Gene interfered-ferroptosis therapy for cancers

Improved therapeutic strategies are needed as drug resistance limits the therapeutic efficacy of several clinically approved cancer therapeutics. Here, the authors report a ferroptosis-based therapy using a combination of iron nanoparticles with gene interference to knockdown iron metabolic genes, F...

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Autores principales:	Jinliang Gao, Tao Luo, Jinke Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5464252191f34f768b296b56545dfe08
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spelling	oai:doaj.org-article:5464252191f34f768b296b56545dfe082021-12-02T17:42:11ZGene interfered-ferroptosis therapy for cancers10.1038/s41467-021-25632-12041-1723https://doaj.org/article/5464252191f34f768b296b56545dfe082021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25632-1https://doaj.org/toc/2041-1723Improved therapeutic strategies are needed as drug resistance limits the therapeutic efficacy of several clinically approved cancer therapeutics. Here, the authors report a ferroptosis-based therapy using a combination of iron nanoparticles with gene interference to knockdown iron metabolic genes, FPN and LCN2.Jinliang GaoTao LuoJinke WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinliang Gao Tao Luo Jinke Wang Gene interfered-ferroptosis therapy for cancers
description	Improved therapeutic strategies are needed as drug resistance limits the therapeutic efficacy of several clinically approved cancer therapeutics. Here, the authors report a ferroptosis-based therapy using a combination of iron nanoparticles with gene interference to knockdown iron metabolic genes, FPN and LCN2.
format	article
author	Jinliang Gao Tao Luo Jinke Wang
author_facet	Jinliang Gao Tao Luo Jinke Wang
author_sort	Jinliang Gao
title	Gene interfered-ferroptosis therapy for cancers
title_short	Gene interfered-ferroptosis therapy for cancers
title_full	Gene interfered-ferroptosis therapy for cancers
title_fullStr	Gene interfered-ferroptosis therapy for cancers
title_full_unstemmed	Gene interfered-ferroptosis therapy for cancers
title_sort	gene interfered-ferroptosis therapy for cancers
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5464252191f34f768b296b56545dfe08
work_keys_str_mv	AT jinlianggao geneinterferedferroptosistherapyforcancers AT taoluo geneinterferedferroptosistherapyforcancers AT jinkewang geneinterferedferroptosistherapyforcancers
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Gene interfered-ferroptosis therapy for cancers

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