Eight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in Parkinson’s disease

Abstract This study compares the effects on motor symptoms between conventional deep brain stimulation (cDBS) and closed-loop adaptive deep brain stimulation (aDBS) in patients with Parkinson’s Disease. The aDBS stimulation is controlled by the power in the beta band (12–35 Hz) of local field potent...

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Autores principales:	Tommaso Bocci, Marco Prenassi, Mattia Arlotti, Filippo Maria Cogiamanian, Linda Borrellini, Elena Moro, Andres M. Lozano, Jens Volkmann, Sergio Barbieri, Alberto Priori, Sara Marceglia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/542ad4be22b04841b8f1c1e2dfd1e559
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spelling	oai:doaj.org-article:542ad4be22b04841b8f1c1e2dfd1e5592021-12-02T17:18:23ZEight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in Parkinson’s disease10.1038/s41531-021-00229-z2373-8057https://doaj.org/article/542ad4be22b04841b8f1c1e2dfd1e5592021-09-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00229-zhttps://doaj.org/toc/2373-8057Abstract This study compares the effects on motor symptoms between conventional deep brain stimulation (cDBS) and closed-loop adaptive deep brain stimulation (aDBS) in patients with Parkinson’s Disease. The aDBS stimulation is controlled by the power in the beta band (12–35 Hz) of local field potentials recorded directly by subthalamic nucleus electrodes. Eight subjects were assessed in two 8-h stimulation sessions (first day, cDBS; second day, aDBS) with regular levodopa intake and during normal daily activities. The Unified Parkinson’s Disease Rating Scale (UPDRS) part III scores, the Rush scale for dyskinesias, and the total electrical energy delivered to the tissues per second (TEEDs) were significantly lower in the aDBS session (relative UPDRS mean, cDBS: 0.46 ± 0.05, aDBS: 0.33 ± 0.04, p = 0.015; UPDRS part III rigidity subset mean, cDBS: 2.9143 ± 0.6551 and aDBS: 2.1429 ± 0.5010, p = 0.034; UPDRS part III standard deviation cDBS: 2.95, aDBS: 2.68; p = 0.047; Rush scale, cDBS 2.79 ± 0.39 versus aDBS 1.57 ± 0.23, p = 0.037; cDBS TEEDs mean: 28.75 ± 3.36 µj s−1, aDBS TEEDs mean: 16.47 ± 3.33, p = 0.032 Wilcoxon’s sign rank test). This work further supports the safety and effectiveness of aDBS stimulation compared to cDBS in a daily session, both in terms of motor performance and TEED to the patient.Tommaso BocciMarco PrenassiMattia ArlottiFilippo Maria CogiamanianLinda BorrelliniElena MoroAndres M. LozanoJens VolkmannSergio BarbieriAlberto PrioriSara MarcegliaNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 Tommaso Bocci Marco Prenassi Mattia Arlotti Filippo Maria Cogiamanian Linda Borrellini Elena Moro Andres M. Lozano Jens Volkmann Sergio Barbieri Alberto Priori Sara Marceglia Eight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in Parkinson’s disease
description	Abstract This study compares the effects on motor symptoms between conventional deep brain stimulation (cDBS) and closed-loop adaptive deep brain stimulation (aDBS) in patients with Parkinson’s Disease. The aDBS stimulation is controlled by the power in the beta band (12–35 Hz) of local field potentials recorded directly by subthalamic nucleus electrodes. Eight subjects were assessed in two 8-h stimulation sessions (first day, cDBS; second day, aDBS) with regular levodopa intake and during normal daily activities. The Unified Parkinson’s Disease Rating Scale (UPDRS) part III scores, the Rush scale for dyskinesias, and the total electrical energy delivered to the tissues per second (TEEDs) were significantly lower in the aDBS session (relative UPDRS mean, cDBS: 0.46 ± 0.05, aDBS: 0.33 ± 0.04, p = 0.015; UPDRS part III rigidity subset mean, cDBS: 2.9143 ± 0.6551 and aDBS: 2.1429 ± 0.5010, p = 0.034; UPDRS part III standard deviation cDBS: 2.95, aDBS: 2.68; p = 0.047; Rush scale, cDBS 2.79 ± 0.39 versus aDBS 1.57 ± 0.23, p = 0.037; cDBS TEEDs mean: 28.75 ± 3.36 µj s−1, aDBS TEEDs mean: 16.47 ± 3.33, p = 0.032 Wilcoxon’s sign rank test). This work further supports the safety and effectiveness of aDBS stimulation compared to cDBS in a daily session, both in terms of motor performance and TEED to the patient.
format	article
author	Tommaso Bocci Marco Prenassi Mattia Arlotti Filippo Maria Cogiamanian Linda Borrellini Elena Moro Andres M. Lozano Jens Volkmann Sergio Barbieri Alberto Priori Sara Marceglia
author_facet	Tommaso Bocci Marco Prenassi Mattia Arlotti Filippo Maria Cogiamanian Linda Borrellini Elena Moro Andres M. Lozano Jens Volkmann Sergio Barbieri Alberto Priori Sara Marceglia
author_sort	Tommaso Bocci
title	Eight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in Parkinson’s disease
title_short	Eight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in Parkinson’s disease
title_full	Eight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in Parkinson’s disease
title_fullStr	Eight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in Parkinson’s disease
title_full_unstemmed	Eight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in Parkinson’s disease
title_sort	eight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in parkinson’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/542ad4be22b04841b8f1c1e2dfd1e559
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Eight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in Parkinson’s disease

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