Topiramate and the vision: a systematic review

Mohammad-Ali Abtahi1&ndash;3, Seyed-Hossein Abtahi1,3,4, Farhad Fazel2,3, Peyman Roomizadeh1,4, Masoud Etemadifar5, Keivan Jenab2,3, Mojtaba Akbari11Medical School, Isfahan University of Medical Sciences, 2Ophthalmology Ward, Feiz Hospital, Isfahan University of Medical Sciences, 3Isfahan Ey...

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Autores principales:	Abtahi MA, Abtahi SH, Fazel F, Roomizadeh P, Etemadifar M, Jenab K, Akbari M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/545c46d14aaf4125a68fb8ae69151a52
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spelling	oai:doaj.org-article:545c46d14aaf4125a68fb8ae69151a522021-12-02T03:44:17ZTopiramate and the vision: a systematic review1177-54671177-5483https://doaj.org/article/545c46d14aaf4125a68fb8ae69151a522012-01-01T00:00:00Zhttp://www.dovepress.com/topiramate-and-the-vision-a-systematic-review-a9050https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Mohammad-Ali Abtahi1&ndash;3, Seyed-Hossein Abtahi1,3,4, Farhad Fazel2,3, Peyman Roomizadeh1,4, Masoud Etemadifar5, Keivan Jenab2,3, Mojtaba Akbari11Medical School, Isfahan University of Medical Sciences, 2Ophthalmology Ward, Feiz Hospital, Isfahan University of Medical Sciences, 3Isfahan Eye Research Center (IERC), Feiz Hospital, Isfahan University of Medical Sciences, 4Isfahan Medical Students Research Center (IMSRC), Isfahan University of Medical Sciences, 5Department of Neurology, Medical School, Isfahan University of Medical Sciences, Isfahan, IranBackground and purpose: Topiramate (TPM) is a sulfa-derivative monosaccharide that is used mainly for treating epilepsy and preventing migraine. Within the gamut of side effects attributable to this drug, ophthalmologic manifestations are of crucial importance. In this study, for the first time, the aim was to provide a systematic literature review regarding this issue.Methods: For the time period 1996&ndash;2011, a PubMed search was made for the studies concerning the adverse/beneficial effects of TPM on vision. Overall, 404 citations out of a total of 2756 TPM-related studies were examined for relevance.Results: A total of 74 relevant studies were reviewed, 65 of which comprise small observational studies describing the ophthalmic side effects of TPM in 84 patients. Of these patients, 66 were affected by ciliochoroidal effusion syndrome as the cardinal ocular side effect of TPM (17 cases of myopic shift and 49 cases of angle closure glaucoma). A comprehensive statistical analysis is provided on these 66 subjects. Other rare side effects of TPM on the vision were also reviewed, including massive choroidal effusion, ocular inflammatory reactions, visual field defects, probable effects on retina, cornea, and sclera, and neuroophthalmologic complications. In addition, a framework is provided to classify these results.Discussion: Due to the expanding spectrum of indications for the administration of TPM, neurologists and psychiatrists should be aware of its diverse ocular side effects. In conclusion, ocular complications following this drug should be taken seriously and be subjected to ophthalmic counseling.Keywords: topiramate, eye, vision, ophthalmology, side effect, reviewAbtahi MAAbtahi SHFazel FRoomizadeh PEtemadifar MJenab KAkbari MDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 117-131 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Abtahi MA Abtahi SH Fazel F Roomizadeh P Etemadifar M Jenab K Akbari M Topiramate and the vision: a systematic review
description	Mohammad-Ali Abtahi1&ndash;3, Seyed-Hossein Abtahi1,3,4, Farhad Fazel2,3, Peyman Roomizadeh1,4, Masoud Etemadifar5, Keivan Jenab2,3, Mojtaba Akbari11Medical School, Isfahan University of Medical Sciences, 2Ophthalmology Ward, Feiz Hospital, Isfahan University of Medical Sciences, 3Isfahan Eye Research Center (IERC), Feiz Hospital, Isfahan University of Medical Sciences, 4Isfahan Medical Students Research Center (IMSRC), Isfahan University of Medical Sciences, 5Department of Neurology, Medical School, Isfahan University of Medical Sciences, Isfahan, IranBackground and purpose: Topiramate (TPM) is a sulfa-derivative monosaccharide that is used mainly for treating epilepsy and preventing migraine. Within the gamut of side effects attributable to this drug, ophthalmologic manifestations are of crucial importance. In this study, for the first time, the aim was to provide a systematic literature review regarding this issue.Methods: For the time period 1996&ndash;2011, a PubMed search was made for the studies concerning the adverse/beneficial effects of TPM on vision. Overall, 404 citations out of a total of 2756 TPM-related studies were examined for relevance.Results: A total of 74 relevant studies were reviewed, 65 of which comprise small observational studies describing the ophthalmic side effects of TPM in 84 patients. Of these patients, 66 were affected by ciliochoroidal effusion syndrome as the cardinal ocular side effect of TPM (17 cases of myopic shift and 49 cases of angle closure glaucoma). A comprehensive statistical analysis is provided on these 66 subjects. Other rare side effects of TPM on the vision were also reviewed, including massive choroidal effusion, ocular inflammatory reactions, visual field defects, probable effects on retina, cornea, and sclera, and neuroophthalmologic complications. In addition, a framework is provided to classify these results.Discussion: Due to the expanding spectrum of indications for the administration of TPM, neurologists and psychiatrists should be aware of its diverse ocular side effects. In conclusion, ocular complications following this drug should be taken seriously and be subjected to ophthalmic counseling.Keywords: topiramate, eye, vision, ophthalmology, side effect, review
format	article
author	Abtahi MA Abtahi SH Fazel F Roomizadeh P Etemadifar M Jenab K Akbari M
author_facet	Abtahi MA Abtahi SH Fazel F Roomizadeh P Etemadifar M Jenab K Akbari M
author_sort	Abtahi MA
title	Topiramate and the vision: a systematic review
title_short	Topiramate and the vision: a systematic review
title_full	Topiramate and the vision: a systematic review
title_fullStr	Topiramate and the vision: a systematic review
title_full_unstemmed	Topiramate and the vision: a systematic review
title_sort	topiramate and the vision: a systematic review
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/545c46d14aaf4125a68fb8ae69151a52
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Topiramate and the vision: a systematic review

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