Myocardial Involvement Detected Using Cardiac Magnetic Resonance Imaging in Patients with Systemic Sclerosis: A Prospective Observational Study

Introduction and objectives: Cardiac involvement in systemic sclerosis (SSc) patients affects mortality. Cardiac magnetic resonance (CMR) is capable of detecting structural changes, including diffuse myocardial fibrosis that may develop over time. Our aim was to evaluate myocardial structure and fun...

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Autores principales:	Milan Hromadka, Jan Baxa, Jitka Seidlerova, Roman Miklik, Dan Rajdl, Vendula Sudova, David Suchy, Richard Rokyta
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	systemic sclerosis cardiac magnetic resonance T1 mapping galectin-3 GDF-15 Medicine R
Acceso en línea:	https://doaj.org/article/5433668a08584064a480784ab230c61f
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spelling	oai:doaj.org-article:5433668a08584064a480784ab230c61f2021-11-25T18:02:09ZMyocardial Involvement Detected Using Cardiac Magnetic Resonance Imaging in Patients with Systemic Sclerosis: A Prospective Observational Study10.3390/jcm102253642077-0383https://doaj.org/article/5433668a08584064a480784ab230c61f2021-11-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/22/5364https://doaj.org/toc/2077-0383Introduction and objectives: Cardiac involvement in systemic sclerosis (SSc) patients affects mortality. Cardiac magnetic resonance (CMR) is capable of detecting structural changes, including diffuse myocardial fibrosis that may develop over time. Our aim was to evaluate myocardial structure and function changes using CMR in patients with SSc without known cardiac disease during a 5-year follow-up and find possible correlations with selected biomarkers. Methods: A total of 25 patients underwent baseline and follow-up CMR examinations according to a pre-specified protocol. Standard biochemistry, five biomarkers (hsTnI, NT-proBNP, galectin-3, sST2, and GDF-15), and disease-specific functional parameters enabling the classification of disease severity were also measured. Results: After five years, no patient suffered from manifest heart disease. Mean extracellular volume (ECV) and T1 mapping values did not change significantly (<i>p</i> ≥ 0.073). However, individual increases in native T1 time and ECV correlated with increased galectin-3 serum levels (r = 0.56; <i>p</i> = 0.0050, and r = 0.71; <i>p</i> = 0.0001, respectively). The progression of skin involvement assessed using the Rodnan skin score and a decrease in the diffusing capacity of the lungs were associated with increased GDF-15 values (r = 0.63; <i>p</i> = 0.0009, and r = −0.51; <i>p</i> = 0.011, respectively). Conclusions: During the 5-year follow-up, there was no new onset of heart disease observed in patients with SSc. However, in some patients, CMR detected progression of sub-clinical myocardial fibrosis that significantly correlated with elevated galectin-3 levels. GDF-15 values were found to be associated with disease severity progression.Milan HromadkaJan BaxaJitka SeidlerovaRoman MiklikDan RajdlVendula SudovaDavid SuchyRichard RokytaMDPI AGarticlesystemic sclerosiscardiac magnetic resonanceT1 mappinggalectin-3GDF-15MedicineRENJournal of Clinical Medicine, Vol 10, Iss 5364, p 5364 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	systemic sclerosis cardiac magnetic resonance T1 mapping galectin-3 GDF-15 Medicine R
spellingShingle	systemic sclerosis cardiac magnetic resonance T1 mapping galectin-3 GDF-15 Medicine R Milan Hromadka Jan Baxa Jitka Seidlerova Roman Miklik Dan Rajdl Vendula Sudova David Suchy Richard Rokyta Myocardial Involvement Detected Using Cardiac Magnetic Resonance Imaging in Patients with Systemic Sclerosis: A Prospective Observational Study
description	Introduction and objectives: Cardiac involvement in systemic sclerosis (SSc) patients affects mortality. Cardiac magnetic resonance (CMR) is capable of detecting structural changes, including diffuse myocardial fibrosis that may develop over time. Our aim was to evaluate myocardial structure and function changes using CMR in patients with SSc without known cardiac disease during a 5-year follow-up and find possible correlations with selected biomarkers. Methods: A total of 25 patients underwent baseline and follow-up CMR examinations according to a pre-specified protocol. Standard biochemistry, five biomarkers (hsTnI, NT-proBNP, galectin-3, sST2, and GDF-15), and disease-specific functional parameters enabling the classification of disease severity were also measured. Results: After five years, no patient suffered from manifest heart disease. Mean extracellular volume (ECV) and T1 mapping values did not change significantly (<i>p</i> ≥ 0.073). However, individual increases in native T1 time and ECV correlated with increased galectin-3 serum levels (r = 0.56; <i>p</i> = 0.0050, and r = 0.71; <i>p</i> = 0.0001, respectively). The progression of skin involvement assessed using the Rodnan skin score and a decrease in the diffusing capacity of the lungs were associated with increased GDF-15 values (r = 0.63; <i>p</i> = 0.0009, and r = −0.51; <i>p</i> = 0.011, respectively). Conclusions: During the 5-year follow-up, there was no new onset of heart disease observed in patients with SSc. However, in some patients, CMR detected progression of sub-clinical myocardial fibrosis that significantly correlated with elevated galectin-3 levels. GDF-15 values were found to be associated with disease severity progression.
format	article
author	Milan Hromadka Jan Baxa Jitka Seidlerova Roman Miklik Dan Rajdl Vendula Sudova David Suchy Richard Rokyta
author_facet	Milan Hromadka Jan Baxa Jitka Seidlerova Roman Miklik Dan Rajdl Vendula Sudova David Suchy Richard Rokyta
author_sort	Milan Hromadka
title	Myocardial Involvement Detected Using Cardiac Magnetic Resonance Imaging in Patients with Systemic Sclerosis: A Prospective Observational Study
title_short	Myocardial Involvement Detected Using Cardiac Magnetic Resonance Imaging in Patients with Systemic Sclerosis: A Prospective Observational Study
title_full	Myocardial Involvement Detected Using Cardiac Magnetic Resonance Imaging in Patients with Systemic Sclerosis: A Prospective Observational Study
title_fullStr	Myocardial Involvement Detected Using Cardiac Magnetic Resonance Imaging in Patients with Systemic Sclerosis: A Prospective Observational Study
title_full_unstemmed	Myocardial Involvement Detected Using Cardiac Magnetic Resonance Imaging in Patients with Systemic Sclerosis: A Prospective Observational Study
title_sort	myocardial involvement detected using cardiac magnetic resonance imaging in patients with systemic sclerosis: a prospective observational study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5433668a08584064a480784ab230c61f
work_keys_str_mv	AT milanhromadka myocardialinvolvementdetectedusingcardiacmagneticresonanceimaginginpatientswithsystemicsclerosisaprospectiveobservationalstudy AT janbaxa myocardialinvolvementdetectedusingcardiacmagneticresonanceimaginginpatientswithsystemicsclerosisaprospectiveobservationalstudy AT jitkaseidlerova myocardialinvolvementdetectedusingcardiacmagneticresonanceimaginginpatientswithsystemicsclerosisaprospectiveobservationalstudy AT romanmiklik myocardialinvolvementdetectedusingcardiacmagneticresonanceimaginginpatientswithsystemicsclerosisaprospectiveobservationalstudy AT danrajdl myocardialinvolvementdetectedusingcardiacmagneticresonanceimaginginpatientswithsystemicsclerosisaprospectiveobservationalstudy AT vendulasudova myocardialinvolvementdetectedusingcardiacmagneticresonanceimaginginpatientswithsystemicsclerosisaprospectiveobservationalstudy AT davidsuchy myocardialinvolvementdetectedusingcardiacmagneticresonanceimaginginpatientswithsystemicsclerosisaprospectiveobservationalstudy AT richardrokyta myocardialinvolvementdetectedusingcardiacmagneticresonanceimaginginpatientswithsystemicsclerosisaprospectiveobservationalstudy
_version_	1718411679738363904

Myocardial Involvement Detected Using Cardiac Magnetic Resonance Imaging in Patients with Systemic Sclerosis: A Prospective Observational Study

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