Dental health assessed using panoramic radiograph and adverse events in chronic kidney disease stage 4-5 patients transitioning to dialysis and transplantation-A prospective cohort study.

<h4>Background and aims</h4>Oral health could potentially be a modifiable risk factor for adverse outcomes in chronic kidney disease (CKD) patients transitioning from predialysis treatment to maintenance dialysis and transplantation. We aimed to study the association between an index of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mikko J Järvisalo, Viljami Jokihaka, Markus Hakamäki, Roosa Lankinen, Heidi Helin, Niina S Koivuviita, Tapio Hellman, Kaj Metsärinne
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/54334d5c2ab649ad9b971e206380655f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:54334d5c2ab649ad9b971e206380655f
record_format	dspace
spelling	oai:doaj.org-article:54334d5c2ab649ad9b971e206380655f2021-12-02T20:13:53ZDental health assessed using panoramic radiograph and adverse events in chronic kidney disease stage 4-5 patients transitioning to dialysis and transplantation-A prospective cohort study.1932-620310.1371/journal.pone.0258055https://doaj.org/article/54334d5c2ab649ad9b971e206380655f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258055https://doaj.org/toc/1932-6203<h4>Background and aims</h4>Oral health could potentially be a modifiable risk factor for adverse outcomes in chronic kidney disease (CKD) patients transitioning from predialysis treatment to maintenance dialysis and transplantation. We aimed to study the association between an index of radiographically assessed oral health, Panoramic Tomographic Index (PTI), and cardiovascular and all-cause mortality, major adverse cardiovascular events (MACEs) and episodes of bacteremia and laboratory measurements during a three-year prospective follow-up in CKD stage 4-5 patients not on maintenance dialysis at baseline.<h4>Methods</h4>Altogether 190 CKD stage 4-5 patients without maintenance dialysis attended panoramic dental radiographs in the beginning of the study. The patients were followed up for three years or until death. MACEs and episodes of bacteremia were recorded during follow-up. Laboratory sampling for C-reactive protein and leukocytes was repeated tri-monthly.<h4>Results</h4>PTI was not associated with baseline laboratory parameters or C-reactive protein or leukocytes examined as repeated measures through the 3-year follow-up. During follow-up, 22 patients had at least one episode of bacteremia, but only 2 of the bacteremias were considered to be of oral origin. PTI was not associated with incident bacteremia during follow-up. Thirty-six patients died during follow-up including 17 patients due to cardiovascular causes. During follow-up 42 patients were observed with a MACE. PTI was independently associated with all-cause (HR 1.074 95% CI 1.029-1.122, p = 0.001) and cardiovascular (HR 1.105, 95% CI 1.057-1.157, p<0.0001) mortality, as well as, incident MACEs (HR 1.071 95% CI 1.031-1.113, p = 0.0004) in the multivariable Cox models adjusted for age and kidney transplantation or CKD treatment modality during follow-up.<h4>Conclusions</h4>Radiographically assessed dental health is independently associated with all-cause and cardiovascular mortality and MACEs but not with the incidence of bacteremia in CKD stage 4-5 patients transitioning to maintenance dialysis and renal transplantation during follow-up.Mikko J JärvisaloViljami JokihakaMarkus HakamäkiRoosa LankinenHeidi HelinNiina S KoivuviitaTapio HellmanKaj MetsärinnePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0258055 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mikko J Järvisalo Viljami Jokihaka Markus Hakamäki Roosa Lankinen Heidi Helin Niina S Koivuviita Tapio Hellman Kaj Metsärinne Dental health assessed using panoramic radiograph and adverse events in chronic kidney disease stage 4-5 patients transitioning to dialysis and transplantation-A prospective cohort study.
description	<h4>Background and aims</h4>Oral health could potentially be a modifiable risk factor for adverse outcomes in chronic kidney disease (CKD) patients transitioning from predialysis treatment to maintenance dialysis and transplantation. We aimed to study the association between an index of radiographically assessed oral health, Panoramic Tomographic Index (PTI), and cardiovascular and all-cause mortality, major adverse cardiovascular events (MACEs) and episodes of bacteremia and laboratory measurements during a three-year prospective follow-up in CKD stage 4-5 patients not on maintenance dialysis at baseline.<h4>Methods</h4>Altogether 190 CKD stage 4-5 patients without maintenance dialysis attended panoramic dental radiographs in the beginning of the study. The patients were followed up for three years or until death. MACEs and episodes of bacteremia were recorded during follow-up. Laboratory sampling for C-reactive protein and leukocytes was repeated tri-monthly.<h4>Results</h4>PTI was not associated with baseline laboratory parameters or C-reactive protein or leukocytes examined as repeated measures through the 3-year follow-up. During follow-up, 22 patients had at least one episode of bacteremia, but only 2 of the bacteremias were considered to be of oral origin. PTI was not associated with incident bacteremia during follow-up. Thirty-six patients died during follow-up including 17 patients due to cardiovascular causes. During follow-up 42 patients were observed with a MACE. PTI was independently associated with all-cause (HR 1.074 95% CI 1.029-1.122, p = 0.001) and cardiovascular (HR 1.105, 95% CI 1.057-1.157, p<0.0001) mortality, as well as, incident MACEs (HR 1.071 95% CI 1.031-1.113, p = 0.0004) in the multivariable Cox models adjusted for age and kidney transplantation or CKD treatment modality during follow-up.<h4>Conclusions</h4>Radiographically assessed dental health is independently associated with all-cause and cardiovascular mortality and MACEs but not with the incidence of bacteremia in CKD stage 4-5 patients transitioning to maintenance dialysis and renal transplantation during follow-up.
format	article
author	Mikko J Järvisalo Viljami Jokihaka Markus Hakamäki Roosa Lankinen Heidi Helin Niina S Koivuviita Tapio Hellman Kaj Metsärinne
author_facet	Mikko J Järvisalo Viljami Jokihaka Markus Hakamäki Roosa Lankinen Heidi Helin Niina S Koivuviita Tapio Hellman Kaj Metsärinne
author_sort	Mikko J Järvisalo
title	Dental health assessed using panoramic radiograph and adverse events in chronic kidney disease stage 4-5 patients transitioning to dialysis and transplantation-A prospective cohort study.
title_short	Dental health assessed using panoramic radiograph and adverse events in chronic kidney disease stage 4-5 patients transitioning to dialysis and transplantation-A prospective cohort study.
title_full	Dental health assessed using panoramic radiograph and adverse events in chronic kidney disease stage 4-5 patients transitioning to dialysis and transplantation-A prospective cohort study.
title_fullStr	Dental health assessed using panoramic radiograph and adverse events in chronic kidney disease stage 4-5 patients transitioning to dialysis and transplantation-A prospective cohort study.
title_full_unstemmed	Dental health assessed using panoramic radiograph and adverse events in chronic kidney disease stage 4-5 patients transitioning to dialysis and transplantation-A prospective cohort study.
title_sort	dental health assessed using panoramic radiograph and adverse events in chronic kidney disease stage 4-5 patients transitioning to dialysis and transplantation-a prospective cohort study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/54334d5c2ab649ad9b971e206380655f
work_keys_str_mv	AT mikkojjarvisalo dentalhealthassessedusingpanoramicradiographandadverseeventsinchronickidneydiseasestage45patientstransitioningtodialysisandtransplantationaprospectivecohortstudy AT viljamijokihaka dentalhealthassessedusingpanoramicradiographandadverseeventsinchronickidneydiseasestage45patientstransitioningtodialysisandtransplantationaprospectivecohortstudy AT markushakamaki dentalhealthassessedusingpanoramicradiographandadverseeventsinchronickidneydiseasestage45patientstransitioningtodialysisandtransplantationaprospectivecohortstudy AT roosalankinen dentalhealthassessedusingpanoramicradiographandadverseeventsinchronickidneydiseasestage45patientstransitioningtodialysisandtransplantationaprospectivecohortstudy AT heidihelin dentalhealthassessedusingpanoramicradiographandadverseeventsinchronickidneydiseasestage45patientstransitioningtodialysisandtransplantationaprospectivecohortstudy AT niinaskoivuviita dentalhealthassessedusingpanoramicradiographandadverseeventsinchronickidneydiseasestage45patientstransitioningtodialysisandtransplantationaprospectivecohortstudy AT tapiohellman dentalhealthassessedusingpanoramicradiographandadverseeventsinchronickidneydiseasestage45patientstransitioningtodialysisandtransplantationaprospectivecohortstudy AT kajmetsarinne dentalhealthassessedusingpanoramicradiographandadverseeventsinchronickidneydiseasestage45patientstransitioningtodialysisandtransplantationaprospectivecohortstudy
_version_	1718374703815458816

Dental health assessed using panoramic radiograph and adverse events in chronic kidney disease stage 4-5 patients transitioning to dialysis and transplantation-A prospective cohort study.

Ejemplares similares