Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion

Abstract Melanoma is a highly aggressive cancer that exhibits metastasis to various critical organs. Unlike any other cancer cells, melanoma cells can synthesize melanin in large amounts, becoming heavily pigmented. Until now the role of melanin in melanoma, particularly the effect of melanin presen...

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Autores principales:	Michal Sarna, Martyna Krzykawska-Serda, Monika Jakubowska, Andrzej Zadlo, Krystyna Urbanska
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/542ffe84436442928fd0976caeef0904
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spelling	oai:doaj.org-article:542ffe84436442928fd0976caeef09042021-12-02T15:09:38ZMelanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion10.1038/s41598-019-45643-92045-2322https://doaj.org/article/542ffe84436442928fd0976caeef09042019-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-45643-9https://doaj.org/toc/2045-2322Abstract Melanoma is a highly aggressive cancer that exhibits metastasis to various critical organs. Unlike any other cancer cells, melanoma cells can synthesize melanin in large amounts, becoming heavily pigmented. Until now the role of melanin in melanoma, particularly the effect of melanin presence on the abilities of melanoma cells to spread and metastasize remains unknown. Recently, we have shown that melanin dramatically modified elastic properties of melanoma cells and inhibited the cells invasive abilities in vitro. Here, we inoculated human melanoma cells with different melanin content into nude mice and tested the hypothesis that cell elasticity is an important property of cancer cells for their efficient spread in vivo. The obtained results clearly showed that cells containing melanin were less capable to spread in mice than cells without the pigment. Our findings indicate that the presence of melanin inhibits melanoma metastasis, emphasizing possible clinical implications of such an inhibitory effect.Michal SarnaMartyna Krzykawska-SerdaMonika JakubowskaAndrzej ZadloKrystyna UrbanskaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michal Sarna Martyna Krzykawska-Serda Monika Jakubowska Andrzej Zadlo Krystyna Urbanska Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion
description	Abstract Melanoma is a highly aggressive cancer that exhibits metastasis to various critical organs. Unlike any other cancer cells, melanoma cells can synthesize melanin in large amounts, becoming heavily pigmented. Until now the role of melanin in melanoma, particularly the effect of melanin presence on the abilities of melanoma cells to spread and metastasize remains unknown. Recently, we have shown that melanin dramatically modified elastic properties of melanoma cells and inhibited the cells invasive abilities in vitro. Here, we inoculated human melanoma cells with different melanin content into nude mice and tested the hypothesis that cell elasticity is an important property of cancer cells for their efficient spread in vivo. The obtained results clearly showed that cells containing melanin were less capable to spread in mice than cells without the pigment. Our findings indicate that the presence of melanin inhibits melanoma metastasis, emphasizing possible clinical implications of such an inhibitory effect.
format	article
author	Michal Sarna Martyna Krzykawska-Serda Monika Jakubowska Andrzej Zadlo Krystyna Urbanska
author_facet	Michal Sarna Martyna Krzykawska-Serda Monika Jakubowska Andrzej Zadlo Krystyna Urbanska
author_sort	Michal Sarna
title	Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion
title_short	Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion
title_full	Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion
title_fullStr	Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion
title_full_unstemmed	Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion
title_sort	melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/542ffe84436442928fd0976caeef0904
work_keys_str_mv	AT michalsarna melaninpresenceinhibitsmelanomacellspreadinmiceinauniquemechanicalfashion AT martynakrzykawskaserda melaninpresenceinhibitsmelanomacellspreadinmiceinauniquemechanicalfashion AT monikajakubowska melaninpresenceinhibitsmelanomacellspreadinmiceinauniquemechanicalfashion AT andrzejzadlo melaninpresenceinhibitsmelanomacellspreadinmiceinauniquemechanicalfashion AT krystynaurbanska melaninpresenceinhibitsmelanomacellspreadinmiceinauniquemechanicalfashion
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Melanin presence inhibits melanoma cell spread in mice in a unique mechanical fashion

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