Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas

Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas

Adenomyoepithelioma is a rare tumor of the breast with an unknown genetic basis. Here the authors perform a genomic analysis of adenomyoepitheliomas revealing that their repertoire of somatic mutations vary according to the estrogen receptor (ER) status, and that ER-negative tumors harbor recurrent...

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Autores principales: Felipe C. Geyer, Anqi Li, Anastasios D. Papanastasiou, Alison Smith, Pier Selenica, Kathleen A. Burke, Marcia Edelweiss, Huei-Chi Wen, Salvatore Piscuoglio, Anne M. Schultheis, Luciano G. Martelotto, Fresia Pareja, Rahul Kumar, Alissa Brandes, Dan Fan, Thais Basili, Arnaud Da Cruz Paula, John R. Lozada, Pedro Blecua, Simone Muenst, Achim A. Jungbluth, Maria P. Foschini, Hannah Y. Wen, Edi Brogi, Juan Palazzo, Brian P. Rubin, Charlotte K. Y. Ng, Larry Norton, Zsuzsanna Varga, Ian O. Ellis, Emad A. Rakha, Sarat Chandarlapaty, Britta Weigelt, Jorge S. Reis-Filho
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/542cf17a65664524a59e8d4c4c40fa5e
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spelling oai:doaj.org-article:542cf17a65664524a59e8d4c4c40fa5e2021-12-02T17:31:44ZRecurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas10.1038/s41467-018-04128-52041-1723https://doaj.org/article/542cf17a65664524a59e8d4c4c40fa5e2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04128-5https://doaj.org/toc/2041-1723Adenomyoepithelioma is a rare tumor of the breast with an unknown genetic basis. Here the authors perform a genomic analysis of adenomyoepitheliomas revealing that their repertoire of somatic mutations vary according to the estrogen receptor (ER) status, and that ER-negative tumors harbor recurrent mutations in HRAS and PI3K pathway genes.Felipe C. GeyerAnqi LiAnastasios D. PapanastasiouAlison SmithPier SelenicaKathleen A. BurkeMarcia EdelweissHuei-Chi WenSalvatore PiscuoglioAnne M. SchultheisLuciano G. MartelottoFresia ParejaRahul KumarAlissa BrandesDan FanThais BasiliArnaud Da Cruz PaulaJohn R. LozadaPedro BlecuaSimone MuenstAchim A. JungbluthMaria P. FoschiniHannah Y. WenEdi BrogiJuan PalazzoBrian P. RubinCharlotte K. Y. NgLarry NortonZsuzsanna VargaIan O. EllisEmad A. RakhaSarat ChandarlapatyBritta WeigeltJorge S. Reis-FilhoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Felipe C. Geyer
Anqi Li
Anastasios D. Papanastasiou
Alison Smith
Pier Selenica
Kathleen A. Burke
Marcia Edelweiss
Huei-Chi Wen
Salvatore Piscuoglio
Anne M. Schultheis
Luciano G. Martelotto
Fresia Pareja
Rahul Kumar
Alissa Brandes
Dan Fan
Thais Basili
Arnaud Da Cruz Paula
John R. Lozada
Pedro Blecua
Simone Muenst
Achim A. Jungbluth
Maria P. Foschini
Hannah Y. Wen
Edi Brogi
Juan Palazzo
Brian P. Rubin
Charlotte K. Y. Ng
Larry Norton
Zsuzsanna Varga
Ian O. Ellis
Emad A. Rakha
Sarat Chandarlapaty
Britta Weigelt
Jorge S. Reis-Filho
Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas
description Adenomyoepithelioma is a rare tumor of the breast with an unknown genetic basis. Here the authors perform a genomic analysis of adenomyoepitheliomas revealing that their repertoire of somatic mutations vary according to the estrogen receptor (ER) status, and that ER-negative tumors harbor recurrent mutations in HRAS and PI3K pathway genes.
format article
author Felipe C. Geyer
Anqi Li
Anastasios D. Papanastasiou
Alison Smith
Pier Selenica
Kathleen A. Burke
Marcia Edelweiss
Huei-Chi Wen
Salvatore Piscuoglio
Anne M. Schultheis
Luciano G. Martelotto
Fresia Pareja
Rahul Kumar
Alissa Brandes
Dan Fan
Thais Basili
Arnaud Da Cruz Paula
John R. Lozada
Pedro Blecua
Simone Muenst
Achim A. Jungbluth
Maria P. Foschini
Hannah Y. Wen
Edi Brogi
Juan Palazzo
Brian P. Rubin
Charlotte K. Y. Ng
Larry Norton
Zsuzsanna Varga
Ian O. Ellis
Emad A. Rakha
Sarat Chandarlapaty
Britta Weigelt
Jorge S. Reis-Filho
author_facet Felipe C. Geyer
Anqi Li
Anastasios D. Papanastasiou
Alison Smith
Pier Selenica
Kathleen A. Burke
Marcia Edelweiss
Huei-Chi Wen
Salvatore Piscuoglio
Anne M. Schultheis
Luciano G. Martelotto
Fresia Pareja
Rahul Kumar
Alissa Brandes
Dan Fan
Thais Basili
Arnaud Da Cruz Paula
John R. Lozada
Pedro Blecua
Simone Muenst
Achim A. Jungbluth
Maria P. Foschini
Hannah Y. Wen
Edi Brogi
Juan Palazzo
Brian P. Rubin
Charlotte K. Y. Ng
Larry Norton
Zsuzsanna Varga
Ian O. Ellis
Emad A. Rakha
Sarat Chandarlapaty
Britta Weigelt
Jorge S. Reis-Filho
author_sort Felipe C. Geyer
title Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas
title_short Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas
title_full Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas
title_fullStr Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas
title_full_unstemmed Recurrent hotspot mutations in HRAS Q61 and PI3K-AKT pathway genes as drivers of breast adenomyoepitheliomas
title_sort recurrent hotspot mutations in hras q61 and pi3k-akt pathway genes as drivers of breast adenomyoepitheliomas
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/542cf17a65664524a59e8d4c4c40fa5e
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