Mapping the electrostatic potential of the nucleosome acidic patch

Abstract The nucleosome surface contains an area with negative electrostatic potential known as the acidic patch, which functions as a binding platform for various proteins to regulate chromatin biology. The dense clustering of acidic residues may impact their effective pKa and thus the electronegat...

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Autores principales: Heyi Zhang, Jelmer Eerland, Velten Horn, Raymond Schellevis, Hugo van Ingen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/544c1de6121f412da6043bec52db0a82
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