Dextrin and polyurethane graft copolymers as drug carrier: Synthesis, characterization, drug release, biocompatibility and in-vitro toxicity

Chemical modification of dextrin with polyurethane as a graft has been synthesized for controlled drug release for longer time period by maintaining the hydrophobic–hydrophilic balance. Estimation of the degree of grafting is visualized from the integrated peak area in the NMR spectra. Particle natu...

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Autores principales:	Aparna Shukla, Swapan Maity, Biswajit Ray, Pralay Maiti
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Dextrin Hydrophilic–hydrophobic balance Thermal stability Morphology Drug delivery Cellular studies Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/546aba3faf4541ae8b7f35296aa74145
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spelling	oai:doaj.org-article:546aba3faf4541ae8b7f35296aa741452021-11-04T04:43:22ZDextrin and polyurethane graft copolymers as drug carrier: Synthesis, characterization, drug release, biocompatibility and in-vitro toxicity2666-893910.1016/j.carpta.2021.100171https://doaj.org/article/546aba3faf4541ae8b7f35296aa741452021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666893921001390https://doaj.org/toc/2666-8939Chemical modification of dextrin with polyurethane as a graft has been synthesized for controlled drug release for longer time period by maintaining the hydrophobic–hydrophilic balance. Estimation of the degree of grafting is visualized from the integrated peak area in the NMR spectra. Particle nature of dextrin is converted into strip like morphology in polyurethane graft dextrin copolymers as obvious from atomic force microscopy. Drug release study of graft copolymers through in vitro studies indicates sustained drug release behavior as compared to pristine dextrin and specific interactions between polymer and drug have been verified through spectroscopic techniques. Biocompatibility of the graft copolymers has been revealed using cellular studies on cancerous HeLa cells through MTT assay and cell adhesion. Further, the cytotoxicity or the cell killing efficiency has been demonstrated resulting in significant cell mortality using the developed graft copolymers.Aparna ShuklaSwapan MaityBiswajit RayPralay MaitiElsevierarticleDextrinHydrophilic–hydrophobic balanceThermal stabilityMorphologyDrug deliveryCellular studiesBiochemistryQD415-436ENCarbohydrate Polymer Technologies and Applications, Vol 2, Iss , Pp 100171- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dextrin Hydrophilic–hydrophobic balance Thermal stability Morphology Drug delivery Cellular studies Biochemistry QD415-436
spellingShingle	Dextrin Hydrophilic–hydrophobic balance Thermal stability Morphology Drug delivery Cellular studies Biochemistry QD415-436 Aparna Shukla Swapan Maity Biswajit Ray Pralay Maiti Dextrin and polyurethane graft copolymers as drug carrier: Synthesis, characterization, drug release, biocompatibility and in-vitro toxicity
description	Chemical modification of dextrin with polyurethane as a graft has been synthesized for controlled drug release for longer time period by maintaining the hydrophobic–hydrophilic balance. Estimation of the degree of grafting is visualized from the integrated peak area in the NMR spectra. Particle nature of dextrin is converted into strip like morphology in polyurethane graft dextrin copolymers as obvious from atomic force microscopy. Drug release study of graft copolymers through in vitro studies indicates sustained drug release behavior as compared to pristine dextrin and specific interactions between polymer and drug have been verified through spectroscopic techniques. Biocompatibility of the graft copolymers has been revealed using cellular studies on cancerous HeLa cells through MTT assay and cell adhesion. Further, the cytotoxicity or the cell killing efficiency has been demonstrated resulting in significant cell mortality using the developed graft copolymers.
format	article
author	Aparna Shukla Swapan Maity Biswajit Ray Pralay Maiti
author_facet	Aparna Shukla Swapan Maity Biswajit Ray Pralay Maiti
author_sort	Aparna Shukla
title	Dextrin and polyurethane graft copolymers as drug carrier: Synthesis, characterization, drug release, biocompatibility and in-vitro toxicity
title_short	Dextrin and polyurethane graft copolymers as drug carrier: Synthesis, characterization, drug release, biocompatibility and in-vitro toxicity
title_full	Dextrin and polyurethane graft copolymers as drug carrier: Synthesis, characterization, drug release, biocompatibility and in-vitro toxicity
title_fullStr	Dextrin and polyurethane graft copolymers as drug carrier: Synthesis, characterization, drug release, biocompatibility and in-vitro toxicity
title_full_unstemmed	Dextrin and polyurethane graft copolymers as drug carrier: Synthesis, characterization, drug release, biocompatibility and in-vitro toxicity
title_sort	dextrin and polyurethane graft copolymers as drug carrier: synthesis, characterization, drug release, biocompatibility and in-vitro toxicity
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/546aba3faf4541ae8b7f35296aa74145
work_keys_str_mv	AT aparnashukla dextrinandpolyurethanegraftcopolymersasdrugcarriersynthesischaracterizationdrugreleasebiocompatibilityandinvitrotoxicity AT swapanmaity dextrinandpolyurethanegraftcopolymersasdrugcarriersynthesischaracterizationdrugreleasebiocompatibilityandinvitrotoxicity AT biswajitray dextrinandpolyurethanegraftcopolymersasdrugcarriersynthesischaracterizationdrugreleasebiocompatibilityandinvitrotoxicity AT pralaymaiti dextrinandpolyurethanegraftcopolymersasdrugcarriersynthesischaracterizationdrugreleasebiocompatibilityandinvitrotoxicity
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Dextrin and polyurethane graft copolymers as drug carrier: Synthesis, characterization, drug release, biocompatibility and in-vitro toxicity

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