Effects of Short-Term Dietary Fiber Intervention on Gut Microbiota in Young Healthy People

Tian Tian,1,&ast; Xiaobo Zhang,1,&ast; Tao Luo,1 Duolao Wang,2 Yuping Sun,3 Jianghong Dai1 1Department of Epidemiology and Biostatistics, School of Public Health, Xinjiang Medical University, Urumqi, 830001, People’s Republic of China; 2Department of Clinical Sciences, Liverpool School of Tr...

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Autores principales:	Tian T, Zhang X, Luo T, Wang D, Sun Y, Dai J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	dietary fiber gut microbiota short-term intervention Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/54645c68bf864ebba395facb2b461404
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spelling	oai:doaj.org-article:54645c68bf864ebba395facb2b4614042021-12-02T14:51:49ZEffects of Short-Term Dietary Fiber Intervention on Gut Microbiota in Young Healthy People1178-7007https://doaj.org/article/54645c68bf864ebba395facb2b4614042021-08-01T00:00:00Zhttps://www.dovepress.com/effects-of-short-term-dietary-fiber-intervention-on-gut-microbiota-in--peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Tian Tian,1,&ast; Xiaobo Zhang,1,&ast; Tao Luo,1 Duolao Wang,2 Yuping Sun,3 Jianghong Dai1 1Department of Epidemiology and Biostatistics, School of Public Health, Xinjiang Medical University, Urumqi, 830001, People’s Republic of China; 2Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, L35QAUK, UK; 3School of Basic Medicine, Xinjiang Medical University, Urumqi, 830001, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jianghong Dai Tel +86-991-4365530Email epidjh@163.comAbstract: Gut microbiota are critical to many aspects of human health including immune and metabolic health. Long-term diet influences the community structure and activity of the trillions of microorganisms residing in the human gut, but it remains unclear how the human gut microbiome responds to short-term intervention with dietary fiber. This study explored the effects of mixed dietary fibers on gut microbiota in young, healthy people. Twelve healthy, young adults participated in a randomized, crossover trial comparing the effects of polyglucan, inulin and resistant malt dextrin on gut microbiota composition and bacterial abundances. During the study, the subjects followed their normal diets without any constraints. Microbial community profiles were determined by absolute quantification 16S rRNA gene amplicon sequencing. Mixed model analysis did not reveal an effect of dietary intervention on microbial community structure. At the genus level, dietary fiber intervention for 4 days significantly promoted the growth of Alloprevotella, Parabacteroides and Parasutterella and inhibited the growth of Adlercreutzia, Anaerovorax, Enterococcus, Intestinibacter and Ruminococcus 2 compared with the baseline. Addition of whey albumen powder for 4 days promoted the growth of Corynebacterium, Collinsella, Olsenella and Lactococcus but interfered with the growth of Megasphaera. Our results should be corroborated by randomized clinical trials with large sample size.Keywords: dietary fiber, gut microbiota, short-term interventionTian TZhang XLuo TWang DSun YDai JDove Medical Pressarticledietary fibergut microbiotashort-term interventionSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 3507-3516 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dietary fiber gut microbiota short-term intervention Specialties of internal medicine RC581-951
spellingShingle	dietary fiber gut microbiota short-term intervention Specialties of internal medicine RC581-951 Tian T Zhang X Luo T Wang D Sun Y Dai J Effects of Short-Term Dietary Fiber Intervention on Gut Microbiota in Young Healthy People
description	Tian Tian,1,&ast; Xiaobo Zhang,1,&ast; Tao Luo,1 Duolao Wang,2 Yuping Sun,3 Jianghong Dai1 1Department of Epidemiology and Biostatistics, School of Public Health, Xinjiang Medical University, Urumqi, 830001, People’s Republic of China; 2Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, L35QAUK, UK; 3School of Basic Medicine, Xinjiang Medical University, Urumqi, 830001, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jianghong Dai Tel +86-991-4365530Email epidjh@163.comAbstract: Gut microbiota are critical to many aspects of human health including immune and metabolic health. Long-term diet influences the community structure and activity of the trillions of microorganisms residing in the human gut, but it remains unclear how the human gut microbiome responds to short-term intervention with dietary fiber. This study explored the effects of mixed dietary fibers on gut microbiota in young, healthy people. Twelve healthy, young adults participated in a randomized, crossover trial comparing the effects of polyglucan, inulin and resistant malt dextrin on gut microbiota composition and bacterial abundances. During the study, the subjects followed their normal diets without any constraints. Microbial community profiles were determined by absolute quantification 16S rRNA gene amplicon sequencing. Mixed model analysis did not reveal an effect of dietary intervention on microbial community structure. At the genus level, dietary fiber intervention for 4 days significantly promoted the growth of Alloprevotella, Parabacteroides and Parasutterella and inhibited the growth of Adlercreutzia, Anaerovorax, Enterococcus, Intestinibacter and Ruminococcus 2 compared with the baseline. Addition of whey albumen powder for 4 days promoted the growth of Corynebacterium, Collinsella, Olsenella and Lactococcus but interfered with the growth of Megasphaera. Our results should be corroborated by randomized clinical trials with large sample size.Keywords: dietary fiber, gut microbiota, short-term intervention
format	article
author	Tian T Zhang X Luo T Wang D Sun Y Dai J
author_facet	Tian T Zhang X Luo T Wang D Sun Y Dai J
author_sort	Tian T
title	Effects of Short-Term Dietary Fiber Intervention on Gut Microbiota in Young Healthy People
title_short	Effects of Short-Term Dietary Fiber Intervention on Gut Microbiota in Young Healthy People
title_full	Effects of Short-Term Dietary Fiber Intervention on Gut Microbiota in Young Healthy People
title_fullStr	Effects of Short-Term Dietary Fiber Intervention on Gut Microbiota in Young Healthy People
title_full_unstemmed	Effects of Short-Term Dietary Fiber Intervention on Gut Microbiota in Young Healthy People
title_sort	effects of short-term dietary fiber intervention on gut microbiota in young healthy people
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/54645c68bf864ebba395facb2b461404
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Effects of Short-Term Dietary Fiber Intervention on Gut Microbiota in Young Healthy People

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