Lipoprotein concentration in patients requiring extracorporeal membrane oxygenation

Abstract Extracorporeal membrane oxygenation (ECMO), a relevant technology for patients with acute respiratory distress syndrome (ARDS) or acute cardiac failure (ACF), is a frequent cause of systemic inflammatory response syndrome. During sepsis, HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) c...

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Autores principales:	Sébastien Tanaka, Christian De Tymowski, Nathalie Zappella, Aurélie Snauwaert, Tiphaine Robert, Brice Lortat-Jacob, Yves Castier, Alexy Tran-Dinh, Parvine Tashk, Donia Bouzid, Marylou Para, Quentin Pellenc, Enora Atchade, Olivier Meilhac, Philippe Montravers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/546b8601a90e48cd9aeb5db7db061c14
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spelling	oai:doaj.org-article:546b8601a90e48cd9aeb5db7db061c142021-12-02T16:35:11ZLipoprotein concentration in patients requiring extracorporeal membrane oxygenation10.1038/s41598-021-96728-32045-2322https://doaj.org/article/546b8601a90e48cd9aeb5db7db061c142021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96728-3https://doaj.org/toc/2045-2322Abstract Extracorporeal membrane oxygenation (ECMO), a relevant technology for patients with acute respiratory distress syndrome (ARDS) or acute cardiac failure (ACF), is a frequent cause of systemic inflammatory response syndrome. During sepsis, HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) concentrations decrease, and an association between low lipoprotein levels and poor outcomes was reported. There are no data from patients undergoing ECMO. The goal of this study was to characterize the lipoprotein profiles of ICU patients requiring ECMO. All consecutive patients admitted for ARDS or ACF requiring ECMO were prospectively included. Daily lipoprotein levels and short-term prognosis outcome were assessed. 25 patients were included. On admission, lipoprotein concentrations were low, under the reference values ([HDL-C] = 0.6[0.4–0.8]mmol/L;[LDL-C] = 1.3[1.0–1.7]mmol/L). A statistically significant rise in lipoproteins overtime was observed during the ICU stay. We found no relationship between lipoproteins concentrations and mortality on Day-28 (p = 0.689 and p = 0.979, respectively). Comparison of surviving patients with non-surviving patients did not reveal any differences in lipoproteins concentrations. Stratification between septic and non-septic patients demonstrated that septic patients had lower lipoproteins concentrations on admission (HDL-C: 0.5[0.3–0.6]mmol/l vs 0.8[0.6–0.9]mmol/l, p = 0.003; LDL-C: 1.1[0.9–1.5]mmol/l vs 1.5[1.3–2.6]mmol/l; p = 0.012), whereas these two groups were comparable in terms of severity and outcomes. HDL-C concentrations during ICU hospitalization were also significantly lower in the septic group than in the non-septic group (p = 0.035). In conclusion, Lipoprotein concentrations are low in patients requiring ECMO but are not associated with poor outcomes. The subpopulation of septic patients had lower lipoprotein levels overtime, which reinforces the potential key-role of these particles during sepsis.Sébastien TanakaChristian De TymowskiNathalie ZappellaAurélie SnauwaertTiphaine RobertBrice Lortat-JacobYves CastierAlexy Tran-DinhParvine TashkDonia BouzidMarylou ParaQuentin PellencEnora AtchadeOlivier MeilhacPhilippe MontraversNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sébastien Tanaka Christian De Tymowski Nathalie Zappella Aurélie Snauwaert Tiphaine Robert Brice Lortat-Jacob Yves Castier Alexy Tran-Dinh Parvine Tashk Donia Bouzid Marylou Para Quentin Pellenc Enora Atchade Olivier Meilhac Philippe Montravers Lipoprotein concentration in patients requiring extracorporeal membrane oxygenation
description	Abstract Extracorporeal membrane oxygenation (ECMO), a relevant technology for patients with acute respiratory distress syndrome (ARDS) or acute cardiac failure (ACF), is a frequent cause of systemic inflammatory response syndrome. During sepsis, HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) concentrations decrease, and an association between low lipoprotein levels and poor outcomes was reported. There are no data from patients undergoing ECMO. The goal of this study was to characterize the lipoprotein profiles of ICU patients requiring ECMO. All consecutive patients admitted for ARDS or ACF requiring ECMO were prospectively included. Daily lipoprotein levels and short-term prognosis outcome were assessed. 25 patients were included. On admission, lipoprotein concentrations were low, under the reference values ([HDL-C] = 0.6[0.4–0.8]mmol/L;[LDL-C] = 1.3[1.0–1.7]mmol/L). A statistically significant rise in lipoproteins overtime was observed during the ICU stay. We found no relationship between lipoproteins concentrations and mortality on Day-28 (p = 0.689 and p = 0.979, respectively). Comparison of surviving patients with non-surviving patients did not reveal any differences in lipoproteins concentrations. Stratification between septic and non-septic patients demonstrated that septic patients had lower lipoproteins concentrations on admission (HDL-C: 0.5[0.3–0.6]mmol/l vs 0.8[0.6–0.9]mmol/l, p = 0.003; LDL-C: 1.1[0.9–1.5]mmol/l vs 1.5[1.3–2.6]mmol/l; p = 0.012), whereas these two groups were comparable in terms of severity and outcomes. HDL-C concentrations during ICU hospitalization were also significantly lower in the septic group than in the non-septic group (p = 0.035). In conclusion, Lipoprotein concentrations are low in patients requiring ECMO but are not associated with poor outcomes. The subpopulation of septic patients had lower lipoprotein levels overtime, which reinforces the potential key-role of these particles during sepsis.
format	article
author	Sébastien Tanaka Christian De Tymowski Nathalie Zappella Aurélie Snauwaert Tiphaine Robert Brice Lortat-Jacob Yves Castier Alexy Tran-Dinh Parvine Tashk Donia Bouzid Marylou Para Quentin Pellenc Enora Atchade Olivier Meilhac Philippe Montravers
author_facet	Sébastien Tanaka Christian De Tymowski Nathalie Zappella Aurélie Snauwaert Tiphaine Robert Brice Lortat-Jacob Yves Castier Alexy Tran-Dinh Parvine Tashk Donia Bouzid Marylou Para Quentin Pellenc Enora Atchade Olivier Meilhac Philippe Montravers
author_sort	Sébastien Tanaka
title	Lipoprotein concentration in patients requiring extracorporeal membrane oxygenation
title_short	Lipoprotein concentration in patients requiring extracorporeal membrane oxygenation
title_full	Lipoprotein concentration in patients requiring extracorporeal membrane oxygenation
title_fullStr	Lipoprotein concentration in patients requiring extracorporeal membrane oxygenation
title_full_unstemmed	Lipoprotein concentration in patients requiring extracorporeal membrane oxygenation
title_sort	lipoprotein concentration in patients requiring extracorporeal membrane oxygenation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/546b8601a90e48cd9aeb5db7db061c14
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Lipoprotein concentration in patients requiring extracorporeal membrane oxygenation

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