Current Practices and Gaps in Management of Dyslipidemia in Type 2 Diabetes Mellitus (T2DM) in Accordance with American Diabetes Association (ADA) Guidelines: A Subset Analysis from a Real-World, Cross-Sectional Observational Study (LEADD Study)

Ashok Kumar Das,1 Banshi Saboo,2 Ambika G Unnikrishnan3 1Department of Endocrinology, Pondicherry Institute of Medical Sciences, Pondicherry, India; 2Department of Endocrinology, Dia Care, Ahmedabad, Gujarat, India; 3Department of Endocrinology, Chellaram Diabetes Institute, Pune, Maharashtra, India...

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Autores principales:	Das AK, Saboo B, Unnikrishnan AG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	diabetic dyslipidemia hyperlipidemia in diabetes abnormal lipid profile in diabetes dyslipidemia in diabetes hypercholesteremia in diabetes Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/543e11c86d73494d9b30cde36f0b6567
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spelling	oai:doaj.org-article:543e11c86d73494d9b30cde36f0b65672021-12-02T17:22:58ZCurrent Practices and Gaps in Management of Dyslipidemia in Type 2 Diabetes Mellitus (T2DM) in Accordance with American Diabetes Association (ADA) Guidelines: A Subset Analysis from a Real-World, Cross-Sectional Observational Study (LEADD Study)1178-7007https://doaj.org/article/543e11c86d73494d9b30cde36f0b65672021-06-01T00:00:00Zhttps://www.dovepress.com/current-practices-and-gaps-in-management-of-dyslipidemia-in-type-2-dia-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Ashok Kumar Das,1 Banshi Saboo,2 Ambika G Unnikrishnan3 1Department of Endocrinology, Pondicherry Institute of Medical Sciences, Pondicherry, India; 2Department of Endocrinology, Dia Care, Ahmedabad, Gujarat, India; 3Department of Endocrinology, Chellaram Diabetes Institute, Pune, Maharashtra, IndiaCorrespondence: Ambika G UnnikrishnanDepartment of Endocrinology, Chellaram Diabetes Institute, Pune, 411021, Maharashtra, IndiaTel +91 8605011934Email info@mediception.comBackground: Diabetic dyslipidemia is a risk factor for coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). American Diabetes Association (ADA) provides internationally accepted guidelines to manage dyslipidemia in T2DM.Objective: To assess if ADA guidelines are followed for managing dyslipidemia in patients with T2DM in India.Methods: This was a subset analysis of a prospective, cross sectional, observational study (LEADD Study) conducted at 199 sites across India to evaluate dyslipidemia management practices in T2DM patients (N=4002), in a real-world setting. The data was stratified based on age and atherosclerotic cardiovascular disease (ASCVD) and ASCVD risk factors to record the percentages of T2DM patients achieving LDL-C target and treated optimally with the Guideline directed intensity of statin. Analysis was conducted using descriptive statistics.Results: As per ADA 2018 targets: LDL-C levels (< 100mg/dL) were seen in 30.6% of participants. High intensity statins were prescribed to 13.4% of the participants with LDL levels ≥ 100 mg/dL. ASCVD risk assessment details were available for 89.2% of participants. Data was not available for smoking and albuminuria. In participants < 40 years of age, 80% and 64.2% with ASCVD and ASCVD risk factors, respectively, did not achieve target LDL-C levels. In this age group, 15.6% and 83.3% of participants with ASCVD risk factors and ASCVD group, respectively, were not receiving statins in the recommended dose. In participants ≥ 40 years of age, 88.0% and 91.5% with ASCVD and ASCVD risk factors, respectively, did not have LDL-C levels as per ADA 2018 targets. In this age group, 87.2% and 77.9% of participants with ASCVD risk factors and ASCVD, respectively, were not receiving statins in the recommended dose.Conclusion: The sub-analysis of LEADD study shows sub-optimal adherence to ADA 2018 guidelines for management of diabetic dyslipidemia.Keywords: diabetic dyslipidemia, hyperlipidemia in diabetes, abnormal lipid profile in diabetes, dyslipidemia in diabetes, hypercholesteremia in diabetesDas AKSaboo BUnnikrishnan AGDove Medical Pressarticlediabetic dyslipidemiahyperlipidemia in diabetesabnormal lipid profile in diabetesdyslipidemia in diabeteshypercholesteremia in diabetesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 2693-2700 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic dyslipidemia hyperlipidemia in diabetes abnormal lipid profile in diabetes dyslipidemia in diabetes hypercholesteremia in diabetes Specialties of internal medicine RC581-951
spellingShingle	diabetic dyslipidemia hyperlipidemia in diabetes abnormal lipid profile in diabetes dyslipidemia in diabetes hypercholesteremia in diabetes Specialties of internal medicine RC581-951 Das AK Saboo B Unnikrishnan AG Current Practices and Gaps in Management of Dyslipidemia in Type 2 Diabetes Mellitus (T2DM) in Accordance with American Diabetes Association (ADA) Guidelines: A Subset Analysis from a Real-World, Cross-Sectional Observational Study (LEADD Study)
description	Ashok Kumar Das,1 Banshi Saboo,2 Ambika G Unnikrishnan3 1Department of Endocrinology, Pondicherry Institute of Medical Sciences, Pondicherry, India; 2Department of Endocrinology, Dia Care, Ahmedabad, Gujarat, India; 3Department of Endocrinology, Chellaram Diabetes Institute, Pune, Maharashtra, IndiaCorrespondence: Ambika G UnnikrishnanDepartment of Endocrinology, Chellaram Diabetes Institute, Pune, 411021, Maharashtra, IndiaTel +91 8605011934Email info@mediception.comBackground: Diabetic dyslipidemia is a risk factor for coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). American Diabetes Association (ADA) provides internationally accepted guidelines to manage dyslipidemia in T2DM.Objective: To assess if ADA guidelines are followed for managing dyslipidemia in patients with T2DM in India.Methods: This was a subset analysis of a prospective, cross sectional, observational study (LEADD Study) conducted at 199 sites across India to evaluate dyslipidemia management practices in T2DM patients (N=4002), in a real-world setting. The data was stratified based on age and atherosclerotic cardiovascular disease (ASCVD) and ASCVD risk factors to record the percentages of T2DM patients achieving LDL-C target and treated optimally with the Guideline directed intensity of statin. Analysis was conducted using descriptive statistics.Results: As per ADA 2018 targets: LDL-C levels (< 100mg/dL) were seen in 30.6% of participants. High intensity statins were prescribed to 13.4% of the participants with LDL levels ≥ 100 mg/dL. ASCVD risk assessment details were available for 89.2% of participants. Data was not available for smoking and albuminuria. In participants < 40 years of age, 80% and 64.2% with ASCVD and ASCVD risk factors, respectively, did not achieve target LDL-C levels. In this age group, 15.6% and 83.3% of participants with ASCVD risk factors and ASCVD group, respectively, were not receiving statins in the recommended dose. In participants ≥ 40 years of age, 88.0% and 91.5% with ASCVD and ASCVD risk factors, respectively, did not have LDL-C levels as per ADA 2018 targets. In this age group, 87.2% and 77.9% of participants with ASCVD risk factors and ASCVD, respectively, were not receiving statins in the recommended dose.Conclusion: The sub-analysis of LEADD study shows sub-optimal adherence to ADA 2018 guidelines for management of diabetic dyslipidemia.Keywords: diabetic dyslipidemia, hyperlipidemia in diabetes, abnormal lipid profile in diabetes, dyslipidemia in diabetes, hypercholesteremia in diabetes
format	article
author	Das AK Saboo B Unnikrishnan AG
author_facet	Das AK Saboo B Unnikrishnan AG
author_sort	Das AK
title	Current Practices and Gaps in Management of Dyslipidemia in Type 2 Diabetes Mellitus (T2DM) in Accordance with American Diabetes Association (ADA) Guidelines: A Subset Analysis from a Real-World, Cross-Sectional Observational Study (LEADD Study)
title_short	Current Practices and Gaps in Management of Dyslipidemia in Type 2 Diabetes Mellitus (T2DM) in Accordance with American Diabetes Association (ADA) Guidelines: A Subset Analysis from a Real-World, Cross-Sectional Observational Study (LEADD Study)
title_full	Current Practices and Gaps in Management of Dyslipidemia in Type 2 Diabetes Mellitus (T2DM) in Accordance with American Diabetes Association (ADA) Guidelines: A Subset Analysis from a Real-World, Cross-Sectional Observational Study (LEADD Study)
title_fullStr	Current Practices and Gaps in Management of Dyslipidemia in Type 2 Diabetes Mellitus (T2DM) in Accordance with American Diabetes Association (ADA) Guidelines: A Subset Analysis from a Real-World, Cross-Sectional Observational Study (LEADD Study)
title_full_unstemmed	Current Practices and Gaps in Management of Dyslipidemia in Type 2 Diabetes Mellitus (T2DM) in Accordance with American Diabetes Association (ADA) Guidelines: A Subset Analysis from a Real-World, Cross-Sectional Observational Study (LEADD Study)
title_sort	current practices and gaps in management of dyslipidemia in type 2 diabetes mellitus (t2dm) in accordance with american diabetes association (ada) guidelines: a subset analysis from a real-world, cross-sectional observational study (leadd study)
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/543e11c86d73494d9b30cde36f0b6567
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Current Practices and Gaps in Management of Dyslipidemia in Type 2 Diabetes Mellitus (T2DM) in Accordance with American Diabetes Association (ADA) Guidelines: A Subset Analysis from a Real-World, Cross-Sectional Observational Study (LEADD Study)

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