Impact of birth weight and early infant weight gain on insulin resistance and associated cardiovascular risk factors in adolescence.

<h4>Background</h4>Low birth weight followed by accelerated weight gain during early childhood has been associated with adverse metabolic and cardiovascular outcomes later in life. The aim of this study was to examine the impact of early infant weight gain on glucose metabolism and cardi...

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Autores principales:	Signe Fabricius-Bjerre, Rikke Beck Jensen, Kristine Færch, Torben Larsen, Christian Mølgaard, Kim Fleischer Michaelsen, Allan Vaag, Gorm Greisen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/543d85d0135a440b972121f54db31252
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spelling	oai:doaj.org-article:543d85d0135a440b972121f54db312522021-11-18T06:52:42ZImpact of birth weight and early infant weight gain on insulin resistance and associated cardiovascular risk factors in adolescence.1932-620310.1371/journal.pone.0020595https://doaj.org/article/543d85d0135a440b972121f54db312522011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21655104/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Low birth weight followed by accelerated weight gain during early childhood has been associated with adverse metabolic and cardiovascular outcomes later in life. The aim of this study was to examine the impact of early infant weight gain on glucose metabolism and cardiovascular risk factors in adolescence and to study if the effect differed between adolescents born small for gestational age (SGA) vs. appropriate for gestational age (AGA).<h4>Methodology/principal findings</h4>Data from 30 SGA and 57 AGA healthy young Danish adolescents were analysed. They had a mean age of 17.6 years and all were born at term. Data on early infant weight gain from birth to three months as well as from birth to one year were available in the majority of subjects. In adolescence, glucose metabolism was assessed by a simplified intravenous glucose tolerance test and body composition was assessed by dual-energy X-ray absorptiometry. Blood pressures as well as plasma concentrations of triglycerides and cholesterol were measured. Early infant weight gain from birth to three months was positively associated with the fasting insulin concentration, HOMA-IR, basal lipid levels and systolic blood pressure at 17 years. There was a differential effect of postnatal weight gain on HOMA-IR in AGA and SGA participants (P for interaction = 0.03). No significant associations were seen between postnatal weight gain and body composition or parameters of glucose metabolism assessed by the simplified intravenous glucose tolerance test. In subgroup analysis, all associations with early infant weight gain were absent in the AGA group, but the associations with basal insulin and HOMA-IR were still present in the SGA group.<h4>Conclusion</h4>This study suggests that accelerated growth during the first three months of life may confer an increased risk of later metabolic disturbances--particularly of glucose metabolism--in individuals born SGA.Signe Fabricius-BjerreRikke Beck JensenKristine FærchTorben LarsenChristian MølgaardKim Fleischer MichaelsenAllan VaagGorm GreisenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e20595 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Signe Fabricius-Bjerre Rikke Beck Jensen Kristine Færch Torben Larsen Christian Mølgaard Kim Fleischer Michaelsen Allan Vaag Gorm Greisen Impact of birth weight and early infant weight gain on insulin resistance and associated cardiovascular risk factors in adolescence.
description	<h4>Background</h4>Low birth weight followed by accelerated weight gain during early childhood has been associated with adverse metabolic and cardiovascular outcomes later in life. The aim of this study was to examine the impact of early infant weight gain on glucose metabolism and cardiovascular risk factors in adolescence and to study if the effect differed between adolescents born small for gestational age (SGA) vs. appropriate for gestational age (AGA).<h4>Methodology/principal findings</h4>Data from 30 SGA and 57 AGA healthy young Danish adolescents were analysed. They had a mean age of 17.6 years and all were born at term. Data on early infant weight gain from birth to three months as well as from birth to one year were available in the majority of subjects. In adolescence, glucose metabolism was assessed by a simplified intravenous glucose tolerance test and body composition was assessed by dual-energy X-ray absorptiometry. Blood pressures as well as plasma concentrations of triglycerides and cholesterol were measured. Early infant weight gain from birth to three months was positively associated with the fasting insulin concentration, HOMA-IR, basal lipid levels and systolic blood pressure at 17 years. There was a differential effect of postnatal weight gain on HOMA-IR in AGA and SGA participants (P for interaction = 0.03). No significant associations were seen between postnatal weight gain and body composition or parameters of glucose metabolism assessed by the simplified intravenous glucose tolerance test. In subgroup analysis, all associations with early infant weight gain were absent in the AGA group, but the associations with basal insulin and HOMA-IR were still present in the SGA group.<h4>Conclusion</h4>This study suggests that accelerated growth during the first three months of life may confer an increased risk of later metabolic disturbances--particularly of glucose metabolism--in individuals born SGA.
format	article
author	Signe Fabricius-Bjerre Rikke Beck Jensen Kristine Færch Torben Larsen Christian Mølgaard Kim Fleischer Michaelsen Allan Vaag Gorm Greisen
author_facet	Signe Fabricius-Bjerre Rikke Beck Jensen Kristine Færch Torben Larsen Christian Mølgaard Kim Fleischer Michaelsen Allan Vaag Gorm Greisen
author_sort	Signe Fabricius-Bjerre
title	Impact of birth weight and early infant weight gain on insulin resistance and associated cardiovascular risk factors in adolescence.
title_short	Impact of birth weight and early infant weight gain on insulin resistance and associated cardiovascular risk factors in adolescence.
title_full	Impact of birth weight and early infant weight gain on insulin resistance and associated cardiovascular risk factors in adolescence.
title_fullStr	Impact of birth weight and early infant weight gain on insulin resistance and associated cardiovascular risk factors in adolescence.
title_full_unstemmed	Impact of birth weight and early infant weight gain on insulin resistance and associated cardiovascular risk factors in adolescence.
title_sort	impact of birth weight and early infant weight gain on insulin resistance and associated cardiovascular risk factors in adolescence.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/543d85d0135a440b972121f54db31252
work_keys_str_mv	AT signefabriciusbjerre impactofbirthweightandearlyinfantweightgainoninsulinresistanceandassociatedcardiovascularriskfactorsinadolescence AT rikkebeckjensen impactofbirthweightandearlyinfantweightgainoninsulinresistanceandassociatedcardiovascularriskfactorsinadolescence AT kristinefærch impactofbirthweightandearlyinfantweightgainoninsulinresistanceandassociatedcardiovascularriskfactorsinadolescence AT torbenlarsen impactofbirthweightandearlyinfantweightgainoninsulinresistanceandassociatedcardiovascularriskfactorsinadolescence AT christianmølgaard impactofbirthweightandearlyinfantweightgainoninsulinresistanceandassociatedcardiovascularriskfactorsinadolescence AT kimfleischermichaelsen impactofbirthweightandearlyinfantweightgainoninsulinresistanceandassociatedcardiovascularriskfactorsinadolescence AT allanvaag impactofbirthweightandearlyinfantweightgainoninsulinresistanceandassociatedcardiovascularriskfactorsinadolescence AT gormgreisen impactofbirthweightandearlyinfantweightgainoninsulinresistanceandassociatedcardiovascularriskfactorsinadolescence
_version_	1718424229548916736

Impact of birth weight and early infant weight gain on insulin resistance and associated cardiovascular risk factors in adolescence.

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