multiple sclerosis in russians. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/5420b759ae6745f08f4391af5e65c07c |
| work_keys_str_mv |
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