The New Kid on the Block: HLA-C, a Key Regulator of Natural Killer Cells in Viral Immunity

The human leukocyte antigen system (HLA) is a cluster of highly polymorphic genes essential for the proper function of the immune system, and it has been associated with a wide range of diseases. HLA class I molecules present intracellular host- and pathogen-derived peptides to effector cells of the...

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Autores principales:	Sarah Vollmers, Annabelle Lobermeyer, Christian Körner
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	HLA-C NK cells killercell immunoglobulin-like receptors viral infection Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/546b7a8ed9404b83b0eca20b8c6d2c85
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spelling	oai:doaj.org-article:546b7a8ed9404b83b0eca20b8c6d2c852021-11-25T17:11:35ZThe New Kid on the Block: HLA-C, a Key Regulator of Natural Killer Cells in Viral Immunity10.3390/cells101131082073-4409https://doaj.org/article/546b7a8ed9404b83b0eca20b8c6d2c852021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3108https://doaj.org/toc/2073-4409The human leukocyte antigen system (HLA) is a cluster of highly polymorphic genes essential for the proper function of the immune system, and it has been associated with a wide range of diseases. HLA class I molecules present intracellular host- and pathogen-derived peptides to effector cells of the immune system, inducing immune tolerance in healthy conditions or triggering effective immune responses in pathological situations. HLA-C is the most recently evolved HLA class I molecule, only present in humans and great apes. Differentiating from its older siblings, HLA-A and HLA-B, HLA-C exhibits distinctive features in its expression and interaction partners. HLA-C serves as a natural ligand for multiple members of the killer-cell immunoglobulin-like receptor (KIR) family, which are predominately expressed by natural killer (NK) cells. NK cells are crucial for the early control of viral infections and accumulating evidence indicates that interactions between HLA-C and its respective KIR receptors determine the outcome and progression of viral infections. In this review, we focus on the unique role of HLA-C in regulating NK cell functions and its consequences in the setting of viral infections.Sarah VollmersAnnabelle LobermeyerChristian KörnerMDPI AGarticleHLA-CNK cellskillercell immunoglobulin-like receptorsviral infectionBiology (General)QH301-705.5ENCells, Vol 10, Iss 3108, p 3108 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HLA-C NK cells killercell immunoglobulin-like receptors viral infection Biology (General) QH301-705.5
spellingShingle	HLA-C NK cells killercell immunoglobulin-like receptors viral infection Biology (General) QH301-705.5 Sarah Vollmers Annabelle Lobermeyer Christian Körner The New Kid on the Block: HLA-C, a Key Regulator of Natural Killer Cells in Viral Immunity
description	The human leukocyte antigen system (HLA) is a cluster of highly polymorphic genes essential for the proper function of the immune system, and it has been associated with a wide range of diseases. HLA class I molecules present intracellular host- and pathogen-derived peptides to effector cells of the immune system, inducing immune tolerance in healthy conditions or triggering effective immune responses in pathological situations. HLA-C is the most recently evolved HLA class I molecule, only present in humans and great apes. Differentiating from its older siblings, HLA-A and HLA-B, HLA-C exhibits distinctive features in its expression and interaction partners. HLA-C serves as a natural ligand for multiple members of the killer-cell immunoglobulin-like receptor (KIR) family, which are predominately expressed by natural killer (NK) cells. NK cells are crucial for the early control of viral infections and accumulating evidence indicates that interactions between HLA-C and its respective KIR receptors determine the outcome and progression of viral infections. In this review, we focus on the unique role of HLA-C in regulating NK cell functions and its consequences in the setting of viral infections.
format	article
author	Sarah Vollmers Annabelle Lobermeyer Christian Körner
author_facet	Sarah Vollmers Annabelle Lobermeyer Christian Körner
author_sort	Sarah Vollmers
title	The New Kid on the Block: HLA-C, a Key Regulator of Natural Killer Cells in Viral Immunity
title_short	The New Kid on the Block: HLA-C, a Key Regulator of Natural Killer Cells in Viral Immunity
title_full	The New Kid on the Block: HLA-C, a Key Regulator of Natural Killer Cells in Viral Immunity
title_fullStr	The New Kid on the Block: HLA-C, a Key Regulator of Natural Killer Cells in Viral Immunity
title_full_unstemmed	The New Kid on the Block: HLA-C, a Key Regulator of Natural Killer Cells in Viral Immunity
title_sort	new kid on the block: hla-c, a key regulator of natural killer cells in viral immunity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/546b7a8ed9404b83b0eca20b8c6d2c85
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The New Kid on the Block: HLA-C, a Key Regulator of Natural Killer Cells in Viral Immunity

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