VOLUMETRIC PROPERTIES OF THE PHARMACEUTICAL MODEL COSOLVENT SYSTEM 1,4-DIOXANE + WATER AT SEVERAL TEMPERATURES

Although the cosolvent system 1,4-dioxane+ water is poisonous, it is widely used in the pharmaceutical sciences as a versatile model for studying drug solubility and some other relevant physicochemical properties in the design of homogeneous dosage forms. For this reason, the excess molar volumes a...

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Autores principales:	Miller A. RUIDIAZ M., Fleming MARTÍNEZ R.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	1 4-dioxane water binary liquid mixtures excess volumes partial volumes. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/5462a5461c2e4866baaddcd25e0e396a
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spelling	oai:doaj.org-article:5462a5461c2e4866baaddcd25e0e396a2021-11-19T04:14:54ZVOLUMETRIC PROPERTIES OF THE PHARMACEUTICAL MODEL COSOLVENT SYSTEM 1,4-DIOXANE + WATER AT SEVERAL TEMPERATURES0121-40042145-2660https://doaj.org/article/5462a5461c2e4866baaddcd25e0e396a2009-11-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/2803https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660 Although the cosolvent system 1,4-dioxane+ water is poisonous, it is widely used in the pharmaceutical sciences as a versatile model for studying drug solubility and some other relevant physicochemical properties in the design of homogeneous dosage forms. For this reason, the excess molar volumes and partial molar volumes of components are investigated from density measurements of the entire range of mass fractions for the 1,4-dioxane + water system at 293.15 K; 298.15 K; 303.15 K; 308.15 K and 313.15 K. The results of excess molar volumes are fitted by Redlich-Kister equation using third degree polynomials and compared with those of literature for other systems. The system exhibits large negative excess volumes (up to – 0.71 cm3 mol–1) probably due to increased interactions like hydrogen bonding between unlike molecules or very large differences in the molar volumes of pure components. The effect of temperature on the different volumetric properties studied is also analyzed. Besides, the volume thermal expansion coefficients are also calculated founding values varying from 2.50 x 10–4 K–1 for pure water up to 1.06 x 10–3 K–1 for pure 1,4-dioxane at 298.15 K. Miller A. RUIDIAZ M.Fleming MARTÍNEZ R.Universidad de Antioquiaarticle14-dioxanewaterbinary liquid mixturesexcess volumespartial volumes.Food processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 16, Iss 3 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	1 4-dioxane water binary liquid mixtures excess volumes partial volumes. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	1 4-dioxane water binary liquid mixtures excess volumes partial volumes. Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Miller A. RUIDIAZ M. Fleming MARTÍNEZ R. VOLUMETRIC PROPERTIES OF THE PHARMACEUTICAL MODEL COSOLVENT SYSTEM 1,4-DIOXANE + WATER AT SEVERAL TEMPERATURES
description	Although the cosolvent system 1,4-dioxane+ water is poisonous, it is widely used in the pharmaceutical sciences as a versatile model for studying drug solubility and some other relevant physicochemical properties in the design of homogeneous dosage forms. For this reason, the excess molar volumes and partial molar volumes of components are investigated from density measurements of the entire range of mass fractions for the 1,4-dioxane + water system at 293.15 K; 298.15 K; 303.15 K; 308.15 K and 313.15 K. The results of excess molar volumes are fitted by Redlich-Kister equation using third degree polynomials and compared with those of literature for other systems. The system exhibits large negative excess volumes (up to – 0.71 cm3 mol–1) probably due to increased interactions like hydrogen bonding between unlike molecules or very large differences in the molar volumes of pure components. The effect of temperature on the different volumetric properties studied is also analyzed. Besides, the volume thermal expansion coefficients are also calculated founding values varying from 2.50 x 10–4 K–1 for pure water up to 1.06 x 10–3 K–1 for pure 1,4-dioxane at 298.15 K.
format	article
author	Miller A. RUIDIAZ M. Fleming MARTÍNEZ R.
author_facet	Miller A. RUIDIAZ M. Fleming MARTÍNEZ R.
author_sort	Miller A. RUIDIAZ M.
title	VOLUMETRIC PROPERTIES OF THE PHARMACEUTICAL MODEL COSOLVENT SYSTEM 1,4-DIOXANE + WATER AT SEVERAL TEMPERATURES
title_short	VOLUMETRIC PROPERTIES OF THE PHARMACEUTICAL MODEL COSOLVENT SYSTEM 1,4-DIOXANE + WATER AT SEVERAL TEMPERATURES
title_full	VOLUMETRIC PROPERTIES OF THE PHARMACEUTICAL MODEL COSOLVENT SYSTEM 1,4-DIOXANE + WATER AT SEVERAL TEMPERATURES
title_fullStr	VOLUMETRIC PROPERTIES OF THE PHARMACEUTICAL MODEL COSOLVENT SYSTEM 1,4-DIOXANE + WATER AT SEVERAL TEMPERATURES
title_full_unstemmed	VOLUMETRIC PROPERTIES OF THE PHARMACEUTICAL MODEL COSOLVENT SYSTEM 1,4-DIOXANE + WATER AT SEVERAL TEMPERATURES
title_sort	volumetric properties of the pharmaceutical model cosolvent system 1,4-dioxane + water at several temperatures
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/5462a5461c2e4866baaddcd25e0e396a
work_keys_str_mv	AT milleraruidiazm volumetricpropertiesofthepharmaceuticalmodelcosolventsystem14dioxanewateratseveraltemperatures AT flemingmartinezr volumetricpropertiesofthepharmaceuticalmodelcosolventsystem14dioxanewateratseveraltemperatures
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VOLUMETRIC PROPERTIES OF THE PHARMACEUTICAL MODEL COSOLVENT SYSTEM 1,4-DIOXANE + WATER AT SEVERAL TEMPERATURES

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