Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage

Ada Gjyrezi et al. show that ddPCR can be used to accurately measure androgen receptor variant (AR-V) expression levels in single circulating tumor cells (CTCs) from prostate cancer patients. They show that current methods for isolating CTCs tend to underestimate the prevalence of AR-V and that a sp...

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Autores principales:	Ada Gjyrezi, Giuseppe Galletti, Jiaren Zhang, Daniel Worroll, Michael Sigouros, Seaho Kim, Victoria Cooley, Karla V. Ballman, Allyson J. Ocean, Manish A. Shah, Joseph M. Scandura, Andrea Sboner, David M. Nanus, Himisha Beltran, Scott Tagawa, Paraskevi Giannakakou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/54507da59cc5412fa5d4da9b3a601956
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:54507da59cc5412fa5d4da9b3a6019562021-12-02T18:02:53ZAndrogen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage10.1038/s42003-021-02321-92399-3642https://doaj.org/article/54507da59cc5412fa5d4da9b3a6019562021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02321-9https://doaj.org/toc/2399-3642Ada Gjyrezi et al. show that ddPCR can be used to accurately measure androgen receptor variant (AR-V) expression levels in single circulating tumor cells (CTCs) from prostate cancer patients. They show that current methods for isolating CTCs tend to underestimate the prevalence of AR-V and that a specific variant, AR-v567es, could be potentially used as a biomarker for an aggressive subtype of prostate cancer.Ada GjyreziGiuseppe GallettiJiaren ZhangDaniel WorrollMichael SigourosSeaho KimVictoria CooleyKarla V. BallmanAllyson J. OceanManish A. ShahJoseph M. ScanduraAndrea SbonerDavid M. NanusHimisha BeltranScott TagawaParaskevi GiannakakouNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ada Gjyrezi Giuseppe Galletti Jiaren Zhang Daniel Worroll Michael Sigouros Seaho Kim Victoria Cooley Karla V. Ballman Allyson J. Ocean Manish A. Shah Joseph M. Scandura Andrea Sboner David M. Nanus Himisha Beltran Scott Tagawa Paraskevi Giannakakou Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage
description	Ada Gjyrezi et al. show that ddPCR can be used to accurately measure androgen receptor variant (AR-V) expression levels in single circulating tumor cells (CTCs) from prostate cancer patients. They show that current methods for isolating CTCs tend to underestimate the prevalence of AR-V and that a specific variant, AR-v567es, could be potentially used as a biomarker for an aggressive subtype of prostate cancer.
format	article
author	Ada Gjyrezi Giuseppe Galletti Jiaren Zhang Daniel Worroll Michael Sigouros Seaho Kim Victoria Cooley Karla V. Ballman Allyson J. Ocean Manish A. Shah Joseph M. Scandura Andrea Sboner David M. Nanus Himisha Beltran Scott Tagawa Paraskevi Giannakakou
author_facet	Ada Gjyrezi Giuseppe Galletti Jiaren Zhang Daniel Worroll Michael Sigouros Seaho Kim Victoria Cooley Karla V. Ballman Allyson J. Ocean Manish A. Shah Joseph M. Scandura Andrea Sboner David M. Nanus Himisha Beltran Scott Tagawa Paraskevi Giannakakou
author_sort	Ada Gjyrezi
title	Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage
title_short	Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage
title_full	Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage
title_fullStr	Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage
title_full_unstemmed	Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage
title_sort	androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/54507da59cc5412fa5d4da9b3a601956
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Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage

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